Activity (functional)
|
= 0
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 1
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 10 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 2
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 20 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 5
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 2.5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 5
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 9
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 17
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 10 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 18
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 2.5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 28
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 20 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 33
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 0
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 1
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 80 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 1
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 10 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 2
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 20 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 3
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 5
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 5
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 2.5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 9
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 13
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 80 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 17
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 10 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 18
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 2.5 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 19
|
Antagonism of apomorphine induced climbing was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 28
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 20 mg/kg
|
ChEMBL.
|
11462978
|
Activity (functional)
|
= 33
|
Antagonism of apomorphine induced swimming was determined in female swiss -Webster mice after (ip) administration of 40 mg/kg
|
ChEMBL.
|
11462978
|
Affinity (binding)
|
= 10 %
|
Binding affinity at dopamine receptor D2 from rat by spiropiperidone displacement.
|
ChEMBL.
|
11462978
|
IC50 (binding)
|
= 795 nM
|
Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.
|
ChEMBL.
|
11462978
|
IC50 (binding)
|
= 795 nM
|
Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.
|
ChEMBL.
|
11462978
|
No of monkeys (functional)
|
= 1
|
Number of animals showing dyskinesias was determined in haloperidol sensitized 2 cebus monkeys after (po) administration of 10 mg/kg
|
ChEMBL.
|
11462978
|
No of monkeys (functional)
|
= 1
|
Number of animals showing dyskinesias was determined in haloperidol sensitized 2 cebus monkeys after (po) administration of 20 mg/kg
|
ChEMBL.
|
11462978
|