Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Mycobacterium leprae | probable zinc metalloprotease | 0.2233 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.165 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.165 | 0.4828 | 0.4828 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.2233 | 1 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.2233 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.2233 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.2233 | 1 | 0.5 |
Onchocerca volvulus | 0.1106 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.165 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.165 | 0.4828 | 0.4828 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.2233 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.2233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.165 | 0.4828 | 0.4828 |
Toxoplasma gondii | peptidase family M13 protein | 0.2233 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1689 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.165 | 0.4828 | 0.4828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 50 nM | Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes 3[H]spiperone, a dopamine antagonist | ChEMBL. | 1359142 |
IC50 (functional) | = 50 nM | Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes 3[H]spiperone, a dopamine antagonist | ChEMBL. | 1359142 |
Ki (functional) | = 12 nM | Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes [3H]ADTN, a dopamine agonist | ChEMBL. | 1359142 |
Ki (functional) | = 12 nM | Evaluated for its ability to displace tritiated receptor ligand in rat striatal membranes [3H]ADTN, a dopamine agonist | ChEMBL. | 1359142 |
Turns/first hour (functional) | ~ 250 | Evaluated in vivo for its ability to induce contralateral rotational behavior in rats with unilateral , 6-hydroxy DA induced lesions of the substantia nigra at 3 mg/kg dosage orally | ChEMBL. | 1359142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.