TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 483.512 | Formula: C29H25NO6
H donors: 0 H acceptors: 3 LogP: 5.87 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)/C(=C/c1cccc(c1)OCC(=O)OC)/c1nc(c(o1)c1ccccc1)c1ccccc1
InChi: 1S/C29H25NO6/c1-3-34-29(32)24(18-20-11-10-16-23(17-20)35-19-25(31)33-2)28-30-26(21-12-6-4-7-13-21)27(36-28)22-14-8-5-9-15-22/h4-18H,3,19H2,1-2H3/b24-18+
InChiKey: URSXUVSQVNESIX-HKOYGPOVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	animal heme peroxidase	0.1193	0.9943	0.9943
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.028	0.2145	0.2145
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0078	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0049	0.0181	0.0181
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0034	0.0048	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Schistosoma mansoni	shc transforming protein	0.0034	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase Srms	0.005	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.005	0.0184	0.0184
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0272	0.0273
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0045	0.014	0.014
Onchocerca volvulus		0.0034	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase Src64B	0.028	0.2145	0.2145
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0045	0.014	0.014
Schistosoma mansoni	peroxidasin	0.1195	0.9955	1
Schistosoma mansoni	peroxidasin	0.1188	0.9898	0.9943
Onchocerca volvulus		0.0034	0.0048	0.0048
Loa Loa (eye worm)	TK/INSR protein kinase	0.0203	0.149	0.149
Loa Loa (eye worm)	SH2 domain-containing protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0045	0.014	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Echinococcus granulosus	serine threonine protein kinase nrc	0.008	0.0443	0.0443
Echinococcus granulosus	peroxidasin	0.12	1	1
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Brugia malayi	Hr1 repeat family protein	0.0045	0.014	0.014
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0034	0.0048	0.0048
Entamoeba histolytica	protein kinase, putative	0.0122	0.0796	0.4933
Trichomonas vaginalis	STE family protein kinase	0.0934	0.7735	1
Echinococcus granulosus	N chimaerin	0.0049	0.0181	0.0181
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0034	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0115	0.0739	0.0956
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0062	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus granulosus	expressed conserved protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.028	0.2145	0.2145
Echinococcus granulosus	protein kinase c epsilon type	0.006	0.0272	0.0272
Onchocerca volvulus		0.005	0.0184	0.0185
Brugia malayi	Sex muscle abnormal protein 5	0.0062	0.0289	0.0289
Schistosoma mansoni	tyrosine kinase	0.0224	0.1673	0.168
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0272	0.0273
Echinococcus multilocularis	nervana 2	0.0073	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Brugia malayi	Protein kinase domain containing protein	0.0045	0.014	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0085	0.048	0.2976
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0115	0.0739	0.0956
Schistosoma mansoni	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0034	0.0048	0.0048
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0348	0.2728	0.2728
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0045	0.014	0.014
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0251	0.1904	0.1904
Echinococcus granulosus	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Echinococcus multilocularis	SHC transforming protein 3	0.0034	0.0048	0.0048
Onchocerca volvulus	Peroxidasin homolog	0.1193	0.9943	1
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0115	0.0739	0.0956
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0115	0.0739	0.0956
Echinococcus granulosus	tyrosine protein kinase HCK	0.0217	0.1614	0.1614
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0115	0.0739	0.0956
Loa Loa (eye worm)	animal heme peroxidase	0.1188	0.9898	0.9898
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0203	0.149	0.149
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0045	0.014	0.014
Entamoeba histolytica	protein kinase, putative	0.0041	0.0113	0.07
Schistosoma mansoni	tyrosine kinase	0.0317	0.2461	0.2472
Onchocerca volvulus		0.005	0.0184	0.0185
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0049	0.0181	0.0181
Onchocerca volvulus	Tyrosine kinase homolog	0.0326	0.254	0.2555
Brugia malayi	protein-tyrosine kinase	0.0251	0.1904	0.1904
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.028	0.2145	0.2145
Brugia malayi	Protein kinase domain containing protein	0.0045	0.014	0.014
Entamoeba histolytica	protein kinase, putative	0.0045	0.014	0.0865
Brugia malayi	Furin-like cysteine rich region family protein	0.0608	0.4948	0.4948
