Detailed information for compound 223192

Basic information

Technical information
  • TDR Targets ID: 223192
  • Name: 2-(2-chloroethyl)-1-hydroxy-9-oxa-2,5-diaza-1 $l^{5}-phosphacyclononane 1-oxide
  • MW: 242.64 | Formula: C7H16ClN2O3P
  • H donors: 2 H acceptors: 2 LogP: -2.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN1CCNCCCOP1(=O)O
  • InChi: 1S/C7H16ClN2O3P/c8-2-5-10-6-4-9-3-1-7-13-14(10,11)12/h9H,1-7H2,(H,11,12)
  • InChiKey: SIMWMEHPUXRDQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-chloroethyl)-2-hydroxy-1-oxa-3,6-diaza-2$l^{5}-phosphacyclononane 2-oxide
  • 158401-52-6
  • 1,3,6,2-Oxadiazaphosphonine, octahydro-3-(2-chloroethyl)-2-hydroxy-, 2-oxide
  • 3-(2-Chloroethyl)-2-hydroxy-1,3,6,2-oxadiazaphosphonane 2-oxide
  • Octahydro-3-(2-chloroethyl)-2-hydroxy-1,3,6,2-oxadiazaphosphonine 2-oxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.2777 0.2777
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.2518 0.1929
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0769 0.0769
Schistosoma mansoni neuropeptide receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.2518 0.2518
Brugia malayi protein-tyrosine kinase 0.007 0.3259 0.3312
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0769 0.0769
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.2518 0.1929
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.2518 0.2559
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) TK protein kinase 0.0062 0.2777 0.2176
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.3259 0.3259
Onchocerca volvulus 0.0058 0.2518 0.1929
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.2518 0.2518
Brugia malayi GnHR receptor homolog 0.0058 0.2518 0.2559
Echinococcus multilocularis fmrfamide receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0769 0.0769
Onchocerca volvulus 0.0058 0.2518 0.1929
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Brugia malayi Serotonin receptor 0.0058 0.2518 0.2559
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.2518 0.2518
Schistosoma mansoni neuropeptide receptor 0.0058 0.2518 0.2518
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.2518 0.2559
Schistosoma mansoni biogenic amine (5HT) receptor 0.0179 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 0.2518 0.2518
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0769 0.0769
Schistosoma mansoni tyrosine kinase 0.0078 0.3728 0.3728
Echinococcus granulosus neuropeptide receptor 0.0058 0.2518 0.2518
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.0781
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0078 0.3728 0.3728
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0078 0.3728 0.3728
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptide receptor A26 0.0058 0.2518 0.2518
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.2518 0.1895
Schistosoma mansoni biogenic amine receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0176 0.9838 0.9824
Brugia malayi neuropeptide F receptor 0.0058 0.2518 0.2559
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.2518 0.2518
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.0769 0.0769
Echinococcus granulosus tyrosine kinase 0.007 0.3259 0.3259
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Onchocerca volvulus 0.0058 0.2518 0.1929
Onchocerca volvulus 0.0176 0.9838 1
Plasmodium vivax amine transporter, putative 0.003 0.0769 0.5
Echinococcus granulosus somatostatin receptor 0.0058 0.2518 0.2518
Brugia malayi neuropeptide F receptor 0.0058 0.2518 0.2559
Loa Loa (eye worm) hypothetical protein 0.0176 0.9838 0.9824
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.2518 0.2559
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.2518 0.2518
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.0769 0.0769
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.2518 0.2518
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.2518 0.2559
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.003 0.0769 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni opsin-like receptor 0.0058 0.2518 0.2518
Brugia malayi G-protein coupled receptor 0.0058 0.2518 0.2559
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.2518 0.2559
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2518 0.2518
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.3259 0.3259
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus allatostatin A receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.0781
Schistosoma mansoni hypothetical protein 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.2518 0.2518
Brugia malayi follicle stimulating hormone receptor 0.0058 0.2518 0.2559
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Brugia malayi AKH receptor 0.0058 0.2518 0.2559
Echinococcus multilocularis sex peptide receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis serotonin transporter 0.0176 0.9838 0.9838
Schistosoma mansoni myosin xvIII 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni neuropeptide receptor 0.0058 0.2518 0.2518
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.0769 0.0781
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) solute carrier family 6 member 4 0.0176 0.9838 0.9824
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.2518 0.1895
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Schistosoma mansoni sodium/chloride dependent transporter 0.0176 0.9838 0.9838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni amine GPCR 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2518 0.2518
