Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Dopamine D1 receptor | 446 aa | 394 aa | 29.9 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D1 receptor | 446 aa | 370 aa | 24.9 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D1 receptor | 446 aa | 366 aa | 35.2 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Onchocerca volvulus | Dopamine D1 receptor | 446 aa | 357 aa | 21.0 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine D1 receptor | 446 aa | 407 aa | 33.7 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D1 receptor | 446 aa | 373 aa | 25.5 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.73 | Binding affinity against dopamine receptor D1 | ChEMBL. | 7996543 |
Ki (binding) | = -6.53 | Binding affinity against dopamine (D2) receptor | ChEMBL. | 7996543 |
Ki (binding) | = 290 nM | Binding affinity towards dopamine (D1) receptor using [3H]-spiperone was determined in rat striatal membranes | ChEMBL. | 7996543 |
Ki (binding) | = 290 nM | Binding affinity towards dopamine (D1) receptor using [3H]-spiperone was determined in rat striatal membranes | ChEMBL. | 7996543 |
Ki (binding) | = 370 nM | Binding affinity towards dopamine receptor D1 using [3H]-SCH-23,390 was determined in rat striatal membranes | ChEMBL. | 7996543 |
Ki (binding) | = 370 nM | Binding affinity towards dopamine receptor D1 using [3H]-SCH-23,390 was determined in rat striatal membranes | ChEMBL. | 7996543 |
Log Ki (binding) | = 6.53 M | Binding affinity against dopamine (D2) receptor | ChEMBL. | 7996543 |
Log Ki (binding) | = 6.73 M | Binding affinity against dopamine receptor D1 | ChEMBL. | 7996543 |
Ratio (binding) | = 1.27 | Selectivity for D1 receptor was determined as the ratio of Ki (D2) to that of Ki (D1) | ChEMBL. | 7996543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.