Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0291 | 1 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.009 | 0.206 | 0.1622 |
Echinococcus granulosus | peroxidasin | 0.0275 | 0.9377 | 0.9343 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.5824 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6042 | 0.599 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0291 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Brugia malayi | Peroxidasin | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.206 | 0.1202 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0078 | 0.1582 | 0.0092 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Brugia malayi | WGR domain containing protein | 0.0163 | 0.4961 | 0.3654 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0275 | 0.9377 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0163 | 0.4961 | 0.4683 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0201 | 0.6444 | 0.6474 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3423 | 0.2842 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.01 | 0.248 | 0.053 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.009 | 0.2078 | 0.0023 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.9271 | 0.9873 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.9271 | 0.9142 |
Brugia malayi | Blistered cuticle protein 3 | 0.0275 | 0.9377 | 0.9216 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.9271 | 0.9873 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0101 | 0.2487 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0291 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.009 | 0.206 | 0.206 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.1504 | 0.1036 |
Schistosoma mansoni | peroxidasin | 0.0275 | 0.9377 | 0.9267 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0291 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0275 | 0.9377 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0275 | 0.9377 | 0.5 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0291 | 1 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.009 | 0.206 | 0.0654 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0163 | 0.4961 | 0.4961 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.009 | 0.2078 | 0.0023 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.1504 | 0.1504 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0191 | 0.6036 | 0.5008 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0191 | 0.6042 | 0.6042 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0191 | 0.6042 | 0.4737 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0291 | 1 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.9377 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0275 | 0.9377 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0275 | 0.9377 | 0.9216 |
Echinococcus multilocularis | peroxidasin | 0.0275 | 0.9377 | 0.9377 |
Brugia malayi | hypothetical protein | 0.0275 | 0.9377 | 0.9216 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0163 | 0.4961 | 0.4069 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.009 | 0.2078 | 0.0023 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.9271 | 0.9031 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0191 | 0.6042 | 0.599 |
Onchocerca volvulus | 0.0275 | 0.9377 | 0.5 | |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0291 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.009 | 0.2078 | 0.0023 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0291 | 1 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.9271 | 0.9082 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 M | Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
IC50 (functional) | = 5.6 M | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea . | ChEMBL. | 1560434 |
Inhibition (functional) | = 17 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 58.3 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 3*10e-6 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 80.4 % | Inhibitory activity of the Compound was tested against U-46619 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Inhibition (functional) | = 95 % | Inhibitory activity of the Compound was tested against LTD4 induced contraction of guinea pig trachea at 2*10e-5 M concentration. | ChEMBL. | 1560434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.