Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0541 | 0.6959 | 1 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0166 | 0.1776 | 0.2552 |
Schistosoma mansoni | lipoxygenase | 0.013 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0029 | 0.0042 |
Brugia malayi | hypoxia-induced factor 1 | 0.0166 | 0.1776 | 0.2552 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0029 | 0.0042 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0029 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0029 | 0.0042 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 0.1278 | 0.1253 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.6959 | 1 |
Brugia malayi | hypothetical protein | 0.018 | 0.1968 | 0.2829 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0197 | 0.2203 | 0.6415 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0029 | 0.0042 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0541 | 0.6959 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0541 | 0.6959 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.004 | 0.0029 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0761 | 1 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0029 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.024 | 0.0346 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0285 | 0.3417 | 0.4911 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0541 | 0.6959 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0285 | 0.3417 | 0.4911 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0197 | 0.2203 | 0.6415 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0541 | 0.6959 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.0222 | 0.0319 |
Schistosoma mansoni | single-minded | 0.0054 | 0.0222 | 0.0222 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0029 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.024 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1348 | 0.1937 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.024 | 0.0346 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0541 | 0.6959 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0187 | 0.2064 | 0.2936 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0029 | 0.0029 |
Schistosoma mansoni | lipoxygenase | 0.0091 | 0.0737 | 0.0737 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.051 | 0.653 | 0.652 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.024 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.2987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1348 | 0.1937 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0761 | 1 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0029 | 0.0042 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Brugia malayi | hypothetical protein | 0.0135 | 0.1348 | 0.1937 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0285 | 0.3417 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.1348 | 0.1903 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.0222 | 0.0222 |
Brugia malayi | hypothetical protein | 0.0541 | 0.6959 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.051 | 0.653 | 0.652 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0029 | 0.0042 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0029 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.1348 | 0.1903 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0029 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0029 | 0.0029 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.051 | 0.653 | 0.652 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.051 | 0.653 | 0.652 |
Brugia malayi | beta-lactamase | 0.004 | 0.0029 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1968 | 0.2829 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0187 | 0.2064 | 0.6004 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.013 | 0.1278 | 0.1253 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0029 | 0.0042 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0029 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0029 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.