Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin-like modifier activating enzyme 3 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | app binding protein | 0.0054 | 0.1609 | 0.018 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0087 | 0.4141 | 1 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0086 | 0.4095 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0054 | 0.1609 | 0.2254 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0065 | 0.2421 | 0.1526 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0087 | 0.4141 | 0.3017 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0065 | 0.2421 | 1 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0163 | 1 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0065 | 0.2421 | 0.2421 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0054 | 0.1609 | 0.2254 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0054 | 0.1609 | 0.3929 |
Toxoplasma gondii | hypothetical protein | 0.0065 | 0.2421 | 0.3205 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0086 | 0.4095 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0126 | 0.714 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0065 | 0.2469 | 0.3458 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.0126 | 0.714 | 0.6591 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0087 | 0.4141 | 0.3017 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0163 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0049 | 0.1188 | 0.2902 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0163 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0087 | 0.4141 | 0.3017 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0065 | 0.2421 | 0.0967 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0061 | 0.2131 | 0.5203 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.01 | 0.5175 | 0.6093 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0087 | 0.4141 | 0.3017 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.2421 | 0.0967 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.0086 | 0.4095 | 0.5 |
Loa Loa (eye worm) | ube1-prov protein | 0.0163 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.1609 | 0.3929 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0086 | 0.4095 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0087 | 0.4141 | 0.3017 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0051 | 0.1372 | 0.1922 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0163 | 1 | 1 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0163 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0056 | 0.1739 | 0.2436 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0087 | 0.4141 | 0.4378 |
Brugia malayi | ThiF family protein | 0.0065 | 0.2421 | 0.0967 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.01 | 0.5175 | 0.6093 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0065 | 0.2421 | 0.0967 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0086 | 0.4095 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0126 | 0.714 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0131 | 0.7531 | 1 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0061 | 0.2131 | 0.5203 |
Trypanosoma brucei | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0054 | 0.1609 | 0.3929 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.0126 | 0.714 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | <= 0.1 uM | Inhibition of recombinant human untagged NAEalpha/N-terminal His-tagged NAEbeta expressed in Bac-to-Bac expression system using FLAG-tagged NEDD8 as substrate after 90 mins in presence of GST-tagged Ubc12 by HTRF assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.