Detailed information for compound 216764

Basic information

Technical information
  • TDR Targets ID: 216764
  • Name: 4-(3,5-dichlorophenyl)benzaldehyde
  • MW: 251.108 | Formula: C13H8Cl2O
  • H donors: 0 H acceptors: 1 LogP: 4.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(cc1)c1cc(Cl)cc(c1)Cl
  • InChi: 1S/C13H8Cl2O/c14-12-5-11(6-13(15)7-12)10-3-1-9(8-16)2-4-10/h1-8H
  • InChiKey: YEFGGURFOJFIMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 221018-04-8
  • 4PNL-Q03-0
  • ZINC02386697

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.127 0.1316
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.127 0.127
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0024 0.0396 0.0396
Echinococcus granulosus glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Echinococcus multilocularis GPCR, family 2 0.0015 0.0074 0.0074
Brugia malayi Cation transporter family protein 0.0118 0.3672 0.4763
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.127 1
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0074
Brugia malayi MAP kinase sur-1 0.0049 0.127 0.1647
Echinococcus granulosus GPCR family 2 0.0015 0.0074 0.0074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0259 0.0099
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0074
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0024 0.0396 0.0396
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0518 0.0518
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0024 0.0396 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.127 0.127
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Echinococcus granulosus protein phosphatase 1b 0.0147 0.4724 0.4724
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0024 0.0396 0.0396
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0259 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0074 0.0074
Trichomonas vaginalis protein phosphatase type 2C, putative 0.0022 0.0305 0.117
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0396 0.0514
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.127 0.1316
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Plasmodium vivax protein phosphatase PPM2, putative 0.0022 0.0305 0.3751
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0024 0.0396 0.0396
Brugia malayi Cation transporter family protein 0.0024 0.0396 0.0514
Brugia malayi Protein phosphatase 2C containing protein 0.0169 0.5476 0.7103
Schistosoma mansoni ap endonuclease 0.0018 0.0177 0.0177
Onchocerca volvulus 0.0024 0.0396 0.1703
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.127 0.1316
Toxoplasma gondii protein phosphatase 2C domain-containing protein 0.0022 0.0305 0.117
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0332 0.1423
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0259 0.0259
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0305 0.0154
Echinococcus granulosus glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0074 0.0096
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0259 0.2408
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0259 0.0751
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Entamoeba histolytica hypothetical protein 0.0023 0.0332 1
Echinococcus multilocularis glycine receptor subunit beta 0.0118 0.3672 0.3672
Echinococcus granulosus geminin 0.0164 0.5297 0.5297
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Onchocerca volvulus Putative nachr subunit 0.0024 0.0396 0.1703
Schistosoma mansoni survival motor neuron protein 0.0047 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Loa Loa (eye worm) hypothetical protein 0.0022 0.0305 0.0305
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0396 0.0514
Schistosoma mansoni importin beta-1 0.0028 0.0518 0.0518
Loa Loa (eye worm) GABA receptor subunit 0.0106 0.3276 0.3276
Trypanosoma cruzi protein phosphatase 2C-like, putative 0.0022 0.0305 0.0154
Brugia malayi Cation transporter family protein 0.0024 0.0396 0.0514
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0118 0.3672 0.3672
Mycobacterium ulcerans phytoene synthase, CrtB 0.0079 0.2324 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0518 0.0411
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0024 0.0396 0.0514
Schistosoma mansoni hypothetical protein 0.0079 0.2324 0.2324
Schistosoma mansoni hypothetical protein 0.0047 0.1204 0.1204
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.7709 0.7709
Schistosoma mansoni hypothetical protein 0.0164 0.5297 0.5297
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.127 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Schistosoma mansoni protein phosphatase 2C 0.0147 0.4724 0.4724
Leishmania major hypothetical protein, conserved 0.0079 0.2324 0.2587
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0024 0.0396 0.0396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0177 0.0177
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0024 0.0396 0.0396
Schistosoma mansoni protein phosphatase 2c gamma 0.0022 0.0305 0.0305
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0104 0.321 0.4164
