Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotensin receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | sortilin 1 | Starlite/ChEMBL | References |
Homo sapiens | neurotensin receptor 1 (high affinity) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0586 | 0.5 |
Echinococcus multilocularis | sortilin | 0.0084 | 0.2819 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0586 | 0.3532 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0586 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0027 | 0.0126 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0586 | 1 |
Onchocerca volvulus | 0.0037 | 0.0586 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0029 | 0.02 | 0.1204 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0586 | 0.3532 |
Plasmodium falciparum | sortilin | 0.0084 | 0.2819 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0586 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0586 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0586 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0586 | 0.5 |
Toxoplasma gondii | sortilin, putative | 0.0084 | 0.2819 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0586 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0586 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0586 | 0.1708 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0586 | 0.5 |
Plasmodium vivax | sortilin, putative | 0.0084 | 0.2819 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0041 | 0.0785 | 0.2449 |
Echinococcus granulosus | sortilin | 0.0084 | 0.2819 | 1 |
Schistosoma mansoni | sortilin | 0.0059 | 0.1658 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0586 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0041 | 0.0785 | 0.2449 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0586 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0586 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0586 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0586 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0041 | 0.0785 | 0.4736 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0586 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0586 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0586 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0586 | 1 |
Schistosoma mansoni | peroxidasin | 0.0027 | 0.0126 | 0.0758 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0586 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0586 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0586 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0586 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0586 | 0.1708 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0586 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0586 | 1 |
Onchocerca volvulus | 0.0037 | 0.0586 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.36 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1 | ChEMBL. | 12954066 |
IC50 (binding) | = 0.36 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1 | ChEMBL. | 12954066 |
IC50 (binding) | = 5.1 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 2 | ChEMBL. | 12954066 |
IC50 (binding) | = 5.1 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 2 | ChEMBL. | 12954066 |
IC50 (binding) | = 480 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 3 | ChEMBL. | 12954066 |
IC50 (binding) | = 480 nM | Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 3 | ChEMBL. | 12954066 |
T1/2 (ADMET) | = 126 min | Plasma half life of the compound was determined in rat serum | ChEMBL. | 12954066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.