TDR Targets

Basic information

Technical information

TDR Targets ID: 230459
Name: (3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[ (2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamin o)butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbuta noyl]amino]-4-oxobutanoic acid
MW: 610.786 | Formula: C30H54N6O7
H donors: 6 H acceptors: 7 LogP: 2.59 Rotable bonds: 23
Rule of 5 violations (Lipinski): 3
SMILES: CCC(NC(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCCC(C)(C)C)CC(=O)O)CC(=O)N1CCCC1)CC
InChi: 1S/C30H54N6O7/c1-9-19(10-2)32-28(43)35-24(30(6,7)8)27(42)34-20(17-22(37)36-15-11-12-16-36)26(41)33-21(18-23(38)39)25(40)31-14-13-29(3,4)5/h19-21,24H,9-18H2,1-8H3,(H,31,40)(H,33,41)(H,34,42)(H,38,39)(H2,32,35,43)/t20-,21-,24+/m0/s1
InChiKey: IJAJBUCUDNCTMV-AWRGLXIESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-2-(1-ethylpropylcarbamoylamino)-3,3-dimethyl-butanoyl]amino]-4-oxo-4-pyrrolidin-1-yl-butanoyl]amino]-4-oxo-butanoic acid
(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-2-[[(1-ethylpropylamino)-oxomethyl]amino]-3,3-dimethyl-1-oxobutyl]amino]-1,4-dioxo-4-(1-pyrrolidinyl)butyl]amino]-4-oxobutanoic acid
(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-(pentan-3-ylcarbamoylamino)butanoyl]amino]-4-oxo-4-pyrrolidin-1-yl-butanoyl]amino]-4-oxo-butanoic acid
(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-2-(1-ethylpropylcarbamoylamino)-3,3-dimethyl-butanoyl]amino]-4-keto-4-pyrrolidino-butanoyl]amino]-4-keto-butyric acid
(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-2-[[(1-ethylpropylamino)-oxomethyl]amino]-3,3-dimethyl-1-oxobutyl]amino]-1,4-dioxo-4-1-pyrrolidinylbutyl]amino]-4-oxobutanoic acid
(3S)-4-(3,3-dimethylbutylamino)-3-[[(2S)-2-[[(2S)-2-(1-ethylpropylcarbamoylamino)-3,3-dimethyl-butanoyl]amino]-4-keto-4-pyrrolidin-1-yl-butanoyl]amino]-4-keto-butyric acid
AIDS-191706
AIDS191706
N-(3,3-Dimethyl-butyl)-3-(2-{2-[3-(1-ethyl-propyl)-ureido]-3,3-dimethyl-butyrylamino}-4-oxo-4-pyrrolidin-1-yl-butyrylamino)-succinamic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribonucleotide reductase M1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	Get druggable targets OG5_126839	All targets in OG5_126839
Cryptosporidium parvum	ribonucleotide-diphosphate reductase large chain; RIR1; c-terminal PFL-like glycyl radical enzymes-like fold	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania donovani	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Cryptosporidium hominis	ribonucleoside-diphosphate reductase large chain (ribonucleotide reductase R1 subunit)	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma brucei gambiense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Neospora caninum	ribonucleoside-diphosphate reductase, large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium yoelii	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Babesia bovis	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium berghei	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma congolense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma congolense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	Get druggable targets OG5_126839	All targets in OG5_126839
Echinococcus granulosus	ribonucleoside diphosphate reductase large	Get druggable targets OG5_126839	All targets in OG5_126839
Schistosoma japonicum	ko:K00525 ribonucleoside-diphosphate reductase alpha chain [EC1.17.4.1A], putative	Get druggable targets OG5_126839	All targets in OG5_126839
Theileria parva	ribonucleotide-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania braziliensis	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania infantum	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	Get druggable targets OG5_126839	All targets in OG5_126839
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium knowlesi	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	opsin-like receptor	0.014	0.347	1
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0102	0.2396	0.3362
Loa Loa (eye worm)	calpain family protein 1	0.004	0.0604	0.0954
Schistosoma mansoni	opsin-like receptor	0.014	0.347	1
Brugia malayi	polk-prov protein	0.003	0.0334	0.0541
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.347	0.3459
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus multilocularis	expressed protein	0.0369	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.014	0.347	0.3459
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0121	0.2939	0.2927
Brugia malayi	Serotonin receptor	0.014	0.347	0.5625
Brugia malayi	calpain family protein 1	0.0054	0.1008	0.1634
Echinococcus granulosus	neuropeptide Y receptor	0.014	0.347	0.3459
