Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0049 | 0.0821 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0207 | 0.2553 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0054 | 0.0207 | 0.2553 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0049 | 0.0809 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Echinococcus granulosus | carbonic anhydrase II | 0.0054 | 0.0207 | 0.2553 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.004 | 0.0136 | 0.1677 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0594 | 0.7321 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.0416 | 1 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0023 | 0.0049 | 0.00000000052727 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.0427 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0071 | 0.0877 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0071 | 0.0877 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0207 | 0.235 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0054 | 0.0207 | 0.2553 |
Echinococcus multilocularis | geminin | 0.0131 | 0.0594 | 0.7321 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0049 | 0.06 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.0811 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0054 | 0.0207 | 0.4296 |
Leishmania major | DNA repair protein, putative | 0.0023 | 0.0049 | 0.0000000012275 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.0416 | 0.5133 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0054 | 0.0207 | 0.344 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0054 | 0.0207 | 0.4296 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0015 | 0.0012 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.0351 | 0.4332 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.0207 | 0.2553 |
Mycobacterium ulcerans | malate synthase G | 0.1994 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0054 | 0.0207 | 0.344 |
Onchocerca volvulus | DNA ligase 3 homolog | 0.0023 | 0.0049 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.0207 | 0.2553 |
Echinococcus granulosus | geminin | 0.0131 | 0.0594 | 0.7321 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.028 | 0.4657 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.0416 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.0207 | 0.2553 |
Trypanosoma brucei | DNA repair protein, putative | 0.0023 | 0.0049 | 0.00000000052727 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0416 | 0.5133 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0594 | 0.7321 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.0207 | 0.2554 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.0207 | 0.2553 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.0416 | 0.5133 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0049 | 0.06 |
Schistosoma mansoni | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.0207 | 0.2553 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0049 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.0207 | 0.2553 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Leishmania major | carbonic anhydrase-like protein | 0.0054 | 0.0207 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.0416 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.0207 | 0.2553 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.0811 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.0207 | 0.2554 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0416 | 0.6917 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.0207 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0602 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0416 | 0.5133 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.0207 | 0.2553 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0049 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.1994 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0054 | 0.0207 | 0.2553 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.0811 | 1 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0071 | 0.0877 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.0811 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0207 | 0.344 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0207 | 0.344 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.0845 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0025 | 0.0306 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0054 | 0.0207 | 0.4296 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0049 | 0.06 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.0207 | 0.2553 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0054 | 0.0207 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0207 | 0.344 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0027 | 0.0071 | 0.0877 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.0811 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0.0207 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0054 | 0.0207 | 0.344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.