TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.163 | Formula: C21H25N5O4S
H donors: 3 H acceptors: 5 LogP: 1.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 0
SMILES: O[C@@H]1C[C@@H](C[C@H]1COS(=O)(=O)N)n1ccc2c1ncnc2N[C@H]1CCc2c1cccc2
InChi: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19+/m0/s1
InChiKey: MPUQHZXIXSTTDU-QGWWYQLQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Echinococcus multilocularis	serotonin receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0019	0.0062	0.0184
Brugia malayi	nuclear receptor NHR-88	0.0039	0.0629	0.1203
Onchocerca volvulus		0.0025	0.023	0.0357
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.023	0.023
Brugia malayi	Steroid receptor seven-up type 2	0.0039	0.0629	0.1203
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	sulfakinin receptor protein	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0019	0.0062	0.0129
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.014	0.3357	0.699
Giardia lamblia	Kinase, CK1 Casein kinase	0.0046	0.0816	1
Schistosoma mansoni	amine GPCR	0.0025	0.023	0.023
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Schistosoma mansoni	opsin-like receptor	0.0025	0.023	0.023
Echinococcus granulosus	lamin	0.0029	0.0341	0.1015
Schistosoma mansoni	protein kinase	0.0046	0.0816	0.0816
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Schistosoma mansoni	thyroid hormone receptor	0.0039	0.0629	0.0629
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0039	0.0629	0.1203
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Onchocerca volvulus		0.0025	0.023	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0039	0.0629	0.1203
Plasmodium falciparum	NEDD8-activating enzyme E1 catalytic subunit, putative	0.0024	0.0207	0.135
Echinococcus granulosus	sex peptide receptor	0.0025	0.023	0.0685
Trypanosoma cruzi	casein kinase, putative	0.0046	0.0816	1
Onchocerca volvulus		0.0025	0.023	0.0357
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.023	0.0685
Brugia malayi	ecdysteroid receptor	0.0192	0.4776	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Trichomonas vaginalis	CK1 family protein kinase	0.0046	0.0816	0.7321
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.023	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0039	0.0629	0.1317
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.023	0.0482
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0056	0.1074	1
Echinococcus multilocularis	musashi	0.0029	0.0341	0.1015
Brugia malayi	steroid hormone receptor	0.0039	0.0629	0.1203
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.023	0.023
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	putative neuropeptide receptor	0.0025	0.023	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.023	0.0685
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus multilocularis	lamin dm0	0.0029	0.0341	0.1015
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.023	0.0685
Echinococcus granulosus	intermediate filament protein	0.0029	0.0341	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.023	0.0685
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0039	0.0629	0.0629
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.014	0.3357	0.7029
Echinococcus granulosus	NEDD8 activating enzyme E1 catalytic subunit	0.0077	0.1662	0.4949
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.0629	0.1873
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0019	0.0062	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0039	0.0629	0.1873
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.023	0.0685
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.023	0.0685
Schistosoma mansoni	retinoic acid receptor RXR	0.0039	0.0629	0.0629
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.023	0.023
Echinococcus granulosus	casein kinase I alpha	0.0046	0.0816	0.2432
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	neuropeptide receptor	0.0025	0.023	0.023
Brugia malayi	G-protein coupled receptor	0.0025	0.023	0.0357
Onchocerca volvulus		0.0025	0.023	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.0629	0.1203
Onchocerca volvulus		0.0025	0.023	0.0357
Trypanosoma brucei	NEDD8 activating enzyme subunit, putative	0.0024	0.0207	0.135
Brugia malayi	larval opioid receptor	0.0025	0.023	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.0629	0.1203
Toxoplasma gondii	NEDD8-activating enzyme E1 catalytic subunit	0.0077	0.1662	1
Brugia malayi	casein kinase I	0.0046	0.0816	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Onchocerca volvulus		0.0029	0.0341	0.0592
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.023	0.0685
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus granulosus	neuropeptide receptor	0.0025	0.023	0.0685
Echinococcus granulosus	somatostatin receptor	0.0025	0.023	0.0685
Schistosoma mansoni	nuclear receptor nhr-48	0.0019	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Trichomonas vaginalis	molybdopterin biosynthesis moeb protein, putative	0.0024	0.0207	0.0988
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Echinococcus multilocularis	FTZ F1 alpha	0.0039	0.0629	0.1873
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.023	0.0685
Onchocerca volvulus		0.0025	0.023	0.0357
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0039	0.0629	0.0629
Loa Loa (eye worm)	DR-78	0.0019	0.0062	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Brugia malayi	casein kinase 1, delta	0.0046	0.0816	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0341	0.0713
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.023	0.0685
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0077	0.1662	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0019	0.0062	0.0129
Echinococcus granulosus	fmrfamide receptor	0.0025	0.023	0.0685
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0045	0.0791	0.9642
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0112	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.023	0.0685
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.023	0.0482
