Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.4 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 773 aa | 20.7 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 33.7 % | |
Schistosoma japonicum | Endothelin-converting enzyme 2, putative | Neprilysin | 750 aa | 787 aa | 21.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0274 | 0.3131 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0274 | 0.3131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0274 | 0.3131 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0274 | 0.3131 | 0.2519 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.0817 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0817 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0817 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0817 | 0.0448 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.0817 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.0817 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.0817 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0274 | 0.3131 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0274 | 0.3131 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.3131 | 0.2854 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0416 | 0.003 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.0817 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 nM | Inhibitory activity against angiotensin I converting enzyme | ChEMBL. | 8632427 |
IC50 (binding) | = 1.6 nM | Inhibitory activity against angiotensin I converting enzyme | ChEMBL. | 8632427 |
IC50 (binding) | = 46 nM | Inhibitory activity was tested against neutral endopeptidase | ChEMBL. | 8632427 |
IC50 (binding) | = 46 nM | Inhibitory activity was tested against neutral endopeptidase | ChEMBL. | 8632427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.