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 1 1
Schistosoma mansoni ran 0.0021 0.0259 0.0259
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0024 0.0396 0.0514
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Trypanosoma brucei protein kinase, putative 0.0049 0.127 0.1316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Onchocerca volvulus 0.0024 0.0396 0.1703
Brugia malayi hypothetical protein 0.0232 0.7709 1
Toxoplasma gondii protein phosphatase 2C domain-containing protein 0.0022 0.0305 0.117
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0305 0.0305
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0104 0.321 0.321
Leishmania major squalene synthase, putative 0.0254 0.8477 1
Trichomonas vaginalis ran, putative 0.0021 0.0259 0.0751
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0259 0.0099
Trypanosoma cruzi squalene synthase, putative 0.0254 0.8477 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0259 0.0259
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0332 0.1423
Echinococcus granulosus glycine receptor subunit beta 0.0118 0.3672 0.3672
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0232 0.7709 0.7709
Onchocerca volvulus 0.0047 0.1204 0.5182
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0259 0.2408
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Echinococcus granulosus glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0118 0.3672 0.3672
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0074
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0396 0.0396
Echinococcus multilocularis Squalene phytoene synthase 0.0079 0.2324 0.2324
Plasmodium vivax importin-beta 2, putative 0.0028 0.0518 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0259 0.0099
Schistosoma mansoni hypothetical protein 0.0164 0.5297 0.5297
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.127 1
Trypanosoma cruzi protein phosphatase 2C, putative 0.0022 0.0305 0.0154
Echinococcus multilocularis protein phosphatase 1b 0.0147 0.4724 0.4724
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0074
Entamoeba histolytica protein phosphatase, putative 0.0022 0.0305 0.9168
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0305 0.0305
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0024 0.0396 0.0396
Echinococcus granulosus glycine receptor subunit beta 0.0118 0.3672 0.3672
Brugia malayi probable protein phosphatase 2C 0.0022 0.0305 0.0395
Echinococcus granulosus nAChR subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0177 0.5
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0305 0.0305
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0118 0.3672 0.3672
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0104 0.321 0.321
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0074
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.127 1
Onchocerca volvulus 0.0024 0.0396 0.1703
Loa Loa (eye worm) protein phosphatase 2C containing protein 0.0169 0.5476 0.5476
Echinococcus multilocularis snurportin 1 0.0297 1 1
Echinococcus granulosus protein phosphatase 2c 0.0022 0.0305 0.0305
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0118 0.3672 0.3672
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0118 0.3672 0.3672
Plasmodium falciparum importin beta, putative 0.0028 0.0518 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0177 0.0177
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0024 0.0396 0.0514
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0396 0.0514
Schistosoma mansoni ran 0.0021 0.0259 0.0259
Leishmania major protein phosphatase 2C, putative 0.0022 0.0305 0.0154
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0696 0.0903
Trypanosoma cruzi squalene synthase, putative 0.0254 0.8477 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0259 0.0751
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.127 0.127
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0022 0.0305 0.0305
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0024 0.0396 0.0396
Brugia malayi Importin beta-1 subunit 0.0028 0.0518 0.0672
Echinococcus granulosus importin subunit beta 1 0.0028 0.0518 0.0518
Brugia malayi Protein phosphatase 2C containing protein 0.0022 0.0305 0.0395
Onchocerca volvulus Putative protein phosphatase 2C 0.0022 0.0305 0.1311
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0396 0.0396
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0396 0.0514
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.127 0.1316
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0024 0.0396 0.0514
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Echinococcus multilocularis glycine receptor subunit beta 0.0118 0.3672 0.3672
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Schistosoma mansoni hypothetical protein 0.0033 0.0696 0.0696
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0033 0.0696 0.0696
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.7709 0.7709
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0118 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0106 0.3276 0.3276