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0034	0.0048	0.0048
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.0739	0.0956
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0034	0.0048	0.0048
Schistosoma mansoni	serine/threonine-protein kinase	0.0085	0.048	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Brugia malayi	Protein kinase domain containing protein	0.0122	0.0796	0.0796
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0045	0.014	0.014
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0117	0.0759	0.0759
Echinococcus granulosus	signal transduction protein lnk realted	0.0034	0.0048	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.014	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Loa Loa (eye worm)	SH2 domain-containing protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0034	0.0048	0.0048
Entamoeba histolytica	SH2 domain containing protein	0.0034	0.0048	0.0298
Trichomonas vaginalis	STE family protein kinase	0.0934	0.7735	1
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Onchocerca volvulus		0.005	0.0184	0.0185
Echinococcus granulosus	tyrosine protein kinase Src42A	0.028	0.2145	0.2145
Brugia malayi	Protein kinase domain containing protein	0.0203	0.149	0.149
Loa Loa (eye worm)	animal heme peroxidase	0.1188	0.9898	0.9898
Echinococcus multilocularis	insulin receptor	0.0203	0.149	0.149
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0115	0.0739	0.0739
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Schistosoma mansoni	growth factor receptor-bound protein	0.0062	0.0289	0.0291
Onchocerca volvulus	Dual oxidase homolog	0.1188	0.9898	0.9955
Brugia malayi	hypothetical protein	0.0034	0.0048	0.0048
Brugia malayi	p70 ribosomal S6 kinase beta	0.0117	0.0759	0.0759
Schistosoma mansoni	serine/threonine kinase	0.0045	0.014	0.014
Giardia lamblia	Kinase, CMGC MAPK	0.0115	0.0739	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0049	0.0181	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	SH2 domain containing protein 7	0.0034	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.005	0.0184	0.0184
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0217	0.1614	0.1614
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0085	0.048	0.2976
Echinococcus granulosus	epidermal growth factor receptor	0.0332	0.2596	0.2596
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0033	0.0037	0.023
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Schistosoma mansoni	suppressor of cytokine signaling	0.0034	0.0048	0.0048
Echinococcus multilocularis	protein kinase c epsilon type	0.006	0.0272	0.0272
Echinococcus granulosus	tyrosine protein kinase Blk	0.0251	0.1904	0.1904
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0289	0.0289
Echinococcus granulosus	NCK adaptor protein	0.0062	0.0289	0.0289
Echinococcus granulosus	nervana 2	0.0073	0.0378	0.0378
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0034	0.0048	0.0048
Schistosoma mansoni	serine/threonine-protein kinase	0.0085	0.048	0.0483
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Brugia malayi	Raf kinase	0.0443	0.3538	0.3538
Brugia malayi	hypothetical protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	c src tyrosine kinase	0.0078	0.0425	0.0425
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0739	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.006	0.0272	0.0272
Echinococcus granulosus	Protein kinase C brain isozyme	0.006	0.0272	0.0272
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0034	0.0048	0.0048
Echinococcus multilocularis	roundabout 2	0.0032	0.0036	0.0036
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0045	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0045	0.014	0.014
Echinococcus granulosus	SH2 motif	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0036	0.0036
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.005	0.0184	0.1138
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0136	0.0136
Echinococcus granulosus	mitogen activated protein kinase 3	0.0115	0.0739	0.0739
Echinococcus granulosus	SH2 motif	0.0034	0.0048	0.0048
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0049	0.0181	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0934	0.7735	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0036	0.0036
Onchocerca volvulus		0.0034	0.0048	0.0048
Schistosoma mansoni	tyrosine kinase	0.028	0.2145	0.2154
Echinococcus granulosus	roundabout 2	0.0032	0.0036	0.0036
Schistosoma mansoni	tyrosine kinase	0.0203	0.149	0.1496
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.028	0.2145	0.2145
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.028	0.2145	0.2145
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0033	0.0037	0.0037
Brugia malayi	Animal haem peroxidase family protein	0.1188	0.9898	0.9898
Schistosoma mansoni	tyrosine kinase	0.0608	0.4948	0.497
Giardia lamblia	Kinase, STE STE20	0.0934	0.7735	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0258	0.1962	0.1962