Onchocerca volvulus		0.014	0.347	0.4575
Loa Loa (eye worm)	G-protein coupled receptor	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.0033	0.043	0.0672
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0414	0.0398
Echinococcus multilocularis	neuropeptide Y receptor	0.014	0.347	0.3459
Echinococcus granulosus	chromobox protein 1	0.0079	0.1717	0.1703
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.347	1
Echinococcus multilocularis	chromobox protein 1	0.0079	0.1717	0.1703
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0017	0.0028
Loa Loa (eye worm)	calpain family protein 1	0.0054	0.1008	0.161
Echinococcus granulosus	sex peptide receptor	0.014	0.347	0.3459
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0287	0.0808
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.014	0.347	0.5625
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Echinococcus granulosus	serotonin receptor	0.014	0.347	0.3459
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.347	1
Echinococcus multilocularis	neuropeptides capa receptor	0.014	0.347	0.3459
Onchocerca volvulus		0.014	0.347	0.4575
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0037	0.0526	0.2132
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0437	0.1215
Onchocerca volvulus		0.014	0.347	0.4575
Brugia malayi	Dopamine receptor protein 1	0.014	0.347	0.5625
Brugia malayi	hypothetical protein	0.0019	0.0017	0.0028
Echinococcus multilocularis	neuropeptide s receptor	0.014	0.347	0.3459
Schistosoma mansoni	jumonji domain containing protein	0.0085	0.1916	0.55
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.014	0.347	0.4575
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0437	0.042
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0017	0.0028
Schistosoma mansoni	neuropeptide receptor	0.014	0.347	1
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus granulosus	peptide allatostatin:somatostatin	0.014	0.347	0.3459
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0828	0.1146
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.1296	0.4306
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0414	0.0645
Schistosoma mansoni	growth hormone secretagogue receptor	0.014	0.347	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.014	0.347	0.3459
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.1296	0.2079
Brugia malayi	calpain 7	0.002	0.0054	0.0088
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Echinococcus granulosus	calpain A	0.002	0.0054	0.0037
Brugia malayi	hypothetical protein	0.0035	0.0468	0.0759
Schistosoma mansoni	neuropeptide F-like receptor	0.014	0.347	1
Brugia malayi	PXA domain containing protein	0.0019	0.0017	0.0028
Echinococcus granulosus	neuropeptides capa receptor	0.014	0.347	0.3459
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0468	0.0452
Echinococcus multilocularis	neuropeptides capa receptor	0.014	0.347	0.3459
Schistosoma mansoni	calpain-7 (C02 family)	0.0023	0.0137	0.0346
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0017	0.0028
Schistosoma mansoni	amine GPCR	0.014	0.347	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.014	0.347	0.3459
Entamoeba histolytica	hypothetical protein	0.0035	0.0468	0.3528
Echinococcus multilocularis	serotonin receptor	0.014	0.347	0.3459
Echinococcus granulosus	hypothetical protein	0.014	0.347	0.3459
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0058	0.0011
Brugia malayi	Tachykinin-like peptides receptor 99D	0.014	0.347	0.5625
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Brugia malayi	neuropeptide F receptor	0.014	0.347	0.5625
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0056	0.1077	0.1062
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.347	0.3459
Loa Loa (eye worm)	heterochromatin protein 1	0.0079	0.1717	0.2763
Onchocerca volvulus		0.014	0.347	0.4575
Loa Loa (eye worm)	neuropeptide F receptor	0.014	0.347	0.5612
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0287	0.0808
Onchocerca volvulus		0.014	0.347	0.4575
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0461	0.0722
Brugia malayi	jmjC domain containing protein	0.004	0.0611	0.0991
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0102	0.2396	1
Brugia malayi	jmjC domain containing protein	0.0108	0.2547	0.4129
Brugia malayi	putative neuropeptide receptor NPR1	0.014	0.347	0.5625
Brugia malayi	PXA domain containing protein	0.0019	0.0017	0.0028
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.1717	0.2402
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.014	0.347	0.3459
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.014	0.347	0.3459
Brugia malayi	PHD-finger family protein	0.0033	0.0414	0.0671
Schistosoma mansoni	opsin-like receptor	0.014	0.347	1
