TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 528.66 | Formula: C28H36N2O6S
H donors: 3 H acceptors: 4 LogP: 4.78 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(OC)cc(c1)c1ccc(cc1)CC(C(=O)O)NC(=O)C1(CCCC1)NC(=O)[C@H](C(C)C)S
InChi: 1S/C28H36N2O6S/c1-17(2)24(37)25(31)30-28(11-5-6-12-28)27(34)29-23(26(32)33)13-18-7-9-19(10-8-18)20-14-21(35-3)16-22(15-20)36-4/h7-10,14-17,23-24,37H,5-6,11-13H2,1-4H3,(H,29,34)(H,30,31)(H,32,33)/t23?,24-/m0/s1
InChiKey: SOPZWLYKKXQFNX-CGAIIQECSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	endothelin converting enzyme 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus granulosus	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Neospora caninum	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium leprae	probable zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Onchocerca volvulus		Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium ulcerans	zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	IPR000718,Peptidase M13, neprilysin,domain-containing	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Toxoplasma gondii	peptidase family M13 protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus multilocularis	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.2408	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0141	0.4714	0.3623
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Onchocerca volvulus		0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0141	0.4714	0.4303
Mycobacterium leprae	probable zinc metalloprotease	0.0114	0.3323	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.2408	0.0842
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0141	0.4714	0.3623
Onchocerca volvulus		0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0063	0.072	0.0343
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Brugia malayi	GnHR receptor homolog	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0141	0.4714	0.4303
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	sex peptide receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	tm gpcr rhodopsin	0.0141	0.4714	0.3623
Brugia malayi	RE15519p	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	serotonin receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	g protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	neuropeptide receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	endothelin converting enzyme 1	0.0114	0.3323	0.1945
Echinococcus granulosus	neuropeptide receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0141	0.4714	0.4499
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0141	0.4714	0.3623
Echinococcus multilocularis	g-protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	allatostatin A receptor	0.0141	0.4714	0.3623
Onchocerca volvulus		0.0141	0.4714	0.4499
Brugia malayi	Melatonin receptor type 1A	0.0141	0.4714	0.4303
Echinococcus multilocularis	serotonin receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1806	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	neuropeptide F-like receptor	0.0141	0.4714	0.4714
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	neuropeptides capa receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0141	0.4714	0.3623
Echinococcus granulosus	neuropeptide FF receptor 2	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	orexin receptor type 2	0.0141	0.4714	0.3623
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0141	0.4714	0.4714
Brugia malayi	neuropeptide F receptor	0.0141	0.4714	0.4303
Brugia malayi	putative neuropeptide receptor	0.0141	0.4714	0.4303
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	endothelin converting enzyme 1	0.0114	0.3323	0.1945
Echinococcus multilocularis	neuropeptide receptor A26	0.0141	0.4714	0.3623
Brugia malayi	prolyl oligopeptidase family protein	0.0082	0.171	0.1067
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0141	0.4714	0.4714
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0141	0.4714	0.3623
Echinococcus multilocularis	sex peptide receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0058	0.0444	0.0444
Onchocerca volvulus		0.0141	0.4714	0.4499
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Loa Loa (eye worm)	prolyl oligopeptidase	0.0245	1	1
Schistosoma mansoni	adenoreceptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3323	0.3051
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0245	1	1
Brugia malayi	larval opioid receptor	0.0141	0.4714	0.4303
Giardia lamblia	Kinase, PLK	0.0096	0.2408	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1806	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Schistosoma mansoni	hypothetical protein	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Onchocerca volvulus		0.0141	0.4714	0.4499
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	neuropeptide receptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0245	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	neuropeptide f receptor 76f	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	G-protein coupled receptor	0.0141	0.4714	0.4499
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0245	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	hypothetical protein	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Schistosoma mansoni	amine GPCR	0.0141	0.4714	0.4714
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0141	0.4714	0.3623
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0114	0.3323	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	neuropeptide receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	histamine h1 receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	biogenic amine 5HT receptor	0.0141	0.4714	0.3623
Brugia malayi	G protein-coupled receptor F59B2.13	0.0141	0.4714	0.4303
Brugia malayi	G protein-coupled receptor	0.0141	0.4714	0.4303
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0114	0.3323	0.2804
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	fmrfamide receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	biogenic amine receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	7TM GPCR rhodopsin	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1806	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.2408	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0141	0.4714	0.4499
Echinococcus granulosus	orexin receptor type 2	0.0141	0.4714	0.3623
Echinococcus granulosus	neuropeptide Y receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	dro:myosuppressin receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	somatostatin receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	opsin-like receptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	neuropeptide receptor A26	0.0141	0.4714	0.3623
Schistosoma mansoni	biogenic amine receptor	0.0141	0.4714	0.4714
Toxoplasma gondii	peptidase family M13 protein	0.0114	0.3323	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.2408	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1806	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	G protein coupled receptor 139	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	amine GPCR	0.0141	0.4714	0.4714
Echinococcus granulosus	neuropeptides capa receptor	0.0141	0.4714	0.3623
Brugia malayi	Serotonin receptor	0.0141	0.4714	0.4303
Loa Loa (eye worm)	TYRA-2 protein	0.0141	0.4714	0.4499
Onchocerca volvulus		0.0141	0.4714	0.4499
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Echinococcus granulosus	g-protein coupled receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	opsin-like receptor	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Schistosoma mansoni	amine GPCR	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Echinococcus multilocularis	serotonin receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	g protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0141	0.4714	0.3623