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.014	0.0181
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	Glutaredoxin protein 5	0.0073	0.0378	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.014	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0078	0.0425	0.0427
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0934	0.7735	0.7735
Loa Loa (eye worm)	animal heme peroxidase	0.1188	0.9898	0.9898
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0045	0.014	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0458	0.3671	0.3671
Brugia malayi	SH2 domain containing protein	0.005	0.0184	0.0184
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0073	0.0378	0.0378
Echinococcus multilocularis	protein kinase c iota type	0.006	0.0272	0.0272
Echinococcus granulosus	c src tyrosine kinase	0.0078	0.0425	0.0425
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.014	0.014
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.006	0.0272	0.0272
Schistosoma mansoni	tyrosine kinase	0.0258	0.1962	0.1971
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	epidermal growth factor receptor	0.0608	0.4948	0.4948
Echinococcus granulosus	tyrosine kinase	0.0251	0.1904	0.1904
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0062	0.0289	0.0291
Schistosoma mansoni	tyrosine kinase	0.0317	0.2461	0.2472
Loa Loa (eye worm)	STAT protein	0.0034	0.0048	0.0048
Brugia malayi	MAP kinase sur-1	0.0115	0.0739	0.0739
Onchocerca volvulus		0.0305	0.236	0.2373
Schistosoma mansoni	tyrosine kinase	0.005	0.0184	0.0185
Echinococcus granulosus	serine:threonine protein kinase N2	0.0045	0.014	0.014
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0038	0.0085	0.0085
Brugia malayi	Protein kinase domain containing protein	0.005	0.0184	0.0184
Echinococcus multilocularis		0.0034	0.0048	0.0048
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0122	0.0796	0.103
Echinococcus granulosus	nervana 2	0.0073	0.0378	0.0378
Brugia malayi	Protein kinase domain containing protein	0.005	0.0184	0.0184
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0122	0.0796	0.0796
Echinococcus granulosus	SHC transforming protein 3	0.0034	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.005	0.0184	0.0184
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.028	0.2145	0.2145
Brugia malayi	Blistered cuticle protein 3	0.1188	0.9898	0.9898
Schistosoma mansoni	tensin-related	0.0034	0.0048	0.0048
Echinococcus granulosus	protein kinase c iota type	0.006	0.0272	0.0272
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0078	0.0425	0.0425
Trichomonas vaginalis	STE family protein kinase	0.0934	0.7735	1
Entamoeba histolytica	protein kinase 2, putative	0.008	0.0443	0.2745
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Brugia malayi	hypothetical protein	0.005	0.0184	0.0184
Schistosoma mansoni	tensin	0.0034	0.0048	0.0048
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0033	0.0037	0.0037
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0041	0.0113	0.07
Schistosoma mansoni	vav2	0.0054	0.0218	0.0219
Onchocerca volvulus		0.0034	0.0048	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0038	0.0085	0.0085
Brugia malayi	Tensin	0.0034	0.0048	0.0048
Onchocerca volvulus		0.1188	0.9898	0.9955
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0034	0.0048	0.0048
Echinococcus multilocularis	SH2 motif	0.0034	0.0048	0.0048
Entamoeba histolytica	protein kinase, putative	0.0117	0.0759	0.4703
Echinococcus multilocularis	tyrosine kinase	0.005	0.0184	0.0184
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0037	0.0075	0.0097
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.005	0.0184	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Echinococcus granulosus	raf serine:threonine protein kinase	0.0458	0.3671	0.3671
Onchocerca volvulus		0.0034	0.0048	0.0048
Echinococcus multilocularis	peroxidasin	0.12	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Brugia malayi	Protein kinase domain containing protein	0.005	0.0184	0.0184
Schistosoma mansoni	tyrosine kinase	0.0218	0.1622	0.1629
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Schistosoma mansoni	tensin	0.0034	0.0048	0.0048
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0034	0.0048	0.0048
Echinococcus granulosus	NDR protein kinase	0.0045	0.014	0.014
Onchocerca volvulus		0.0034	0.0048	0.0048
Schistosoma mansoni	GTPase activating protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0045	0.014	0.014
Schistosoma mansoni	protein kinase	0.0934	0.7735	0.777
Brugia malayi	protein kinase C II.	0.006	0.0272	0.0272
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0045	0.014	0.014
Onchocerca volvulus		0.1188	0.9898	0.9955
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0062	0.0289	0.0289
Trichomonas vaginalis	AGC family protein kinase	0.0122	0.0796	0.103
