Detailed information for compound 2252843

Basic information

Technical information
  • TDR Targets ID: 2252843
  • Name: [(1R,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden- 1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hy droxycyclopentyl]methyl sulfamate
  • MW: 443.163 | Formula: C21H25N5O4S
  • H donors: 3 H acceptors: 5 LogP: 1.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 0
  • SMILES: O[C@H]1C[C@@H](C[C@@H]1COS(=O)(=O)N)n1ccc2c1ncnc2N[C@H]1CCc2c1cccc2
  • InChi: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15-,18+,19+/m1/s1
  • InChiKey: MPUQHZXIXSTTDU-LTDCPUDJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(1R,2S,4R)-2-hydroxy-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentyl]methyl sulfamate
  • sulfamic acid [(1R,2S,4R)-2-hydroxy-4-[4-[[(1S)-1-indanyl]amino]-7-pyrrolo[2,3-d]pyrimidinyl]cyclopentyl]methyl ester
  • sulfamic acid [(1R,2S,4R)-2-hydroxy-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentyl]methyl ester
  • [(1R,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxy-cyclopentyl]methyl sulfamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin-like modifier activating enzyme 3 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei NEDD8 activating enzyme subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_128095 All targets in OG5_128095
Plasmodium vivax ubiquitin-activating enzyme E1C, putative Get druggable targets OG5_128095 All targets in OG5_128095
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit Get druggable targets OG5_128095 All targets in OG5_128095
Schistosoma mansoni ubiquitin-activating enzyme E1C Get druggable targets OG5_128095 All targets in OG5_128095
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 Get druggable targets OG5_128095 All targets in OG5_128095
Schistosoma japonicum ko:K06917 tRNA 2-selenouridine synthase, putative Get druggable targets OG5_128095 All targets in OG5_128095
Leishmania donovani ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Trypanosoma cruzi ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Plasmodium berghei NEDD8-activating enzyme E1 catalytic subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Plasmodium knowlesi NEDD8-activating enzyme E1 catalytic subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_128095 All targets in OG5_128095
Candida albicans Ubiquitin activating enzyme Get druggable targets OG5_128095 All targets in OG5_128095
Trypanosoma cruzi ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Schistosoma japonicum NEDD8-activating enzyme E1 catalytic subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Leishmania major ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Leishmania mexicana ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Schistosoma japonicum NEDD8-activating enzyme E1 catalytic subunit, putative Get druggable targets OG5_128095 All targets in OG5_128095
Theileria parva hypothetical protein, conserved Get druggable targets OG5_128095 All targets in OG5_128095
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit Get druggable targets OG5_128095 All targets in OG5_128095
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit Get druggable targets OG5_128095 All targets in OG5_128095
Neospora caninum ubiquitin-activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Cryptosporidium hominis ubiquitin-activating enzyme Get druggable targets OG5_128095 All targets in OG5_128095
Candida albicans Ubiquitin activating enzyme Get druggable targets OG5_128095 All targets in OG5_128095
Schistosoma japonicum ko:K10686 ubiquitin-activating enzyme E1 C, putative Get druggable targets OG5_128095 All targets in OG5_128095
Brugia malayi Ectopic membrane ruffles in embryo protein 1 Get druggable targets OG5_128095 All targets in OG5_128095
Cryptosporidium parvum Uba3p like ubiquitin activating enzyme E1 Get druggable targets OG5_128095 All targets in OG5_128095
Leishmania infantum ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Leishmania braziliensis ubiquitin activating enzyme, putative Get druggable targets OG5_128095 All targets in OG5_128095
Babesia bovis ThiF family domain containing protein Get druggable targets OG5_128095 All targets in OG5_128095
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_128095 All targets in OG5_128095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.023 0.0685
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0062 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0256
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.023 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.023 0.0482
Brugia malayi neuropeptide F receptor 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Onchocerca volvulus 0.0025 0.023 0.0357
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.023 0.0357
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0112 0.0234
Onchocerca volvulus 0.0025 0.023 0.0357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0629 0.1873
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0122 0.0129
Schistosoma mansoni myosin xvIII 0.0025 0.023 0.023
Onchocerca volvulus 0.0039 0.0629 0.1203
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0629 0.1203
Schistosoma mansoni opsin-like receptor 0.0025 0.023 0.023
Echinococcus multilocularis serotonin receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Onchocerca volvulus 0.0025 0.023 0.0357
Schistosoma mansoni neuropeptide receptor 0.0025 0.023 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.023 0.0685
Onchocerca volvulus 0.0025 0.023 0.0357
Leishmania major casein kinase, putative 0.0046 0.0816 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0629 0.1873
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0062 0.0184
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0112 0.5
Onchocerca volvulus 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0326 0.0683
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni adenoreceptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.023 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0629 0.1317
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0816 0.7321
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0629 0.1317
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.023 0.023
Brugia malayi neuropeptide F receptor 0.0025 0.023 0.0357
Schistosoma mansoni hypothetical protein 0.0025 0.023 0.023
Echinococcus granulosus neuropeptide s receptor 0.0025 0.023 0.0685
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.023 0.0685
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0629 0.1203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0629 0.1873
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.023 0.0685
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.023 0.023
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0629 0.1873
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0629 0.1873
