TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 245.199 | Formula: C13H27NO3
H donors: 3 H acceptors: 3 LogP: 1.97 Rotable bonds: 7
Rule of 5 violations (Lipinski): 0
SMILES: CCCCCCCN1CC[C@@H]([C@H]([C@@H]1CO)O)O
InChi: InChI=1S/C13H27NO3/c1-2-3-4-5-6-8-14-9-7-12(16)13(17)11(14)10-15/h11-13,15-17H,2-10H2,1H3/t11-,12-,13-/m0/s1
InChiKey: QAGIKQNJARYAFD-AVGNSLFASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucosidase, beta, acid		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Brugia malayi	O-Glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Onchocerca volvulus	Glucosylceramidase homolog	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0194	0.0194
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0106	0.0432	0.3093
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0075	0.0189	0.1245
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.0427	0.2077
Brugia malayi	Dopamine receptor protein 1	0.0075	0.0189	0.0917
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0075	0.0189	0.1245
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0075	0.0189	0.0189
Brugia malayi	Dopamine receptor	0.0075	0.0189	0.0917
Echinococcus granulosus	tfiia large subunit	0.0106	0.0435	0.3116
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.0087	0.0382
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0178	0.1003	0.4874
Echinococcus granulosus	tm gpcr rhodopsin	0.0075	0.0189	0.1245
Loa Loa (eye worm)	neuropeptide F receptor	0.0075	0.0189	0.0189
Brugia malayi	ORL1-like opioid receptor	0.0075	0.0189	0.0917
Echinococcus granulosus	Mastin	0.0069	0.0136	0.0843
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Brugia malayi	larval opioid receptor	0.0075	0.0189	0.0917
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0055	0.0025	0.0121
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0106	0.0432	0.2099
Brugia malayi	putative neuropeptide receptor NPR1	0.0075	0.0189	0.0917
Brugia malayi	G protein-coupled receptor	0.0075	0.0189	0.0917
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0184	0.1517
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Echinococcus multilocularis	somatostatin receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.2059	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	melatonin receptor type 1A	0.0075	0.0189	0.0189
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0106	0.0432	1
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0221	0.1342	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	7TM GPCR rhodopsin	0.0075	0.0189	0.1245
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	opsin-like receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	adenoreceptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Onchocerca volvulus		0.0062	0.0087	0.072
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0221	0.1342	1
Onchocerca volvulus		0.0075	0.0189	0.1559
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0106	0.0432	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	immunophilin	0.0106	0.0432	0.3093
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0178	0.1003	0.7431
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0091	0.0317	0.2216
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.0427	0.2077
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0076	0.0194	0.1285
Echinococcus granulosus	lysosomal alpha glucosidase	0.0178	0.1003	0.7431
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0075	0.0189	0.1245
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0261	0.1657	1
Schistosoma mansoni	opsin-like receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus granulosus	tm gpcr rhodopsin	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0189	0.1245
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0075	0.0189	0.0917
Brugia malayi	Kringle domain containing protein	0.0062	0.0087	0.0424
Loa Loa (eye worm)	hypothetical protein	0.018	0.1016	0.1016
Brugia malayi	Transcription factor IIA, alpha/beta subunit family protein	0.0106	0.0435	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0016	0.0016
Echinococcus multilocularis	G protein coupled receptor 139	0.0075	0.0189	0.1245
Trichomonas vaginalis	fk506-binding protein, putative	0.0106	0.0432	0.2002
Brugia malayi	neuropeptide F receptor	0.0075	0.0189	0.0917
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0189	0.1245
Brugia malayi	Protein kinase domain containing protein	0.0062	0.0087	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Onchocerca volvulus		0.0075	0.0189	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0075	0.0189	0.1245
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0178	0.1003	0.7431
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	alpha-glucosidase	0.0144	0.0733	0.5376
Schistosoma mansoni	amine GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0224	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0125	0.0584	0.4247
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0427	0.0427
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0106	0.0432	0.2002
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0189	0.1245
Brugia malayi	putative neuropeptide receptor	0.0075	0.0189	0.0917