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0079 0.2324 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.127 0.127
Leishmania major GTP-binding protein, putative 0.0021 0.0259 0.0099
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.127 0.127
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0518 0.3119
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0177 0.0177
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0518 0.0411
Onchocerca volvulus 0.0024 0.0396 0.1703
Plasmodium falciparum protein phosphatase PPM2 0.0022 0.0305 0.3751
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1232 0.1598
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0106 0.3276 0.425
Trypanosoma brucei squalene synthase, putative 0.0254 0.8477 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1232 0.1232
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0177 0.0229
Brugia malayi excitatory GABA receptor EXP-1A 0.0024 0.0396 0.0514
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1204 0.1562
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0332 0.1423
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0074
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0396 0.0396
Schistosoma mansoni ap endonuclease 0.0018 0.0177 0.0177
Echinococcus granulosus protein phosphatase 1b 0.0169 0.5476 0.5476
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0396 0.0396
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0396 0.0396
Echinococcus granulosus Squalene phytoene synthase 0.0079 0.2324 0.2324
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.127 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.127 0.1316
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.127 1
Onchocerca volvulus 0.0024 0.0396 0.1703
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0118 0.3672 0.3672
Echinococcus multilocularis protein phosphatase 1b 0.0169 0.5476 0.5476
Loa Loa (eye worm) hypothetical protein 0.0079 0.2324 0.2324
Brugia malayi RNA, U transporter 1 0.0079 0.2325 0.3016
Schistosoma mansoni protein phosphatase 2C 0.0147 0.4724 0.4724
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0024 0.0396 0.0396
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1232 0.1598
Schistosoma mansoni hypothetical protein 0.0297 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.127 0.1316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0518 0.0518
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0118 0.3672 0.3672
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.127 0.1316
Echinococcus multilocularis nAChR subunit 0.0024 0.0396 0.0396
Entamoeba histolytica Ran family GTPase 0.0021 0.0259 0.7792
Giardia lamblia Phosphatase 0.0022 0.0305 0.117
Leishmania major protein phosphatase 2C-like protein 0.0022 0.0305 0.0154
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Onchocerca volvulus 0.0024 0.0396 0.1703
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0074 0.0096
Trypanosoma brucei protein phosphatase 2C, putative 0.0022 0.0305 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0396 0.0514
Loa Loa (eye worm) LGC-31 protein 0.0024 0.0396 0.0396
Echinococcus multilocularis protein phosphatase 2C 0.0022 0.0305 0.0305
Schistosoma mansoni nAChR subunit 0.0024 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0048 0.1232 0.1232
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0074
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0024 0.0396 0.0514
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.127 0.127
Trypanosoma cruzi phytoene synthase, putative 0.0079 0.2324 0.2587
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0079 0.2324 1
Giardia lamblia Ser/Thr phosphatase 2C, putative 0.0022 0.0305 0.117
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0024 0.0396 0.0514
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0396 0.0396
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0332 0.0187
Echinococcus multilocularis geminin 0.0164 0.5297 0.5297
Leishmania major importin beta-1 subunit, putative 0.0023 0.0332 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0177 0.5322
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0177 0.5
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0104 0.321 0.321
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0396 0.0396
Schistosoma mansoni protein phosphatase 2C 0.0169 0.5476 0.5476
Loa Loa (eye worm) hypothetical protein 0.0024 0.0396 0.0396

Activities

Activity type Activity value Assay description Source Reference
Fibril formation (functional) = 25.4 % Transthyretin (TTR) amyloidogenesis inhibition activity of the compound by employing an acid-mediated (pH 4.4) WTTTR amyloid fibril formation assay, at 7.2 microM conc. ChEMBL. 14711308
Fibril formation (functional) = 25.4 % Transthyretin (TTR) amyloidogenesis inhibition activity of the compound by employing an acid-mediated (pH 4.4) WTTTR amyloid fibril formation assay, at 7.2 microM conc. ChEMBL. 14711308

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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