Echinococcus multilocularis casein kinase I delta 0.0046 0.0816 0.2432
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0629 0.1203
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0077 0.1662 0.1662
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0629 0.1873
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0629 0.1203
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0133 0.3183 0.6663
Toxoplasma gondii casein kinase I 0.0046 0.0816 0.4546
Echinococcus multilocularis casein kinase I delta 0.0046 0.0816 0.2432
Brugia malayi Melatonin receptor type 1A 0.0025 0.023 0.0357
Schistosoma mansoni hypothetical protein 0.0025 0.023 0.023
Schistosoma mansoni zinc finger protein 0.0019 0.0062 0.0062
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0629 0.0629
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0629 0.1873
Brugia malayi GnHR receptor homolog 0.0025 0.023 0.0357
Echinococcus granulosus casein kinase I delta 0.0046 0.0816 0.2432
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0024 0.0207 0.135
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.023 0.0685
Echinococcus multilocularis neuropeptide receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni biogenic amine receptor 0.0025 0.023 0.023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.023 0.0685
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.023 0.0357
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0062 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi hypothetical protein 0.0021 0.0122 0.0129
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.023 0.0357
Leishmania major ubiquitin activating enzyme, putative 0.0024 0.0207 0.135
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0629 0.0629
Schistosoma mansoni coup transcription factor 0.0039 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi follicle stimulating hormone receptor 0.0025 0.023 0.0357
Onchocerca volvulus 0.0045 0.0791 0.1547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0629 0.1317
Entamoeba histolytica casein kinase 1, putative 0.0046 0.0816 0.4546
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0122 0.0122
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0341 0.0592
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.023 0.0685
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.023 0.0357
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.023 0.0685
Schistosoma mansoni histamine h1 receptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Onchocerca volvulus Huntingtin homolog 0.0133 0.3183 0.662
Schistosoma mansoni amine GPCR 0.0025 0.023 0.023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0341 0.0713
Onchocerca volvulus 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0256
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi G-protein coupled receptor 0.0025 0.023 0.0357
Onchocerca volvulus 0.0025 0.023 0.0357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0629 0.1203
Echinococcus granulosus g protein coupled receptor 0.0025 0.023 0.0685
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.3777 0.3777
Schistosoma mansoni ap endonuclease 0.002 0.0112 0.0112
Brugia malayi Serotonin receptor 0.0025 0.023 0.0357
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0629 0.1873
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Onchocerca volvulus 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0062 0.0184
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.023 0.0685
Echinococcus granulosus neuropeptide receptor 0.0025 0.023 0.0685
Brugia malayi nuclear receptor RXR 0.0021 0.0122 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0046 0.0816 0.1709
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.023 0.0685
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.023 0.0357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0112 0.0107
Brugia malayi Dopamine receptor protein 2 0.0025 0.023 0.0357
Echinococcus granulosus casein kinase I alpha 0.0046 0.0816 0.2432
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.023 0.023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.023 0.0685
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Brugia malayi AKH receptor 0.0025 0.023 0.0357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.023 0.0685
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.023 0.0685
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis casein kinase i 0.0046 0.0816 0.2432
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus granulosus lamin dm0 0.0029 0.0341 0.1015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.023 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0629 0.1203
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.023 0.023
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0077 0.1662 0.3394
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0629 0.1873
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0629 0.0629
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0062 0.0184
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0077 0.1662 0.3479
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0629 0.1873
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.023 0.023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.023 0.0685
Echinococcus granulosus casein kinase I delta 0.0046 0.0816 0.2432
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Onchocerca volvulus 0.0025 0.023 0.0357
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0122 0.0365
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.023 0.023
Echinococcus granulosus g-protein coupled receptor 0.0025 0.023 0.0685
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.023 0.0685
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.023 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0629 0.1203
Echinococcus granulosus casein kinase I alpha 0.0046 0.0816 0.2432
Schistosoma mansoni nuclear receptor 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0112 0.0333
Plasmodium falciparum casein kinase 1 0.0046 0.0816 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0062 0.0184
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0112 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0155 0.3777 0.7881
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Brugia malayi Dopamine receptor protein 1 0.0025 0.023 0.0357
Echinococcus multilocularis fmrfamide receptor 0.0025 0.023 0.0685
Echinococcus granulosus serotonin receptor 0.0025 0.023 0.0685
Schistosoma mansoni hypothetical protein 0.0025 0.023 0.023
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0155 0.3777 0.7908
Brugia malayi Serotonin receptor 0.0025 0.023 0.0357
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0341 0.0713
Brugia malayi Dopamine receptor 0.0025 0.023 0.0357
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.014 0.3357 1
Brugia malayi nuclear hormone receptor 0.0039 0.0629 0.1203