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.023	0.0685
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Schistosoma mansoni	thyroid hormone receptor	0.0039	0.0629	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.0629	0.1203
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.0629	0.1203
Echinococcus multilocularis	NEDD8 activating enzyme E1 catalytic subunit	0.0077	0.1662	0.4949
Echinococcus multilocularis	somatostatin receptor	0.0025	0.023	0.0685
Echinococcus granulosus	orexin receptor type 2	0.0025	0.023	0.0685
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0046	0.0816	0.1709
Trypanosoma brucei	casein kinase I, isoform 2	0.0046	0.0816	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0019	0.0062	0.0062
Onchocerca volvulus	Huntingtin homolog	0.0133	0.3183	0.662
Schistosoma mansoni	amine GPCR	0.0025	0.023	0.023
Onchocerca volvulus		0.0029	0.0341	0.0592
Echinococcus granulosus	FTZ F1 alpha	0.0039	0.0629	0.1873
Trypanosoma cruzi	casein kinase, putative	0.0046	0.0816	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	lamin	0.0029	0.0341	0.1015
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.0629	0.1203
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0112	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Onchocerca volvulus		0.0025	0.023	0.0357
Schistosoma mansoni	amine GPCR	0.0025	0.023	0.023
Onchocerca volvulus		0.0046	0.0816	0.1601
Schistosoma mansoni	opsin-like receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Schistosoma mansoni	neuropeptide receptor	0.0025	0.023	0.023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0039	0.0629	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0122	0.0256
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.023	0.0482
Trypanosoma cruzi	casein kinase, putative	0.0046	0.0816	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.023	0.0482
Onchocerca volvulus	Bile acid receptor homolog	0.0192	0.4776	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.014	0.3357	0.7029
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.023	0.0357
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0122	0.0256
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0039	0.0629	0.1317
Trypanosoma cruzi	ubiquitin activating enzyme, putative	0.0024	0.0207	0.135
Brugia malayi	hypothetical protein	0.0021	0.0122	0.0129
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Schistosoma mansoni	hypothetical protein	0.0025	0.023	0.023
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.023	0.0685
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.023	0.023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Brugia malayi	hypothetical protein	0.0133	0.3183	0.662
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0039	0.0629	0.1873
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0039	0.0629	0.1203
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0039	0.0629	0.1203
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.023	0.0685
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0039	0.0629	0.0629
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0046	0.0816	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.014	0.3357	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0122	0.0129
Brugia malayi	ORL1-like opioid receptor	0.0025	0.023	0.0357
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Echinococcus multilocularis	casein kinase I alpha	0.0046	0.0816	0.2432
Echinococcus granulosus	nuclear receptor nhr 48	0.0019	0.0062	0.0184
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.023	0.0685
Echinococcus granulosus	hypothetical protein	0.0025	0.023	0.0685
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.023	0.0685
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0039	0.0629	0.0629
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0039	0.0629	0.0629
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0062	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0019	0.0062	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Plasmodium vivax	ubiquitin-activating enzyme E1C, putative	0.0024	0.0207	0.135
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0039	0.0629	0.1317
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0021	0.0122	0.0256
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0062	0.0184
Brugia malayi	G protein-coupled receptor	0.0025	0.023	0.0357
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.023	0.0685
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.023	0.0482
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.023	0.0357
Echinococcus granulosus	g protein coupled receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus granulosus	ecdysone induced protein 78C	0.0039	0.0629	0.1873
Schistosoma mansoni	amine GPCR	0.0025	0.023	0.023
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.023	0.023
Trypanosoma cruzi	casein kinase, putative	0.0046	0.0816	1
Echinococcus granulosus	allatostatin A receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	casein kinase I alpha	0.0046	0.0816	0.2432
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.023	0.0482
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.023	0.0685
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.023	0.0685
Plasmodium vivax	casein kinase 1, putative	0.0046	0.0816	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4776	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	neuropeptide receptor	0.0025	0.023	0.023
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.023	0.023
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0046	0.0816	0.1709
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.023	0.0685
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	ectopic membrane ruffles in embryo protein 1	0.0077	0.1662	0.3479
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0039	0.0629	0.1873
Onchocerca volvulus		0.0025	0.023	0.0357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.023	0.0685
Echinococcus granulosus	casein kinase I delta	0.0046	0.0816	0.2432
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	lamin dm0	0.0029	0.0341	0.1015