Schistosoma mansoni	neuropeptide F-like receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0075	0.0189	0.1245
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	serotonin receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0055	0.0025	0.0058
Brugia malayi	follicle stimulating hormone receptor	0.0075	0.0189	0.0917
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0106	0.0432	0.3093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Brugia malayi	AKH receptor	0.0075	0.0189	0.0917
Echinococcus multilocularis	tfiia large subunit	0.0106	0.0435	0.3116
Loa Loa (eye worm)	TK/ROR protein kinase	0.0062	0.0087	0.0087
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Brugia malayi	Muscle positioning protein 4	0.0053	0.0016	0.0075
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.2059	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0069	0.0136	0.0843
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0106	0.0432	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0124	0.057	0.3341
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.0432	0.2494
Echinococcus granulosus	neuropeptide receptor A26	0.0075	0.0189	0.1245
Echinococcus granulosus	fmrfamide receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Leishmania major	mitochondrial DNA polymerase beta	0.0261	0.1657	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Brugia malayi	acetyltransferase, GNAT family protein	0.0125	0.0584	0.2837
Trichomonas vaginalis	immunophilin, putative	0.0106	0.0432	0.2002
Echinococcus multilocularis	neuropeptides capa receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.018	0.1016	0.7526
Mycobacterium ulcerans	hypothetical protein	0.0138	0.0681	1
Echinococcus multilocularis	enteropeptidase	0.0069	0.0136	0.0843
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Schistosoma mansoni	amine GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	allatostatin A receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0221	0.1342	1
Schistosoma mansoni	tfiia large subunit	0.0106	0.0435	0.3116
Echinococcus multilocularis	sex peptide receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0317	0.0317
Schistosoma mansoni	histamine h1 receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	amine GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	hypothetical protein	0.0075	0.0189	0.1245
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0075	0.0189	0.1245
Loa Loa (eye worm)	G-protein coupled receptor	0.0075	0.0189	0.0189
Schistosoma mansoni	opsin-like receptor	0.0075	0.0189	0.1245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0261	0.1657	1
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0164	0.0164
Echinococcus granulosus	G protein coupled receptor 139	0.0075	0.0189	0.1245
Echinococcus granulosus	tm gpcr rhodopsin	0.0075	0.0189	0.1245
Toxoplasma gondii	kringle domain-containing protein	0.0062	0.0087	0.0203
Toxoplasma gondii	melibiase subfamily protein	0.0221	0.1342	0.3121
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Onchocerca volvulus		0.0075	0.0189	0.1559
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.0432	0.2494
Echinococcus granulosus	g-protein coupled receptor	0.0075	0.0189	0.1245
Brugia malayi	Serotonin receptor	0.0075	0.0189	0.0917
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	allatostatin A receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	neuropeptide Y receptor	0.0075	0.0189	0.1245
Brugia malayi	sulfakinin receptor protein	0.0075	0.0189	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0009	0.0009
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0075	0.0189	0.0917
Onchocerca volvulus		0.0075	0.0189	0.1559
Brugia malayi	Trypsin family protein	0.0076	0.0194	0.0942
Echinococcus granulosus	7tm_1 domain containing protein	0.0075	0.0189	0.1245
Echinococcus multilocularis	fmrfamide receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0075	0.0189	0.1245
Brugia malayi	Melatonin receptor type 1A	0.0075	0.0189	0.0917
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0075	0.0189	0.0917
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0091	0.0317	0.2216
Echinococcus granulosus	neuropeptide receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0075	0.0189	0.1245
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0106	0.0432	0.3093
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0075	0.0189	0.1245
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0075	0.0189	0.0189
Loa Loa (eye worm)	G-protein coupled receptor	0.0075	0.0189	0.0189
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.0432	0.2494
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Toxoplasma gondii	PAN domain-containing protein	0.0595	0.4298	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0075	0.0189	0.0917
Brugia malayi	neuropeptide F receptor	0.0075	0.0189	0.0917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Loa Loa (eye worm)	acetyltransferase	0.0125	0.0584	0.0584
Echinococcus multilocularis	orexin receptor type 2	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0106	0.0432	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	hypothetical protein	0.0062	0.0087	0.0474