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0112 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.023 0.0685
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.023 0.0685
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0122 0.0365
Schistosoma mansoni intermediate filament proteins 0.0029 0.0341 0.0341
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.023 0.0685
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.023 0.0685
Schistosoma mansoni lamin 0.0029 0.0341 0.0341
Schistosoma mansoni biogenic amine receptor 0.0025 0.023 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0629 0.1873
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.023 0.0685
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.023 0.0357
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni ap endonuclease 0.002 0.0112 0.0112
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0062 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.023 0.0685
Schistosoma mansoni nuclear receptor 0.0019 0.0062 0.0062
Entamoeba histolytica casein kinase, putative 0.0046 0.0816 0.4546
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.023 0.0685
Trypanosoma cruzi casein kinase, putative 0.0046 0.0816 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Onchocerca volvulus 0.0025 0.023 0.0357
Schistosoma mansoni lamin 0.0029 0.0341 0.0341
Echinococcus granulosus casein kinase i 0.0046 0.0816 0.2432
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0816 0.7321
Brugia malayi RE15519p 0.0025 0.023 0.0357
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0062 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus granulosus g protein coupled receptor 0.0025 0.023 0.0685
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0062 0.0062
Brugia malayi intermediate filament protein 0.0029 0.0341 0.0592
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0629 0.1203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0816 0.2432
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.023 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni biogenic amine receptor 0.0025 0.023 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0133 0.3183 0.6663
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis sex peptide receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Onchocerca volvulus 0.0046 0.0816 0.1601
Schistosoma mansoni amine GPCR 0.0025 0.023 0.023
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Onchocerca volvulus 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni opsin-like receptor 0.0025 0.023 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0629 0.1203
Echinococcus multilocularis lamin 0.0029 0.0341 0.1015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0112 0.5
Onchocerca volvulus 0.0029 0.0341 0.0592
Schistosoma mansoni amine GPCR 0.0025 0.023 0.023
Onchocerca volvulus Huntingtin homolog 0.0133 0.3183 0.662
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0062 0.0062
Trypanosoma cruzi casein kinase, putative 0.0046 0.0816 1
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.023 0.0685
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0629 0.1873
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0077 0.1662 0.4949
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0629 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0629 0.1203
Trypanosoma brucei casein kinase I, isoform 2 0.0046 0.0816 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0046 0.0816 0.1709
Echinococcus multilocularis g protein coupled receptor 0.0025 0.023 0.0685
Echinococcus granulosus orexin receptor type 2 0.0025 0.023 0.0685
Echinococcus multilocularis somatostatin receptor 0.0025 0.023 0.0685
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Brugia malayi hypothetical protein 0.0021 0.0122 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi hypothetical protein 0.0133 0.3183 0.662
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0025 0.023 0.023
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.023 0.0685
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.014 0.3357 0.7029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.023 0.0357
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0024 0.0207 0.135
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0256
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0256
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0629 0.1873
Onchocerca volvulus Bile acid receptor homolog 0.0192 0.4776 1
Trypanosoma cruzi casein kinase, putative 0.0046 0.0816 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.023 0.023
Schistosoma mansoni neuropeptide receptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0062 0.0184
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0024 0.0207 0.135
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0629 0.0629
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0062 0.0184
Echinococcus granulosus hypothetical protein 0.0025 0.023 0.0685
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.023 0.0685
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0062 0.0184
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.023 0.0685
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0629 0.0629
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0629 0.0629
Echinococcus multilocularis fmrfamide receptor 0.0025 0.023 0.0685
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0816 0.2432
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0122 0.0122
Brugia malayi ORL1-like opioid receptor 0.0025 0.023 0.0357
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0122 0.0129
Echinococcus multilocularis G protein coupled receptor kinase 6 0.014 0.3357 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0046 0.0816 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0629 0.1203
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0629 0.1873
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0629 0.1203
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0192 0.4776 1
Plasmodium vivax casein kinase 1, putative 0.0046 0.0816 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.023 0.0685
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0046 0.0816 0.1709
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.023 0.023
Schistosoma mansoni neuropeptide receptor 0.0025 0.023 0.023
Echinococcus granulosus allatostatin A receptor 0.0025 0.023 0.0685
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0816 0.2432
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.023 0.023
Trypanosoma cruzi casein kinase, putative 0.0046 0.0816 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.023 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.023 0.0685
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.023 0.0482
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.023 0.0357
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.023 0.0482
