Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2965 | 0.8217 | 0.8211 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1527 | 0.4177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0233 | 0.0196 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0058 | 0.0048 | 0.0183 |
Toxoplasma gondii | hypothetical protein | 0.1772 | 0.4866 | 0.5 |
Entamoeba histolytica | ankyrin, putative | 0.0071 | 0.0085 | 0.0213 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1772 | 0.4866 | 0.4841 |
Schistosoma mansoni | hypothetical protein | 0.1772 | 0.4866 | 0.4841 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0913 | 0.2451 | 0.928 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0058 | 0.0048 | 0.0048 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0233 | 0.3242 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0048 | 0.0115 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1772 | 0.4866 | 0.4841 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0233 | 0.0185 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3599 | 1 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1459 | 0.3987 | 0.3987 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1459 | 0.3987 | 0.9545 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0071 | 0.0085 | 0.0322 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.0475 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.1772 | 0.4866 | 0.4847 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1772 | 0.4866 | 0.4841 |
Loa Loa (eye worm) | hypothetical protein | 0.1772 | 0.4866 | 0.4847 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0981 | 0.2641 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.0121 | 0.0073 |
Echinococcus multilocularis | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Echinococcus granulosus | dynactin 5 p25 | 0.0071 | 0.0085 | 0.0037 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0696 | 0.184 | 0.1801 |
Echinococcus multilocularis | carbonic anhydrase II | 0.3599 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0696 | 0.184 | 0.1801 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1772 | 0.4866 | 0.4841 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.0121 | 0.0073 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1772 | 0.4866 | 0.4841 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.0121 | 0.0073 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.0121 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0233 | 0.0196 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1459 | 0.3987 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3599 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1772 | 0.4866 | 0.4841 |
Onchocerca volvulus | 0.0206 | 0.0464 | 0.8072 | |
Entamoeba histolytica | acetyltransferase, putative | 0.0071 | 0.0085 | 0.0213 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.0557 | 0.1169 |
Echinococcus granulosus | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0238 | 0.0554 | 0.1219 |
Echinococcus multilocularis | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Leishmania major | carbonic anhydrase-like protein | 0.3599 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.0475 | 0.044 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1772 | 0.4866 | 0.4841 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.3599 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Mycobacterium ulcerans | transferase | 0.0068 | 0.0077 | 0.0185 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1772 | 0.4866 | 0.4847 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1459 | 0.3987 | 1 |
Onchocerca volvulus | 0.0239 | 0.0557 | 1 | |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0071 | 0.0085 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0233 | 0.3242 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1772 | 0.4866 | 0.4841 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.3599 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1527 | 0.4177 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0048 | 0.0115 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0784 | 0.209 | 0.7912 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1527 | 0.4177 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3599 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0696 | 0.184 | 0.1801 |
Schistosoma mansoni | carbonic anhydrase | 0.1459 | 0.3987 | 0.3958 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0121 | 0.0084 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0238 | 0.0554 | 0.2097 |
Schistosoma mansoni | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Echinococcus granulosus | carbonic anhydrase II | 0.3599 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1772 | 0.4866 | 0.4841 |
Plasmodium falciparum | carbonic anhydrase | 0.1772 | 0.4866 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.3599 | 1 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0206 | 0.0464 | 0.8072 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.3599 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3599 | 1 | 1 |
Onchocerca volvulus | 0.0084 | 0.0121 | 0.0916 | |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0071 | 0.0085 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.64 uM | Tested for the displacement [3H]-PIA from Adenosine A1 receptor in rat brain membrane | ChEMBL. | 8558508 |
Ki (binding) | = 106 uM | Displacement [3H]-CGS-21,680 from Adenosine A2A receptor in rat striatal membrane. | ChEMBL. | 8558508 |
Selectivity (binding) | = 29.1 | Selectivity for adenosine A2a and A1 receptors | ChEMBL. | 8558508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.