Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0312 | 0.5 | 0.5 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0312 | 0.5 | 0.5 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0312 | 0.5 | 0.5 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0312 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-oxotremorine-M binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 5 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-oxotremorine-M binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 37 nM | In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 37 nM | In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 81 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-Quinuclidinyl benzilate binding on rat brain homogenate | ChEMBL. | 7990109 |
Ki (binding) | = 81 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-Quinuclidinyl benzilate binding on rat brain homogenate | ChEMBL. | 7990109 |
Ki (binding) | = 220 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-quinuclidinyl benzilate binding on rat brain stem homogenate. | ChEMBL. | 7990109 |
Ki (binding) | = 220 nM | In vitro binding affinity for muscarinic receptor by displacing [3H]-quinuclidinyl benzilate binding on rat brain stem homogenate. | ChEMBL. | 7990109 |
Ratio (functional) | = 5.9 | Ratio of binding affinity at [3H]-Quinuclidinyl benzilate binding on rat brain stem homogenate to [3H]-Piperazine binding on rat brain homogenate | ChEMBL. | 7990109 |
Ratio (functional) | = 16 | Ratio of binding affinity at [3H]-Quinuclidinyl benzilate binding on rat brain homogenate to [3H]- Oxotremorine-M binding on rat brain homogenate | ChEMBL. | 7990109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.