Echinococcus multilocularis	casein kinase i	0.0046	0.0816	0.2432
Echinococcus granulosus	thyroid hormone receptor alpha	0.0019	0.0062	0.0184
Schistosoma mansoni	RAR-like nuclear receptor	0.0039	0.0629	0.0629
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0039	0.0629	0.1873
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0039	0.0629	0.1203
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.023	0.023
Brugia malayi	Ectopic membrane ruffles in embryo protein 1	0.0077	0.1662	0.3394
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.023	0.0357
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.023	0.023
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.023	0.0685
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.023	0.0685
Brugia malayi	AKH receptor	0.0025	0.023	0.0357
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.023	0.0357
Echinococcus granulosus	casein kinase I alpha	0.0046	0.0816	0.2432
Brugia malayi	Dopamine receptor protein 2	0.0025	0.023	0.0357
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0112	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0112	0.5
Brugia malayi	nuclear hormone receptor	0.0039	0.0629	0.1203
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.014	0.3357	1
Brugia malayi	Serotonin receptor	0.0025	0.023	0.0357
Brugia malayi	Dopamine receptor	0.0025	0.023	0.0357
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0341	0.0713
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0155	0.3777	0.7881
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0062	0.0184
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0112	0.5
Echinococcus granulosus	serotonin receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.023	0.0685
Brugia malayi	Dopamine receptor protein 1	0.0025	0.023	0.0357
Schistosoma mansoni	hypothetical protein	0.0025	0.023	0.023
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0155	0.3777	0.7908
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0122	0.0256
Plasmodium falciparum	casein kinase 1	0.0046	0.0816	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0112	0.0333
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.023	0.0685
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.023	0.023
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0021	0.0122	0.0365
Schistosoma mansoni	nuclear receptor	0.0019	0.0062	0.0062
Echinococcus granulosus	casein kinase I alpha	0.0046	0.0816	0.2432
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.023	0.0357
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0039	0.0629	0.1203
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Onchocerca volvulus		0.0025	0.023	0.0357
Trypanosoma cruzi	casein kinase, putative	0.0046	0.0816	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.023	0.0685
Entamoeba histolytica	casein kinase, putative	0.0046	0.0816	0.4546
Brugia malayi	RE15519p	0.0025	0.023	0.0357
Trichomonas vaginalis	CK1 family protein kinase	0.0046	0.0816	0.7321
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	nuclear receptor nhr 48	0.0019	0.0062	0.0184
Schistosoma mansoni	lamin	0.0029	0.0341	0.0341
Echinococcus granulosus	casein kinase i	0.0046	0.0816	0.2432
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0062	0.0062
Schistosoma mansoni	ap endonuclease	0.002	0.0112	0.0112
Schistosoma mansoni	nuclear receptor	0.0019	0.0062	0.0062
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.023	0.0685
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.023	0.0685
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.023	0.0685
Schistosoma mansoni	lamin	0.0029	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.023	0.0685
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.023	0.0357
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.0629	0.1873
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.023	0.0685
Schistosoma mansoni	biogenic amine receptor	0.0025	0.023	0.023
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.023	0.0685
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.023	0.0685
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0021	0.0122	0.0365
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0039	0.0629	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0133	0.3183	0.6663
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	sex peptide receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	casein kinase I alpha	0.0046	0.0816	0.2432
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.023	0.023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0039	0.0629	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	biogenic amine receptor	0.0025	0.023	0.023
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0816	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	intermediate filament protein	0.0029	0.0341	0.0592
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0062	0.0062
Echinococcus granulosus	g protein coupled receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Brugia malayi	photoreceptor-specific nuclear receptor	0.0039	0.0629	0.1203
Onchocerca volvulus		0.0025	0.023	0.0357
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.023	0.0685
Schistosoma mansoni	neuropeptide receptor	0.0025	0.023	0.023
Onchocerca volvulus		0.0025	0.023	0.0357
Schistosoma mansoni	opsin-like receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus multilocularis	serotonin receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0629	0.1203
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Onchocerca volvulus		0.0039	0.0629	0.1203
Schistosoma mansoni	myosin xvIII	0.0025	0.023	0.023
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0122	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Brugia malayi	neuropeptide F receptor	0.0025	0.023	0.0357
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0122	0.0256
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.023	0.0482
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0039	0.0629	0.1317
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0062	0.0184