Echinococcus granulosus	neuropeptide Y receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	somatostatin receptor	0.0075	0.0189	0.1245
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0075	0.0189	0.1245
Echinococcus multilocularis	neuropeptide receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	immunophilin	0.0091	0.0317	0.2216
Echinococcus granulosus	neuropeptide receptor	0.0075	0.0189	0.1245
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0261	0.1657	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.0427	0.0427
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Brugia malayi	Dopamine receptor protein 2	0.0075	0.0189	0.0917
Onchocerca volvulus		0.0075	0.0189	0.1559
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.018	0.1016	0.7526
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Echinococcus multilocularis	neuropeptide s receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus multilocularis	neuropeptide Y receptor	0.0075	0.0189	0.1245
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0075	0.0189	0.1245
Loa Loa (eye worm)	FKBP5 protein	0.0106	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Echinococcus granulosus	neuropeptides capa receptor	0.0075	0.0189	0.1245
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0075	0.0189	0.1559
Onchocerca volvulus		0.0075	0.0189	0.1559
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0189	0.1245
Toxoplasma gondii	PAN domain-containing protein	0.0595	0.4298	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0075	0.0189	0.1245
Leishmania major	hypothetical protein, conserved	0.0062	0.0087	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	immunophilin	0.0106	0.0432	0.3093
Schistosoma mansoni	myosin xvIII	0.0075	0.0189	0.1245
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0125	0.0584	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0221	0.1342	1
Schistosoma mansoni	amine GPCR	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0075	0.0189	0.1245
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0164	0.0795
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0075	0.0189	0.0917
Echinococcus granulosus	tfiia large subunit	0.0106	0.0435	0.3116
Brugia malayi	RE15519p	0.0075	0.0189	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Echinococcus multilocularis	tfiia large subunit	0.0106	0.0435	0.3116
Schistosoma mansoni	alpha-glucosidase	0.0144	0.0733	0.5376
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	neuropeptide receptor A26	0.0075	0.0189	0.1245
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0106	0.0432	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	amine GPCR	0.0075	0.0189	0.1245
Echinococcus multilocularis	neuropeptide receptor	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Brugia malayi	G protein-coupled receptor F59B2.13	0.0075	0.0189	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0075	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.0432	0.2494
Echinococcus multilocularis	g-protein coupled receptor	0.0075	0.0189	0.1245
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0106	0.0432	0.2494
Echinococcus multilocularis	neuropeptides capa receptor	0.0075	0.0189	0.1245
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0221	0.1342	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	sex peptide receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0221	0.1342	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0075	0.0189	0.0917
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	dro:myosuppressin receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0122	0.0556	0.4036
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0075	0.0189	0.1245
Brugia malayi	Melibiase family protein	0.018	0.1016	0.4935
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0075	0.0189	0.0189
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0221	0.1342	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0075	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus granulosus	enteropeptidase	0.0069	0.0136	0.0843
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus granulosus	biogenic amine 5HT receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.1317	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0075	0.0189	0.1245
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0124	0.057	0.3341
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0124	0.057	0.3341
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0106	0.0432	0.3093
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1298	0.626
Onchocerca volvulus		0.0075	0.0189	0.1559
Brugia malayi	hypothetical protein	0.0075	0.0189	0.0917
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0075	0.0189	0.1245
Echinococcus granulosus	neuropeptides capa receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	tissue type plasminogen activator	0.0062	0.0087	0.0474
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Loa Loa (eye worm)	TYRA-2 protein	0.0075	0.0189	0.0189
Brugia malayi	Serotonin receptor	0.0075	0.0189	0.0917
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0069	0.0136	0.0843
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0106	0.0432	0.0432
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0075	0.0189	0.1245
