Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0517 | 0.4787 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0517 | 0.4787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 0.5696 | 0.5628 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0965 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0965 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0517 | 0.4787 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0965 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0965 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0965 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0965 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0517 | 0.4787 | 0.2483 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0517 | 0.4787 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0517 | 0.4787 | 0.4787 |
Loa Loa (eye worm) | hypothetical protein | 0.0965 | 1 | 1 |
Onchocerca volvulus | 0.037 | 0.3065 | 0.3065 | |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0517 | 0.4787 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0517 | 0.4787 | 0.4705 |
Schistosoma mansoni | adenosine deaminase-related | 0.0965 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0517 | 0.4787 | 0.2483 |
Schistosoma mansoni | AMP deaminase | 0.0517 | 0.4787 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 0.5696 | 0.5628 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0965 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0517 | 0.4787 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0517 | 0.4787 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0965 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0965 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0965 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0965 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0483 | 0.0333 |
Onchocerca volvulus | 0.012 | 0.0155 | 0.0155 | |
Trypanosoma cruzi | AMP deaminase, putative | 0.0517 | 0.4787 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0965 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0965 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0517 | 0.4787 | 0.2483 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 0.5696 | 0.5628 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0517 | 0.4787 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0517 | 0.4787 | 0.4705 |
Echinococcus multilocularis | adenosine deaminase | 0.0965 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.3065 | 0.2956 |
Loa Loa (eye worm) | hypothetical protein | 0.0595 | 0.5696 | 0.5628 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0965 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0965 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0517 | 0.4787 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0965 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.0517 | 0.4787 | 0.2483 |
Trypanosoma brucei | AMP deaminase, putative | 0.0517 | 0.4787 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | In vitro inhibition of coagulation factor Xa. | ChEMBL. | 11063603 |
IC50 (binding) | = 0.24 uM | In vitro inhibition of coagulation factor Xa. | ChEMBL. | 11063603 |
IC50 (binding) | = 1.1 uM | In vitro inhibitory activity against trypsin | ChEMBL. | 11063603 |
IC50 (binding) | = 1.1 uM | In vitro inhibitory activity against trypsin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.2 uM | Inhibition of thrombin | ChEMBL. | 11063603 |
IC50 (binding) | = 2.2 uM | Inhibition of thrombin | ChEMBL. | 11063603 |
Inhibition (binding) | = 70 % | Compound was tested for in vitro inhibitory activity against plasmin at 100 microM | ChEMBL. | 11063603 |
Inhibition (binding) | = 70 % | Compound was tested for in vitro inhibitory activity against plasmin at 100 microM | ChEMBL. | 11063603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.