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.023	0.0685
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.0629	0.1873
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.023	0.0685
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Onchocerca volvulus		0.0025	0.023	0.0357
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0112	0.0234
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.023	0.0685
Onchocerca volvulus		0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Schistosoma mansoni	hypothetical protein	0.0025	0.023	0.023
Schistosoma mansoni	zinc finger protein	0.0019	0.0062	0.0062
Toxoplasma gondii	casein kinase I	0.0046	0.0816	0.4546
Echinococcus multilocularis	casein kinase I delta	0.0046	0.0816	0.2432
Brugia malayi	Melatonin receptor type 1A	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0133	0.3183	0.6663
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Onchocerca volvulus	Protein ultraspiracle homolog	0.0039	0.0629	0.1203
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.023	0.023
Brugia malayi	GnHR receptor homolog	0.0025	0.023	0.0357
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0039	0.0629	0.1873
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0039	0.0629	0.0629
Echinococcus multilocularis	casein kinase I delta	0.0046	0.0816	0.2432
Echinococcus multilocularis	ecdysone induced protein 78C	0.0039	0.0629	0.1873
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.0629	0.1873
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.023	0.023
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.023	0.0685
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0039	0.0629	0.1873
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0039	0.0629	0.1873
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0039	0.0629	0.1203
Schistosoma mansoni	ubiquitin-activating enzyme E1C	0.0077	0.1662	0.1662
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.023	0.023
Loa Loa (eye worm)	steroid hormone receptor	0.0039	0.0629	0.1317
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0039	0.0629	0.1317
Trichomonas vaginalis	CK1 family protein kinase	0.0046	0.0816	0.7321
Schistosoma mansoni	adenoreceptor	0.0025	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.0629	0.1203
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.023	0.0685
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.023	0.0685
Schistosoma mansoni	hypothetical protein	0.0025	0.023	0.023
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.023	0.0685
Brugia malayi	neuropeptide F receptor	0.0025	0.023	0.0357
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0062	0.0184
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0039	0.0629	0.1873
Brugia malayi	hypothetical protein	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.023	0.023
Leishmania major	casein kinase, putative	0.0046	0.0816	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0629	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0326	0.0683
Onchocerca volvulus		0.0025	0.023	0.0357
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0112	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.023	0.0685
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.023	0.0357
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Schistosoma mansoni	histamine h1 receptor	0.0025	0.023	0.023
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0039	0.0629	0.1317
Onchocerca volvulus		0.0045	0.0791	0.1547
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0021	0.0122	0.0122
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0341	0.0592
Entamoeba histolytica	casein kinase 1, putative	0.0046	0.0816	0.4546
Schistosoma mansoni	nuclear hormone receptor	0.0039	0.0629	0.0629
Leishmania major	ubiquitin activating enzyme, putative	0.0024	0.0207	0.135
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	hypothetical protein	0.0021	0.0122	0.0129
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.023	0.0357
Schistosoma mansoni	coup transcription factor	0.0039	0.0629	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.023	0.0685
Trypanosoma cruzi	ubiquitin activating enzyme, putative	0.0024	0.0207	0.135
Echinococcus granulosus	casein kinase I delta	0.0046	0.0816	0.2432
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0019	0.0062	0.0129
Schistosoma mansoni	biogenic amine receptor	0.0025	0.023	0.023
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.023	0.0685
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.023	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Echinococcus granulosus	neuropeptide receptor	0.0025	0.023	0.0685
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0062	0.0184
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Onchocerca volvulus		0.0025	0.023	0.0357
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0046	0.0816	0.1709
Brugia malayi	nuclear receptor RXR	0.0021	0.0122	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Schistosoma mansoni	ap endonuclease	0.002	0.0112	0.0112
Brugia malayi	Serotonin receptor	0.0025	0.023	0.0357
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0039	0.0629	0.1873
Schistosoma mansoni	serine/threonine protein kinase	0.0155	0.3777	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0039	0.0629	0.1203
Echinococcus granulosus	g protein coupled receptor	0.0025	0.023	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.023	0.023
Onchocerca volvulus		0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0062	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Onchocerca volvulus		0.0025	0.023	0.0357
Brugia malayi	G-protein coupled receptor	0.0025	0.023	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0122	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0025	0.023	0.0482
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0341	0.0713
Schistosoma mansoni	amine GPCR	0.0025	0.023	0.023
Onchocerca volvulus	Huntingtin homolog	0.0133	0.3183	0.662

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3856065

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2203954