Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate carboxypeptidase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to secretory protein Ssp134p | Glutamate carboxypeptidase II | 752 aa | 717 aa | 23.4 % |
Candida albicans | similar to secretory protein Ssp134p | Glutamate carboxypeptidase II | 752 aa | 717 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0119 | 0.0362 | 0.0362 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0179 | 0.0977 | 0.0977 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0179 | 0.0977 | 0.0638 |
Leishmania major | hypothetical protein, conserved | 0.0179 | 0.0977 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0179 | 0.0977 | 0.0638 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0332 | 0.2518 | 0.2237 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0179 | 0.0977 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0179 | 0.0977 | 0.0977 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0183 | 0.1017 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0179 | 0.0977 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0179 | 0.0977 | 0.0638 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0179 | 0.0977 | 0.0638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0977 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0977 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.107 | 1 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.107 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0179 | 0.0977 | 0.0977 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0179 | 0.0977 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0977 | 0.0297 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0179 | 0.0977 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.107 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0179 | 0.0977 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0183 | 0.1017 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0179 | 0.0977 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0179 | 0.0977 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0275 | 0.1949 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0977 | 0.0297 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0179 | 0.0977 | 0.0297 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0977 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1989 | 0.1386 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.107 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.107 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.2559 | 0.1998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.