Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Starlite/ChEMBL | References |
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Synaptic glycoprotein SC2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 254 aa | 208 aa | 28.9 % |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 1.2676 | 1 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.052 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 1.2676 | 1 | 1 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.052 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.3715 | 0.2628 | 0.2628 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Giardia lamblia | Protein tyrosine phosphatase | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0034 | 0.0034 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.052 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0562 | 0.0034 | 0.0034 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0562 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 1.2676 | 1 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.3715 | 0.2628 | 0.2628 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 1.2676 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0712 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.3715 | 0.2628 | 0.2628 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0562 | 0.0034 | 0.0034 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.0562 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.052 | 0 | 0.5 |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 | |
Onchocerca volvulus | 0.052 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of type 1 steroid-5-alpha-reductase | ChEMBL. | 7966146 |
IC50 (binding) | = 2 nM | Inhibition of type 1 steroid-5-alpha-reductase | ChEMBL. | 7966146 |
IC50 (binding) | = 125 nM | Inhibition of type 2 steroid-5-alpha-reductase | ChEMBL. | 7966146 |
IC50 (binding) | = 125 nM | Inhibition of type 2 steroid-5-alpha-reductase | ChEMBL. | 7966146 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.