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0611	0.0595
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.014	0.347	0.3459
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.2547	0.2534
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0609	0.0593
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.014	0.347	1
Schistosoma mansoni	neuropeptide receptor	0.014	0.347	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.014	0.347	0.5625
Echinococcus granulosus	alpha 1A adrenergic receptor	0.014	0.347	0.3459
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0121	0.2939	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0828	0.0619
Brugia malayi	Bromodomain containing protein	0.0033	0.0414	0.0671
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Echinococcus granulosus	neuropeptide receptor	0.014	0.347	0.3459
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.014	0.347	0.5625
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	neuropeptide F-like receptor	0.014	0.347	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Onchocerca volvulus		0.014	0.347	0.4575
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0058	0.016
Schistosoma mansoni	neuropeptide f receptor 76f	0.014	0.347	1
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.2939	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0366	0.0493
Onchocerca volvulus	Neuropeptide F receptor homolog	0.014	0.347	0.4575
Loa Loa (eye worm)	melatonin receptor type 1A	0.014	0.347	0.5612
Echinococcus multilocularis	fmrfamide receptor	0.014	0.347	0.3459
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.1296	0.1281
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.014	0.347	0.3459
Onchocerca volvulus		0.014	0.347	0.4575
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0102	0.2396	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0468	0.1307
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0611	0.1721
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.014	0.347	0.5625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0056	0.1077	0.1062
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.014	0.347	0.5612
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus multilocularis	allatostatin A receptor	0.014	0.347	0.3459
Trypanosoma brucei	unspecified product	0.0033	0.0427	0.1292
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	neuropeptide receptor A26	0.014	0.347	0.3459
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.014	0.347	0.5612
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0414	0.0479
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	orexin receptor type 2	0.014	0.347	0.3459
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.1296	0.3705
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.1077	0.307
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Schistosoma mansoni	biogenic amine receptor	0.014	0.347	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.014	0.347	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	histamine h1 receptor	0.014	0.347	1
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.0781	0.0766
Schistosoma mansoni	amine GPCR	0.014	0.347	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0733	0.1011
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0437	0.1215
Echinococcus multilocularis	neuropeptide FF receptor 2	0.014	0.347	0.3459
Brugia malayi	ORL1-like opioid receptor	0.014	0.347	0.5625
Echinococcus multilocularis	peregrin	0.0033	0.0414	0.0398
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0609	0.1922
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.4306
Schistosoma mansoni	biogenic amine receptor	0.014	0.347	1
Schistosoma mansoni	biogenic amine receptor	0.014	0.347	1
Brugia malayi	follicle stimulating hormone receptor	0.014	0.347	0.5625
Brugia malayi	larval opioid receptor	0.014	0.347	0.5625
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.1296	0.1281
Echinococcus granulosus	neuropeptide s receptor	0.014	0.347	0.3459
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0287	0.0808
Schistosoma mansoni	chromobox protein	0.0079	0.1717	0.4923
Echinococcus multilocularis	g protein coupled receptor	0.014	0.347	0.3459
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.0781	0.0766
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.2939	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.014	0.347	0.3459
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0733	0.0477
Schistosoma mansoni	Mername-AA248 (C02 family)	0.002	0.0054	0.0108
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Echinococcus multilocularis	g protein coupled receptor	0.014	0.347	0.3459
