Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0064 | 0.0008 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0025 | 0.0768 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0025 | 0.0768 | 0.1111 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0015 | 0.0064 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0015 | 0.0064 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.1413 | 0.1933 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0025 | 0.0768 | 0.1111 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0025 | 0.0768 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1413 | 0.1365 |
Entamoeba histolytica | ABC transporter, putative | 0.0015 | 0.0064 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0034 | 0.1413 | 0.1933 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0021 | 0.0486 | 0.0604 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0095 | 0.5625 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0015 | 0.0064 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0768 | 0.0716 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0034 | 0.1413 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.5473 | 0.5448 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0064 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0015 | 0.0064 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0015 | 0.0064 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0015 | 0.0064 | 0.5 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0025 | 0.0768 | 0.1111 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.7046 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0095 | 0.5625 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0015 | 0.0064 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0025 | 0.0768 | 0.1009 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0025 | 0.0768 | 0.1111 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0015 | 0.0064 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0077 | 0.4382 | 0.6814 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0025 | 0.0768 | 0.1111 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0768 | 0.1009 |
Trypanosoma brucei | multidrug resistance protein E | 0.0015 | 0.0064 | 0.5 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0025 | 0.0768 | 0.0716 |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0064 | 0.5 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0025 | 0.0768 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0034 | 0.1413 | 0.2129 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0025 | 0.0768 | 0.1009 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0025 | 0.0768 | 0.1111 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0025 | 0.0768 | 0.1009 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.7046 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0025 | 0.0768 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0064 | 0.0008 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0025 | 0.0768 | 0.1111 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0064 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0107 | 0.6401 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0077 | 0.4382 | 0.6814 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0077 | 0.4382 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0025 | 0.0768 | 0.1009 |
Trypanosoma brucei | p-glycoprotein | 0.0015 | 0.0064 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0107 | 0.6401 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0159 | 1 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0015 | 0.0064 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0159 | 1 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0025 | 0.0768 | 0.1111 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0015 | 0.0064 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0486 | 0.0604 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0077 | 0.4382 | 0.6814 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0015 | 0.0064 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0034 | 0.1413 | 0.2129 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0107 | 0.6401 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0015 | 0.0064 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0107 | 0.6401 | 0.638 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0025 | 0.0768 | 0.0716 |
Echinococcus granulosus | voltage gated potassium channel | 0.0034 | 0.1413 | 0.2129 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0034 | 0.1413 | 0.2129 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0025 | 0.0768 | 0.1111 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0015 | 0.0064 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | In vitro antimicrobial activity against penicillin-intermediate S. pneumoniae 49619 | ChEMBL. | 12930152 |
MIC (functional) | > 32 ug ml-1 | In vitro antimicrobial activity against methicillin resistant S. aureus 27660 | ChEMBL. | 12930152 |
MIC (functional) | > 32 ug ml-1 | In vitro antimicrobial activity against vancomycin-susceptible E. faecalis 29212 | ChEMBL. | 12930152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.