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0141	0.4714	0.4714
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0058	0.0444	0.0444
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0114	0.3323	0.3323
Schistosoma mansoni	myosin xvIII	0.0141	0.4714	0.4714
Echinococcus multilocularis	neuropeptides capa receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	neuropeptide receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0141	0.4714	0.3623
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0141	0.4714	0.4714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Brugia malayi	G-protein coupled receptor	0.0141	0.4714	0.4303
Echinococcus multilocularis	neuropeptide receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	amine GPCR	0.0141	0.4714	0.4714
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	somatostatin receptor	0.0141	0.4714	0.3623
Onchocerca volvulus		0.0141	0.4714	0.4499
Brugia malayi	Peptidase family M13 containing protein	0.0114	0.3323	0.2804
Onchocerca volvulus		0.0141	0.4714	0.4499
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0141	0.4714	0.4714
Echinococcus granulosus	g protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	growth hormone secretagogue receptor	0.0141	0.4714	0.4714
Brugia malayi	AKH receptor	0.0141	0.4714	0.4303
Echinococcus granulosus	hypothetical protein	0.0141	0.4714	0.3623
Brugia malayi	Dopamine receptor protein 2	0.0141	0.4714	0.4303
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0141	0.4714	0.3623
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.2408	1
Brugia malayi	G-protein coupled receptor	0.0141	0.4714	0.4303
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0082	0.171	0.171
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0141	0.4714	0.4499
Echinococcus multilocularis	neuropeptide s receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	hypothetical protein	0.0141	0.4714	0.4714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0141	0.4714	0.3623
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3323	0.3051
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Echinococcus granulosus	tm gpcr rhodopsin	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0141	0.4714	0.3623
Echinococcus multilocularis	neuropeptide Y receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	neuropeptide receptor	0.0141	0.4714	0.4714
Schistosoma mansoni	biogenic amine receptor	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0141	0.4714	0.3623
Brugia malayi	ORL1-like opioid receptor	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Schistosoma mansoni	neuropeptide receptor	0.0141	0.4714	0.4714
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Brugia malayi	follicle stimulating hormone receptor	0.0141	0.4714	0.4303
Brugia malayi	neuropeptide F receptor	0.0141	0.4714	0.4303
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.1806	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	fmrfamide receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Onchocerca volvulus		0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0058	0.0444	0.0444
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0141	0.4714	0.4499
Brugia malayi	sulfakinin receptor protein	0.0141	0.4714	0.4303
Brugia malayi	putative neuropeptide receptor NPR1	0.0141	0.4714	0.4303
Loa Loa (eye worm)	G-protein coupled receptor	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	opsin-like receptor	0.0141	0.4714	0.4714
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0444	0.0444
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0141	0.4714	0.4714
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.2408	0.2408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Loa Loa (eye worm)	neuropeptide F receptor	0.0141	0.4714	0.4499
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.2408	0.1819
Trypanosoma brucei	polo-like protein kinase	0.0096	0.2408	1
Echinococcus granulosus	neuropeptide s receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.2408	0.0842
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0141	0.4714	0.4303
Loa Loa (eye worm)	melatonin receptor type 1A	0.0141	0.4714	0.4499
Onchocerca volvulus		0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus multilocularis	neuropeptides capa receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	neuropeptide F-like receptor	0.0141	0.4714	0.4714
Onchocerca volvulus		0.0141	0.4714	0.4499
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Mycobacterium ulcerans	zinc metalloprotease	0.0114	0.3323	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Brugia malayi	Dopamine receptor	0.0141	0.4714	0.4303
Echinococcus multilocularis	g protein coupled receptor	0.0141	0.4714	0.3623
Echinococcus granulosus	biogenic amine 5HT receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0141	0.4714	0.4714
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0141	0.4714	0.3623
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0141	0.4714	0.3623
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Onchocerca volvulus		0.0141	0.4714	0.4499
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Echinococcus granulosus	g protein coupled receptor	0.0141	0.4714	0.3623
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0141	0.4714	0.3623
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0141	0.4714	0.3623
Schistosoma mansoni	amine GPCR	0.0141	0.4714	0.4714
Brugia malayi	hypothetical protein	0.0141	0.4714	0.4303
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.2408	0.2099
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0141	0.4714	0.4714
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0141	0.4714	0.3623
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.2408	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0141	0.4714	0.4499
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0141	0.4714	0.4714
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0245	1	1
Brugia malayi	Serotonin receptor	0.0141	0.4714	0.4303
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3323	0.3051
Echinococcus granulosus	7tm_1 domain containing protein	0.0141	0.4714	0.3623
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0141	0.4714	0.4499
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0141	0.4714	0.3623
Echinococcus granulosus	fmrfamide receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	allatostatin A receptor	0.0141	0.4714	0.3623
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0141	0.4714	0.3623
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1907	0.1578
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0141	0.4714	0.4303
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.1806	0.1473
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0141	0.4714	0.3623
Echinococcus granulosus	tm gpcr rhodopsin	0.0141	0.4714	0.3623
Echinococcus multilocularis	neuropeptide Y receptor	0.0141	0.4714	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0141	0.4714	0.4499
Echinococcus granulosus	dro:myosuppressin receptor	0.0141	0.4714	0.3623
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0141	0.4714	0.4714
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0141	0.4714	0.4499
Echinococcus multilocularis	G protein coupled receptor 139	0.0141	0.4714	0.3623
Brugia malayi	Dopamine receptor protein 1	0.0141	0.4714	0.4303
Schistosoma mansoni	hypothetical protein	0.0141	0.4714	0.4714
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.2408	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0141	0.4714	0.4499

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 990 nM	In vitro inhibitory activity was tested against Endothelin converting enzyme 1	ChEMBL.	11212114
IC50 (binding)	= 990 nM	In vitro inhibitory activity was tested against Endothelin converting enzyme 1	ChEMBL.	11212114

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 218183