Echinococcus granulosus	g protein coupled receptor	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0414	0.0645
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.014	0.347	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.014	0.347	0.3459
Leishmania major	hypothetical protein, conserved	0.0028	0.0287	0.0808
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.014	0.347	0.3459
Echinococcus granulosus	neuropeptide receptor	0.014	0.347	0.3459
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Echinococcus multilocularis	serotonin receptor	0.014	0.347	0.3459
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0414	0.0479
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.014	0.347	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.1077	0.307
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.014	0.347	0.3459
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.014	0.347	1
Echinococcus multilocularis	g-protein coupled receptor	0.014	0.347	0.3459
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0121	0.2939	1
Echinococcus multilocularis	calpain family protein 1, d	0.004	0.0604	0.0588
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.014	0.347	0.3459
Brugia malayi	hypothetical protein	0.0019	0.0017	0.0028
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0609	0.0836
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.014	0.347	1
Brugia malayi	Serotonin receptor	0.014	0.347	0.5625
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.014	0.347	0.3459
Echinococcus granulosus	calpain 5	0.002	0.0054	0.0037
Loa Loa (eye worm)	TYRA-2 protein	0.014	0.347	0.5612
Echinococcus granulosus	7TM GPCR rhodopsin	0.014	0.347	0.3459
Schistosoma mansoni	alpha-1 adrenergic receptor	0.014	0.347	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.014	0.347	0.5625
Entamoeba histolytica	hypothetical protein	0.0035	0.0468	0.3528
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.014	0.347	1
Echinococcus granulosus	neuropeptides capa receptor	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus granulosus	calpain 7 C02 family	0.002	0.0054	0.0037
Echinococcus multilocularis	calpain 5	0.002	0.0054	0.0037
Echinococcus multilocularis	hypothetical protein	0.002	0.0054	0.0037
Echinococcus multilocularis	lysine specific demethylase 5A	0.004	0.0611	0.0595
Echinococcus multilocularis	somatostatin receptor	0.014	0.347	0.3459
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.014	0.347	0.3459
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0334	0.0968
Echinococcus granulosus	G protein coupled receptor 139	0.014	0.347	0.3459
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.014	0.347	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.014	0.347	0.3459
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.2939	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.014	0.347	0.3459
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0102	0.2396	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.014	0.347	0.3459
Echinococcus multilocularis	calpain 7 (C02 family)	0.002	0.0054	0.0037
Echinococcus granulosus	tachykinin peptides receptor 99D	0.014	0.347	0.3459
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.4306
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Echinococcus multilocularis	chromobox protein 1	0.0079	0.1717	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0733	0.1163
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	amine GPCR	0.014	0.347	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.014	0.347	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	neuropeptide receptor	0.014	0.347	0.3459
Schistosoma mansoni	calpain C (C02 family)	0.002	0.0054	0.0108
Echinococcus granulosus	g-protein coupled receptor	0.014	0.347	0.3459
Schistosoma mansoni	hypothetical protein	0.014	0.347	1
Echinococcus granulosus	g protein coupled receptor	0.014	0.347	0.3459
Schistosoma mansoni	hypothetical protein	0.014	0.347	1
Schistosoma mansoni	neuropeptide receptor	0.014	0.347	1
Onchocerca volvulus		0.0033	0.043	0.0024
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.014	0.347	0.3459
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.1717	0.2402
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0414	0.0398
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0414	0.0479
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Brugia malayi	Pre-SET motif family protein	0.0034	0.0437	0.0708
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0401	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0366	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0287	0.0439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0334	0.0968
Brugia malayi	calpain family protein 1	0.0054	0.1008	0.1634