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0075	0.0189	0.1559
Onchocerca volvulus		0.0076	0.0194	0.1602
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus granulosus	neuropeptide s receptor	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2059	1
Schistosoma mansoni	hypothetical protein	0.0072	0.0164	0.1054
Brugia malayi	G-protein coupled receptor	0.0075	0.0189	0.0917
Echinococcus granulosus	serotonin receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	tfiia large subunit	0.0106	0.0435	0.3116
Leishmania major	peptidylprolyl isomerase-like protein	0.0106	0.0432	0.2494
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus multilocularis	serotonin receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	neuropeptide F receptor	0.0075	0.0189	0.0189
Echinococcus multilocularis	neuropeptide Y receptor	0.0075	0.0189	0.1245
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0106	0.0432	0.2099
Leishmania major	fk506-binding protein 1-like protein	0.0106	0.0432	0.2494
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0055	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.018	0.1016	0.4873
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.1211	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Echinococcus multilocularis	tissue type plasminogen activator	0.0062	0.0087	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	fk506 binding protein	0.0106	0.0432	0.3093
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1211	0.5832
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0194	0.0194
Echinococcus granulosus	hypothetical protein	0.0075	0.0189	0.1245
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0075	0.0189	0.1245
Onchocerca volvulus		0.0075	0.0189	0.1559
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0106	0.0432	1
Echinococcus multilocularis	fmrfamide receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0087	0.0087
Schistosoma mansoni	neuropeptide f receptor 76f	0.0075	0.0189	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0189	0.1245
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0138	0.0681	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	biogenic amine 5HT receptor	0.0075	0.0189	0.1245
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0178	0.1003	0.1003
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0075	0.0189	0.1245
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1298	0.626
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0075	0.0189	0.1245
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0075	0.0189	0.1245
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0106	0.0432	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0075	0.0189	0.1245
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0106	0.0432	0.2494
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0075	0.0189	0.1245
Echinococcus granulosus	orexin receptor type 2	0.0075	0.0189	0.1245
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0189	0.1245
Schistosoma mansoni	hypothetical protein	0.0075	0.0189	0.1245
Echinococcus multilocularis	glycoprotein Antigen 5	0.0069	0.0136	0.0843
Onchocerca volvulus		0.0053	0.0016	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0189	0.0189
Echinococcus multilocularis	Mastin	0.0069	0.0136	0.0843
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0106	0.0432	0.2002
Loa Loa (eye worm)	transcription factor IIA	0.0106	0.0435	0.0435
Echinococcus granulosus	neuropeptide FF receptor 2	0.0075	0.0189	0.1245
Brugia malayi	G-protein coupled receptor	0.0075	0.0189	0.0917
Brugia malayi	GnHR receptor homolog	0.0075	0.0189	0.0917
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0075	0.0189	0.1245
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0075	0.0189	0.1245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0189	0.1245
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0075	0.0189	0.1245

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 9990 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference
EC50 (binding)	= 9990 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference
IC50 (binding)	= 41700 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference
IC50 (binding)	= 41700 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference
Ki (binding)	= 17280 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference
Ki (binding)	= 17280 nM	BindingDB_Patents: Enzyme Assay. To 2.5 µl of supernatant (in 96-well plates) was added 17.5 µl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 µl of 4-methyl umbelliferone (4-MU)-labeled substrate, ß-glucopyranoside, or a labeled negative controls (a-glucopyranoside or a-galacatopyranoside). Plates were incubated at 37° for 1 hour, followed by the addition of 70 µl stop buffer (0.4 M glycine-NaOH, pH 10.6). Activity of GCase was determined by measuring the emission at 460 nm by exciting at 355 nm using a 1 second read time per well (Victor2 multilabel counter-Wallac) Enzyme activity was normalized to the amount in µl of lysate added, and enzyme activity per µl of lysate was estimated.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3897879

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2243205