Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6042 | 0.599 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.206 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.009 | 0.206 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.5824 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.009 | 0.206 | 0.1622 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0291 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0163 | 0.4961 | 0.4683 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0275 | 0.9377 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0275 | 0.9377 | 1 |
Brugia malayi | Peroxidasin | 0.0275 | 0.9377 | 0.9216 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0291 | 1 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0163 | 0.4961 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.009 | 0.2078 | 0.0023 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.01 | 0.248 | 0.053 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.9271 | 0.9142 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.9271 | 0.9873 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.009 | 0.206 | 0.206 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0163 | 0.4961 | 0.4961 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.9377 | 0.9216 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Echinococcus multilocularis | peroxidasin | 0.0275 | 0.9377 | 0.9377 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0275 | 0.9377 | 0.9216 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0275 | 0.9377 | 0.9343 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0291 | 1 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.9271 | 0.9082 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1504 | 0.1504 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0078 | 0.1582 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.9271 | 0.9873 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0163 | 0.4961 | 0.4069 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0291 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1504 | 0.1036 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.9271 | 0.9031 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3423 | 0.2842 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.1 M | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
IC50 (functional) | = 3.5 M | Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
Inhibition (functional) | = 44.9 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 3*10e-7 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 49 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 3*10e-7 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 84.2 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 1*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 87.8 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 1*10e-6 M concentration. | ChEMBL. | 1560434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.