Schistosoma mansoni	calpain-7 (C02 family)	0.0023	0.0137	0.0346
Echinococcus multilocularis	neuropeptide Y receptor	0.014	0.347	0.3459
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.014	0.347	1
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0609	0.2479
Brugia malayi	Pre-SET motif family protein	0.0235	0.6169	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	calpain	0.002	0.0054	0.006
Echinococcus granulosus	dro:myosuppressin receptor	0.014	0.347	0.3459
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Brugia malayi	AKH receptor	0.014	0.347	0.5625
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0414	0.1248
Entamoeba histolytica	hypothetical protein	0.0035	0.0468	0.3528
Echinococcus multilocularis	g protein coupled receptor	0.014	0.347	0.3459
Brugia malayi	hypothetical protein	0.0028	0.0287	0.0466
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	hypothetical protein	0.0035	0.0468	0.1307
Trichomonas vaginalis	set domain proteins, putative	0.0267	0.7094	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0733	0.1011
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0058	0.0011
Onchocerca volvulus		0.0267	0.7094	1
Echinococcus granulosus	neuropeptide receptor A26	0.014	0.347	0.3459
Schistosoma mansoni	neuropeptide receptor	0.014	0.347	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.347	1
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0121	0.2939	0.8462
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.6169	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0437	0.042
Brugia malayi	RE15519p	0.014	0.347	0.5625
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.2547	0.2534
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0828	0.1146
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.1412	0.2268
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.1296	0.4306
Brugia malayi	G-protein coupled receptor	0.014	0.347	0.5625
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0609	0.2479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.014	0.347	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.014	0.347	0.5612
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.347	0.3459
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0046	0.0803	0.2277
Brugia malayi	Dopamine receptor protein 2	0.014	0.347	0.5625
Schistosoma mansoni	biogenic amine (5HT) receptor	0.014	0.347	1
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Loa Loa (eye worm)	hypothetical protein	0.004	0.0604	0.0954
Brugia malayi	neuropeptide F receptor	0.014	0.347	0.5625
Echinococcus granulosus	calpain	0.002	0.0054	0.0037
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.2939	0.4764
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0121	0.2939	0.2927
Brugia malayi	Heterochromatin protein 1	0.0079	0.1717	0.2783
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0017	0.0028
Onchocerca volvulus		0.014	0.347	0.4575
Onchocerca volvulus		0.014	0.347	0.4575
Echinococcus multilocularis	fmrfamide receptor	0.014	0.347	0.3459
Brugia malayi	sulfakinin receptor protein	0.014	0.347	0.5625
Schistosoma mansoni	hypothetical protein	0.005	0.0902	0.2564
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.1296	1
Echinococcus granulosus	chromobox protein 1	0.0079	0.1717	0.1703
Echinococcus multilocularis	G protein coupled receptor 139	0.014	0.347	0.3459
Echinococcus multilocularis	neuropeptide receptor	0.014	0.347	0.3459
Schistosoma mansoni	calpain (C02 family)	0.002	0.0054	0.0108
Schistosoma mansoni	amine GPCR	0.014	0.347	1
Echinococcus granulosus	allatostatin A receptor	0.014	0.347	0.3459
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0121	0.2939	0.4749
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0834	0.1328
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0017	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.014	0.347	0.3459
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.1296	0.2102
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0437	0.1215
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0609	0.1922
Onchocerca volvulus		0.014	0.347	0.4575
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus granulosus	g protein coupled receptor	0.014	0.347	0.3459
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus granulosus	orexin receptor type 2	0.014	0.347	0.3459
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Loa Loa (eye worm)	G-protein coupled receptor	0.014	0.347	0.5612
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.347	0.3459
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0437	0.0563
Schistosoma mansoni	adenoreceptor	0.014	0.347	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0287	0.0808
