TDR Targets

Basic information

Technical information

TDR Targets ID: 226355
Name: ethyl 2-(1-oxo-4-pyridin-3-ylphthalazin-2-yl) acetate
MW: 309.319 | Formula: C17H15N3O3
H donors: 0 H acceptors: 3 LogP: 2.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Cn1nc(c2cccnc2)c2c(c1=O)cccc2
InChi: 1S/C17H15N3O3/c1-2-23-15(21)11-20-17(22)14-8-4-3-7-13(14)16(19-20)12-6-5-9-18-10-12/h3-10H,2,11H2,1H3
InChiKey: JAVDBPTVTYBYAX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[1-oxo-4-(3-pyridyl)phthalazin-2-yl]acetate
2-[1-oxo-4-(3-pyridyl)-2-phthalazinyl]acetic acid ethyl ester
ethyl 2-(1-oxo-4-pyridin-3-yl-phthalazin-2-yl)ethanoate
2-[1-keto-4-(3-pyridyl)phthalazin-2-yl]acetic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0051	0.0774	0.0774
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0051	0.0774	0.0774
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0139	0.3312	0.3312
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.007	0.1326	0.1326
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0139	0.3312	0.3312
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0803	0.3499
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.007	0.1326	0.578
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.013	0.013
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0091	0.1923	0.226
Plasmodium falciparum	phd finger protein, putative	0.0029	0.013	0.1678
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0774	0.0774
Leishmania major	hypothetical protein, conserved	0.0051	0.0774	0.3373
Brugia malayi	jmjC domain containing protein	0.0035	0.0308	0.0362
Echinococcus granulosus	death domain containing protein	0.0091	0.1923	0.1923
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.2058	0.2058
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.005	0.0735	0.0735
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0051	0.0774	0.3373
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0308	0.0308
Giardia lamblia	PHD finger protein 15	0.0029	0.013	0.013
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0051	0.0774	0.091
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0051	0.0774	0.3373
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0318	0.8508	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Leishmania major	hypothetical protein, conserved	0.0051	0.0774	0.3373
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0051	0.0774	0.3373
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0085	0.1742	0.7593
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0051	0.0774	0.0774
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0104	0.2294	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1326	0.1326
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.007	0.1326	0.578
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0051	0.0774	0.0774
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0139	0.3312	0.3312
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Brugia malayi	PHD-finger family protein	0.0029	0.013	0.0153
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Loa Loa (eye worm)	hypothetical protein	0.037	1	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Brugia malayi	Bromodomain containing protein	0.0029	0.013	0.0153
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0462	0.0462
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0051	0.0774	0.3373
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0051	0.0774	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0774	0.3373
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.007	0.1326	0.1326
Onchocerca volvulus	Netrin receptor homolog	0.0091	0.1923	1
Brugia malayi	jmjC domain containing protein	0.0096	0.2058	0.2419
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0104	0.2294	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.013	0.013
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus multilocularis	Ankyrin	0.0091	0.1923	0.1923
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.013	0.013
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0803	0.3499
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.007	0.1326	0.578
Toxoplasma gondii	hypothetical protein	0.0052	0.0803	0.0803
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2294	1
Trypanosoma brucei	hypothetical protein, conserved	0.0051	0.0774	0.3373
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.0051	0.0774	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Brugia malayi	Uncoordinated protein 44	0.0091	0.1923	0.226
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0085	0.1742	0.7593
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0308	0.0308
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0051	0.0774	0.3373
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0051	0.0774	0.0774
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0051	0.0774	0.3373
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.2058	0.2058
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0091	0.1923	0.1923
Plasmodium vivax	phosphodiesterase gamma, putative	0.0051	0.0774	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0774	0.3373
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0104	0.2294	0.2294
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0139	0.3312	0.3312
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Entamoeba histolytica	tubulin family protein	0.0025	0	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Giardia lamblia	Hypothetical protein	0.0051	0.0774	0.0774
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0774	0.0774
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0051	0.0774	0.0774
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0085	0.1742	0.7593
Brugia malayi	Death domain containing protein	0.0091	0.1923	0.226
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.013	0.013
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0051	0.0774	0.091
Loa Loa (eye worm)	PDE1B protein	0.0051	0.0774	0.0774
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.007	0.1326	0.1326
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Brugia malayi	Protein kinase domain containing protein	0.0091	0.1923	0.226
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0308	0.0308
Echinococcus granulosus	peregrin	0.0029	0.013	0.013
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0091	0.1923	0.1923
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0104	0.2294	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0104	0.2294	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1923	0.1923
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0104	0.2294	0.2294
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0051	0.0774	0.0774
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.037	1	1
Echinococcus granulosus	netrin receptor unc 5	0.0091	0.1923	0.1923
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0051	0.0774	0.3373
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0091	0.1923	0.1923
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.037	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0051	0.0774	0.3373
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0462	0.0462
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Schistosoma mansoni	hypothetical protein	0.0091	0.1923	0.1923
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Echinococcus granulosus	Ankyrin	0.0091	0.1923	0.1923
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0091	0.1923	0.1923
Schistosoma mansoni	netrin receptor unc5	0.0091	0.1923	0.1923
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.013	0.1678
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0104	0.2294	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0051	0.0774	0.0774
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0029	0.013	0.013
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0051	0.0774	1
Echinococcus multilocularis	peregrin	0.0029	0.013	0.013
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0308	0.0308
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0051	0.0774	0.091
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0803	0.3499
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.1488	0.1488
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0104	0.2294	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0318	0.8508	0.8508
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0051	0.0774	1
Entamoeba histolytica	tubulin family protein	0.0025	0	0.5
Giardia lamblia	hypothetical protein	0.0051	0.0774	0.0774
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0104	0.2294	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.007	0.1326	0.1559
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.037	1	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0051	0.0774	0.0774
Schistosoma mansoni	ankyrin 23/unc44	0.0091	0.1923	0.1923
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.013	0.013
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0051	0.0774	0.0774
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.007	0.1326	0.1559
Echinococcus multilocularis	netrin receptor unc 5	0.0091	0.1923	0.1923
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0051	0.0774	0.0774
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0104	0.2294	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.037	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.1032	0.1032
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0104	0.2294	0.2294
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0104	0.2294	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.037	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1923	0.1923
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0318	0.8508	0.8508
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.037	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0774	0.3373
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0051	0.0774	0.0774
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0051	0.0774	0.3373
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0318	0.8508	0.8508
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0051	0.0774	0.091
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0051	0.0774	0.3373
Schistosoma mansoni	tumor necrosis factor receptor related	0.0139	0.3312	0.3312
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0051	0.0774	0.0774

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log IC50 (functional)	= 4.36	In vitro bronchodilatory activity in guinea pig isolated tracheal strips	ChEMBL.	8258828
Inhibition (functional)	= 0 %	Tested ex vivo against TXA2 production in rat serum at 1 hr after peroral dose of 30 mg/kg and anesthetized with ether	ChEMBL.	8258828
Inhibition (functional)	= 0 %	Tested ex vivo against TXA2 production in rat serum at 1 hr after peroral dose of 30 mg/kg and anesthetized with ether	ChEMBL.	8258828
Inhibition (binding)	= 28 %	Tested in vitro against rabbit thromboxane A2 synthetase (TXA2) at 1 microM	ChEMBL.	8258828
Inhibition (binding)	= 28 %	Tested in vitro against rabbit thromboxane A2 synthetase (TXA2) at 1 microM	ChEMBL.	8258828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL131029
PubChem: 10403061

Bibliographic References

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Detailed information for compound 226355