Brugia malayi putative neuropeptide receptor 0.0058 0.2518 0.2559
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.2518 0.1895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.2518 0.1895
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.0769 0.0769
Loa Loa (eye worm) SRC-1 0.0078 0.3728 0.3206
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.3728 0.3728
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.2518 0.2518
Brugia malayi sulfakinin receptor protein 0.0058 0.2518 0.2559
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.2518 0.2518
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0769 0.0769
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.2518 0.1895
Echinococcus multilocularis allatostatin A receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.2518 0.1895
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.2518 0.2518
Echinococcus granulosus tyrosine protein kinase Src64B 0.0078 0.3728 0.3728
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Plasmodium vivax hypothetical protein, conserved 0.003 0.0769 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2518 0.2518
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.2518 0.1895
Brugia malayi Serotonin receptor 0.0058 0.2518 0.2559
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.3728 0.3728
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Brugia malayi Dopamine receptor 0.0058 0.2518 0.2559
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0769 0.0769
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2518 0.2518
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.2518 0.2518
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus sex peptide receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0078 0.3728 0.3728
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.2518 0.2518
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.3124 0.3124
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Onchocerca volvulus 0.0058 0.2518 0.1929
Plasmodium falciparum transporter, putative 0.003 0.0769 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Brugia malayi larval opioid receptor 0.0058 0.2518 0.2559
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.5
Schistosoma mansoni histamine h1 receptor 0.0058 0.2518 0.2518
Entamoeba histolytica protein kinase, putative 0.0062 0.2777 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.2518 0.2518
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.3124 0.3124
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.0769 0.0769
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptide s receptor 0.0058 0.2518 0.2518
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.5
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2518 0.2518
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.2518 0.2559
Schistosoma mansoni amine GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni hypothetical protein 0.0058 0.2518 0.2518
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptide receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Brugia malayi Dopamine receptor protein 1 0.0058 0.2518 0.2559
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis fmrfamide receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0179 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.2518 0.2518
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2518 0.2518
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus g protein coupled receptor 0.0058 0.2518 0.2518
Echinococcus granulosus fmrfamide receptor 0.0058 0.2518 0.2518
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni tyrosine kinase 0.0078 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni biogenic amine receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2518 0.2518
Brugia malayi RE15519p 0.0058 0.2518 0.2559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.3259 0.3259
Schistosoma mansoni amine GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) serotonin transporter b 0.0176 0.9838 0.9824
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0078 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.3259 0.3259
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.2518 0.2518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.2518 0.1895
Brugia malayi Dopamine receptor protein 2 0.0058 0.2518 0.2559
Schistosoma mansoni biogenic amine receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.2518 0.1895
Schistosoma mansoni amine GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.2518 0.2518
Treponema pallidum sodium- and chloride- dependent transporter 0.0176 0.9838 0.5
Onchocerca volvulus 0.0058 0.2518 0.1929
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.2518 0.2518
Schistosoma mansoni neuropeptide receptor 0.0058 0.2518 0.2518
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.0769 0.0769
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.2518 0.2518
Echinococcus granulosus g protein coupled receptor 0.0058 0.2518 0.2518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Brugia malayi G-protein coupled receptor 0.0058 0.2518 0.2559
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.0769 0.0769
Echinococcus multilocularis neuropeptide receptor 0.0058 0.2518 0.2518