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.014	0.347	0.3459
Echinococcus granulosus	dna polymerase kappa	0.004	0.0609	0.0593
Echinococcus granulosus	peregrin	0.0033	0.0414	0.0398
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Leishmania major	DNA polymerase kappa, putative	0.002	0.0058	0.0011
Brugia malayi	putative neuropeptide receptor	0.014	0.347	0.5625
Onchocerca volvulus		0.014	0.347	0.4575
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1084	0.1734
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Echinococcus multilocularis	sex peptide receptor	0.014	0.347	0.3459
Trypanosoma brucei	DNA polymerase IV, putative	0.0033	0.0427	0.1292
Echinococcus granulosus	neuropeptide Y receptor	0.014	0.347	0.3459
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Plasmodium vivax	SET domain protein, putative	0.0034	0.0437	0.1325
Brugia malayi	chromobox protein homolog 3	0.0044	0.0733	0.1187
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.014	0.347	0.5625
Schistosoma mansoni	myosin xvIII	0.014	0.347	1
Brugia malayi	GnHR receptor homolog	0.014	0.347	0.5625
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0121	0.2939	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1008	0.161
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0031	0.0372	0.1102
Echinococcus multilocularis	calpain A	0.0056	0.1077	0.1062
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.053	0.0514
Schistosoma mansoni	hypothetical protein	0.0033	0.0414	0.115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0609	0.1922
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus granulosus	somatostatin receptor	0.014	0.347	0.3459
Onchocerca volvulus		0.014	0.347	0.4575
Brugia malayi	Dopamine receptor	0.014	0.347	0.5625
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.053	0.0514
Brugia malayi	G-protein coupled receptor	0.014	0.347	0.5625
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0437	0.0682
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	calpain	0.002	0.0054	0.0037
Giardia lamblia	PHD finger protein 15	0.0033	0.0414	1
Onchocerca volvulus		0.0046	0.0803	0.0583
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0102	0.2396	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Entamoeba histolytica	hypothetical protein	0.0035	0.0468	0.3528
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0611	0.0966
Schistosoma mansoni	hypothetical protein	0.014	0.347	1
Brugia malayi	hypothetical protein	0.014	0.347	0.5625
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	amine GPCR	0.014	0.347	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0468	0.0452
Brugia malayi	G protein-coupled receptor	0.014	0.347	0.5625
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0414	0.115
Loa Loa (eye worm)	hypothetical protein	0.003	0.0334	0.0514
Brugia malayi	Melatonin receptor type 1A	0.014	0.347	0.5625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.347	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.347	0.3459
Loa Loa (eye worm)	neuropeptide F receptor	0.014	0.347	0.5612
Schistosoma mansoni	hypothetical protein	0.014	0.347	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.347	0.3459
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0121	0.2939	0.5
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0017	0.0028
Echinococcus granulosus	fmrfamide receptor	0.014	0.347	0.3459
Echinococcus granulosus	neuropeptide FF receptor 2	0.014	0.347	0.3459
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0054	0.1008	0.2869
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0121	0.2939	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0437	0.042
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0611	0.1721
Schistosoma mansoni	chromobox protein	0.0079	0.1717	0.4923
Onchocerca volvulus		0.0035	0.0461	0.007
Echinococcus multilocularis	G-protein coupled receptor, putative	0.014	0.347	0.3459
Echinococcus granulosus	biogenic amine 5HT receptor	0.014	0.347	0.3459
Echinococcus granulosus	calpain A	0.0056	0.1077	0.1062
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0609	0.0836
Loa Loa (eye worm)	hypothetical protein	0.014	0.347	0.5612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.347	0.3459

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 100 nM	Inhibitory effect of the compound was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.	ChEMBL.	8863795
IC50 (binding)	= 100 nM	Inhibitory effect of the compound was evaluated on Herpes simplex virus (HSV) ribonucleotide reductase (RR) enzyme.	ChEMBL.	8863795

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 515279

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 230459