Onchocerca volvulus	Chorion peroxidase homolog	0.1188	0.9898	0.9955
Echinococcus multilocularis	N chimaerin	0.0049	0.0181	0.0181
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0739	0.0956
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0034	0.0048	0.0048
Trichomonas vaginalis	AGC family protein kinase	0.0049	0.0177	0.0229
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Echinococcus granulosus	protein kinase C gamma type	0.0045	0.014	0.014
Schistosoma mansoni	growth factor receptor-bound protein	0.0062	0.0289	0.0291
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0034	0.0048	0.0048
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.008	0.0443	0.0443
Brugia malayi	SRC-1	0.028	0.2145	0.2145
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0555	0.0555
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0934	0.7735	0.7735
Onchocerca volvulus	Peroxidase homolog	0.1188	0.9898	0.9955
Trypanosoma brucei	protein kinase, putative	0.0115	0.0739	0.0956
Schistosoma mansoni	suppressor of cytokine signaling	0.0034	0.0048	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0272	0.0273
Brugia malayi	Variant SH3 domain containing protein	0.0049	0.0181	0.0181
Echinococcus granulosus	dual specificity mitogen activated protein	0.0934	0.7735	0.7735
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0045	0.014	0.014
Echinococcus multilocularis	epidermal growth factor receptor	0.0332	0.2596	0.2596
Onchocerca volvulus		0.005	0.0184	0.0185
Toxoplasma gondii	AGC kinase	0.0117	0.0759	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0045	0.014	0.014
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0252	0.1911	0.1911
Echinococcus granulosus	Glutaredoxin protein 5	0.0073	0.0378	0.0378
Schistosoma mansoni	SH2A	0.0034	0.0048	0.0048
Loa Loa (eye worm)	TK protein kinase	0.0251	0.1904	0.1904
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0049	0.0181	0.0181
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0155	0.1085	0.1085
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0184	0.0184
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0235	0.1768	0.1768
Brugia malayi	Protein kinase domain containing protein	0.005	0.0184	0.0184
Loa Loa (eye worm)	blistered cuticle protein 3	0.1188	0.9898	0.9898
Brugia malayi	RhoGAP domain containing protein	0.0049	0.0181	0.0181
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0739	0.0956
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0034	0.0048	0.0048
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0266	0.2027	0.2027
Schistosoma mansoni	tyrosine kinase	0.0078	0.0425	0.0427
Echinococcus multilocularis	signal transduction protein lnk realted	0.0034	0.0048	0.0048
Entamoeba histolytica	protein kinase, putative	0.0217	0.1614	1
Schistosoma mansoni	tyrosine kinase	0.0078	0.0425	0.0427
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0235	0.1768	0.1768
Loa Loa (eye worm)	TK protein kinase	0.0217	0.1614	0.1614
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.014	0.014
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0608	0.4948	0.4948
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.014	0.014
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0934	0.7735	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0348	0.2728	0.2728
Onchocerca volvulus		0.0036	0.0065	0.0065
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0034	0.0048	0.0048
Echinococcus multilocularis	tensin	0.0034	0.0048	0.0048
Onchocerca volvulus		0.1188	0.9898	0.9955
Echinococcus granulosus	tyrosine kinase	0.005	0.0184	0.0184
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.0739	0.0956
Onchocerca volvulus	Peroxidasin homolog	0.1193	0.9943	1
Brugia malayi	Animal haem peroxidase family protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0062	0.0289	0.0289
Brugia malayi	SH2 domain containing protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0085	0.0085
Entamoeba histolytica	protein kinase, putative	0.0122	0.0796	0.4933
Schistosoma mansoni	tyrosine kinase	0.028	0.2145	0.2154
Schistosoma mansoni	tyrosine kinase	0.0332	0.2596	0.2608
Onchocerca volvulus		0.005	0.0184	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus granulosus	insulin receptor	0.0203	0.149	0.149
Schistosoma mansoni	tensin	0.0034	0.0048	0.0048
Loa Loa (eye worm)	TK/ABL protein kinase	0.0252	0.1911	0.1911
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.008	0.0443	0.5
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0934	0.7735	0.7735
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0034	0.0048	0.0048
Schistosoma mansoni	tyrosine kinase	0.0332	0.2596	0.2608
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.008	0.0443	0.0573
Schistosoma mansoni	tensin-related	0.0034	0.0048	0.0048
Brugia malayi	Animal haem peroxidase family protein	0.1188	0.9898	0.9898
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0085	0.048	0.0621
Echinococcus granulosus	twitchin	0.0033	0.0044	0.0044