Brugia malayi ORL1-like opioid receptor 0.0058 0.2518 0.2559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus multilocularis g protein coupled receptor 0.0058 0.2518 0.2518
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.2518 0.2518
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.2518 0.2518
Echinococcus granulosus g protein coupled receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.2518 0.2518
Echinococcus granulosus orexin receptor type 2 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Brugia malayi G protein-coupled receptor 0.0058 0.2518 0.2559
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0078 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.2518 0.2518
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.0769 0.0769
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.2518 0.2559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.2518 0.2518
Onchocerca volvulus 0.0058 0.2518 0.1929
Schistosoma mansoni amine GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis orexin receptor type 2 0.0058 0.2518 0.2518
Echinococcus granulosus g-protein coupled receptor 0.0058 0.2518 0.2518
Schistosoma mansoni adenoreceptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.2518 0.2518
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0176 0.9838 0.9838
Echinococcus multilocularis neuropeptide receptor A26 0.0058 0.2518 0.2518
Echinococcus granulosus tyrosine protein kinase Lyn 0.0078 0.3728 0.3728
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 0.2518 0.2518
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.0769 0.0781
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Loa Loa (eye worm) TK protein kinase 0.007 0.3259 0.2697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.2518 0.2518
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.2518 0.2518
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2518 0.2518
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.2518 0.2518
Schistosoma mansoni hypothetical protein 0.0058 0.2518 0.2518
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0078 0.3728 0.3728
Loa Loa (eye worm) norepinephrine transporter 0.0176 0.9838 0.9824
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.3728 0.3728
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.2518 0.2518
Echinococcus granulosus serotonin receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.2518 0.2518
Plasmodium falciparum amino acid transporter, putative 0.003 0.0769 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.2518 0.2518
Schistosoma mansoni opsin-like receptor 0.0058 0.2518 0.2518
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.0769 0.0769
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0176 0.9838 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.0769 0.0769
Echinococcus granulosus hypothetical protein 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Brugia malayi Melatonin receptor type 1A 0.0058 0.2518 0.2559
Toxoplasma gondii hypothetical protein 0.003 0.0769 0.5
Brugia malayi hypothetical protein 0.003 0.0769 0.0781
Loa Loa (eye worm) hypothetical protein 0.0176 0.9838 0.9824
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis neuropeptide receptor 0.0058 0.2518 0.2518
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.3259 0.3259
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0769 0.0769
Echinococcus multilocularis neuropeptide s receptor 0.0058 0.2518 0.2518
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.2518 0.2518
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.2518 0.1895
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.2518 0.2559
Echinococcus granulosus serotonin transporter 0.0176 0.9838 0.9838
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0078 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus multilocularis serotonin receptor 0.0179 1 1
Echinococcus multilocularis somatostatin receptor 0.0058 0.2518 0.2518
Brugia malayi SRC-1 0.0078 0.3728 0.379
Onchocerca volvulus 0.0058 0.2518 0.1929
Brugia malayi hypothetical protein 0.0058 0.2518 0.2559
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.0058 0.2518 0.1895
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.2777 0.2777
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.0769 0.0769
Onchocerca volvulus 0.0058 0.2518 0.1929
Echinococcus multilocularis serotonin receptor 0.0179 1 1
Toxoplasma gondii hypothetical protein 0.003 0.0769 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.2518 0.2518
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.2518 0.2518
Schistosoma mansoni opsin-like receptor 0.0058 0.2518 0.2518
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.2518 0.2518
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.0769 0.0769

Activities

Activity type Activity value Assay description Source Reference
Efficacy (functional) 0 Antitumor efficacy evaluated after single dose of 316 mg/kg; NE = No effect ChEMBL. 7966159
Efficacy (functional) 0 Antitumor efficacy evaluated after fractionated dose of 4*100 mg/kg; NE = No effect ChEMBL. 7966159
LD50 (ADMET) = 1000 mg kg-1 Lethal dose of the compound was evaluated after single intraperitoneal injection of the compound in mice ChEMBL. 7966159
LD50 (ADMET) = 1000 mg kg-1 Lethal dose of the compound was evaluated after single intraperitoneal injection of the compound in mice ChEMBL. 7966159

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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