Echinococcus multilocularis orexin receptor type 2 0.0025 0.023 0.0685
Brugia malayi G protein-coupled receptor 0.0025 0.023 0.0357
Schistosoma mansoni amine GPCR 0.0025 0.023 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0629 0.1873
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus granulosus g protein coupled receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0122 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0629 0.1317
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0062 0.0184
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Echinococcus granulosus lamin 0.0029 0.0341 0.1015
Schistosoma mansoni opsin-like receptor 0.0025 0.023 0.023
Schistosoma mansoni protein kinase 0.0046 0.0816 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0062 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.023 0.0482
Schistosoma mansoni amine GPCR 0.0025 0.023 0.023
Giardia lamblia Kinase, CK1 Casein kinase 0.0046 0.0816 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.014 0.3357 0.699
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.023 0.023
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0629 0.1203
Onchocerca volvulus 0.0025 0.023 0.0357
Brugia malayi sulfakinin receptor protein 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.023 0.023
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Echinococcus multilocularis serotonin receptor 0.0025 0.023 0.0685
Brugia malayi nuclear receptor NHR-88 0.0039 0.0629 0.1203
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0062 0.0184
Brugia malayi putative neuropeptide receptor 0.0025 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis allatostatin A receptor 0.0025 0.023 0.0685
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.023 0.0685
Echinococcus granulosus intermediate filament protein 0.0029 0.0341 0.1015
Echinococcus multilocularis lamin dm0 0.0029 0.0341 0.1015
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus multilocularis neuropeptide receptor 0.0025 0.023 0.0685
Echinococcus multilocularis musashi 0.0029 0.0341 0.1015
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0056 0.1074 1
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.023 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0629 0.1317
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.023 0.0685
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.023 0.023
Brugia malayi steroid hormone receptor 0.0039 0.0629 0.1203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.023 0.0685
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0816 0.7321
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0629 0.1203
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0024 0.0207 0.135
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0629 0.1203
Onchocerca volvulus 0.0025 0.023 0.0357
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0629 0.0629
Brugia malayi ecdysteroid receptor 0.0192 0.4776 1
Onchocerca volvulus 0.0025 0.023 0.0357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.023 0.0685
Echinococcus granulosus sex peptide receptor 0.0025 0.023 0.0685
Trypanosoma cruzi casein kinase, putative 0.0046 0.0816 1
Brugia malayi larval opioid receptor 0.0025 0.023 0.0357
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0024 0.0207 0.135
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.023 0.0685
Echinococcus granulosus neuropeptide receptor 0.0025 0.023 0.0685
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.023 0.0685
Onchocerca volvulus 0.0029 0.0341 0.0592
Brugia malayi casein kinase I 0.0046 0.0816 0.1601
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0629 0.1203
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0077 0.1662 1
Brugia malayi G-protein coupled receptor 0.0025 0.023 0.0357
Schistosoma mansoni neuropeptide receptor 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.023 0.023
Echinococcus granulosus casein kinase I alpha 0.0046 0.0816 0.2432
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Onchocerca volvulus 0.0025 0.023 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0629 0.1203
Onchocerca volvulus 0.0025 0.023 0.0357
Echinococcus multilocularis g protein coupled receptor 0.0025 0.023 0.0685
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.023 0.0685
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.023 0.023
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0629 0.0629
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0629 0.1873
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.014 0.3357 0.7029
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0077 0.1662 0.4949
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0629 0.0629
Echinococcus multilocularis g protein coupled receptor 0.0025 0.023 0.0685
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0629 0.1873
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0062 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0112 0.0333
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.023 0.0685
Echinococcus granulosus fmrfamide receptor 0.0025 0.023 0.0685
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0045 0.0791 0.9642
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0077 0.1662 1
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0062 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.023 0.023
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0629 0.0629
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.023 0.0685
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.023 0.0685
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.023 0.0482
Brugia malayi hypothetical protein 0.0025 0.023 0.0357
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0629 0.0629
Onchocerca volvulus 0.0025 0.023 0.0357
Brugia malayi casein kinase 1, delta 0.0046 0.0816 0.1601
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.1317
Loa Loa (eye worm) hypothetical protein 0.0029 0.0341 0.0713
Loa Loa (eye worm) DR-78 0.0019 0.0062 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0129
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.023 0.0685
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0024 0.0207 0.0988
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.023 0.0685
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0629 0.1873
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Echinococcus granulosus somatostatin receptor 0.0025 0.023 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.0482
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.023 0.0482

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) <= 0.1 uM Inhibition of recombinant human untagged NAEalpha/N-terminal His-tagged NAEbeta expressed in Bac-to-Bac expression system using FLAG-tagged NEDD8 as substrate after 90 mins in presence of GST-tagged Ubc12 by HTRF assay PATENT. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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