Schistosoma mansoni	signal transduction protein lnk-related	0.0034	0.0048	0.0048
Echinococcus granulosus	hypothetical protein	0.0034	0.0048	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	SH2 motif	0.0034	0.0048	0.0048
Onchocerca volvulus	Peroxidase homolog	0.1188	0.9898	0.9955
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0252	0.1911	0.1911
Echinococcus multilocularis	rac serine:threonine kinase	0.0085	0.048	0.048
Loa Loa (eye worm)	SH2 domain-containing protein	0.0034	0.0048	0.0048
Schistosoma mansoni	atypical protein kinase C	0.006	0.0272	0.0273
Schistosoma mansoni	tyrosine kinase	0.0203	0.149	0.1496
Echinococcus multilocularis	serine threonine protein kinase	0.0045	0.014	0.014
Echinococcus granulosus	tyrosine protein kinase Fyn	0.028	0.2145	0.2145
Echinococcus multilocularis	nervana 2	0.0073	0.0378	0.0378
Schistosoma mansoni	adapter molecule crk	0.0062	0.0289	0.0291
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0033	0.0037	0.0037
Brugia malayi	Protein kinase domain containing protein	0.005	0.0184	0.0184
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0045	0.014	0.014
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0073	0.0378	0.0378
Echinococcus granulosus	tensin	0.0034	0.0048	0.0048
Schistosoma mansoni	tyrosine kinase	0.0317	0.2461	0.2472
Trypanosoma cruzi	Protein kinase B	0.0085	0.048	0.0621
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Brugia malayi	Animal haem peroxidase family protein	0.1193	0.9943	0.9943
Echinococcus multilocularis	NCK adaptor protein	0.0062	0.0289	0.0289
Loa Loa (eye worm)	raf kinase	0.0442	0.3535	0.3535
Echinococcus multilocularis		0.0184	0.1332	0.1332
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0739	0.0956
Echinococcus multilocularis	mitogen activated protein kinase	0.0115	0.0739	0.0739
Echinococcus granulosus	mitogen activated protein kinase	0.0115	0.0739	0.0739
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0115	0.0739	0.0739
Echinococcus multilocularis	SH2 motif	0.0034	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.12	1	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.008	0.0443	0.0443
Brugia malayi	Tyrosine-protein kinase abl-1	0.0125	0.0826	0.0826
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0934	0.7735	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0034	0.0048	0.0048
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.028	0.2145	0.2145
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.0289	0.0289
Echinococcus granulosus	growth factor receptor bound protein 2	0.0062	0.0289	0.0289
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.014	0.014
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0251	0.1904	0.1904
Loa Loa (eye worm)	hypothetical protein	0.1188	0.9898	0.9898
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.028	0.2145	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	SRC-1	0.028	0.2145	0.2145
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.008	0.0443	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0251	0.1904	0.1904
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0332	0.2596	0.2596
Schistosoma mansoni	nck2/grb4	0.0062	0.0289	0.0291
Brugia malayi	Animal haem peroxidase family protein	0.1188	0.9898	0.9898
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0287	0.221	0.221
Onchocerca volvulus		0.005	0.0184	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0048	0.0048
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0034	0.0048	0.0048
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0251	0.1904	0.1904
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0034	0.0048	0.0048
Echinococcus multilocularis	tensin	0.0034	0.0048	0.0048
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0203	0.149	0.149
Schistosoma mansoni	hypothetical protein	0.0034	0.0048	0.0048
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0739	0.0743
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0045	0.014	0.014
Echinococcus granulosus	SH2 domain containing protein 7	0.0034	0.0048	0.0048
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0034	0.0048	0.0048
Echinococcus granulosus	epidermal growth factor receptor	0.0608	0.4948	0.4948
Echinococcus multilocularis	tyrosine protein kinase shark	0.0258	0.1962	0.1962
Schistosoma mansoni	serine/threonine protein kinase	0.0458	0.3671	0.3687
Echinococcus granulosus	serine/threonine protein kinase	0.0085	0.048	0.048
Brugia malayi	Tyrosine-protein kinase abl-1	0.0155	0.1085	0.1085

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 19.7 uM	In vitro inhibition of ADP-induced aggregation of human platelets	ChEMBL.	8254619
IC50 (functional)	= 19.7 uM	In vitro inhibition of ADP-induced aggregation of human platelets	ChEMBL.	8254619

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	8254619

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 218676