Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0169 | 0.1926 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0217 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0217 | 0.0819 |
Onchocerca volvulus | 0.0036 | 0.0217 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0217 | 1 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0226 | 0.2652 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2667 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0217 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0217 | 0.0814 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0217 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0217 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0217 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0217 | 0.0814 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0217 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.1926 | 0.7262 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0217 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0217 | 0.1127 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0217 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0217 | 0.0814 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.1926 | 0.7262 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0217 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0217 | 0.0814 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0169 | 0.1926 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0226 | 0.2652 | 1 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0057 | 0.0489 | 0.2537 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0217 | 0.0814 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0057 | 0.0489 | 0.2537 |
Onchocerca volvulus | 0.0036 | 0.0217 | 0.5 | |
Plasmodium falciparum | topoisomerase I | 0.0226 | 0.2652 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0217 | 0.0819 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.2652 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0226 | 0.2652 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0217 | 0.0819 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0217 | 0.0814 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0217 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0226 | 0.2652 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0217 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0217 | 0.0819 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0226 | 0.2652 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0217 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0217 | 0.0814 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0169 | 0.1926 | 1 |
Onchocerca volvulus | 0.0036 | 0.0217 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0217 | 0.0819 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0217 | 0.1127 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0217 | 0.0217 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0217 | 0.1127 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0217 | 0.0814 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0217 | 0.0814 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0057 | 0.0489 | 0.2537 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0226 | 0.2652 | 0.2652 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0819 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0217 | 0.0814 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC200 (functional) | > 10 uM | Effect on the formation of protein-DNA complex in P388 cells K+/SDS method | ChEMBL. | 10340602 |
EC200 (functional) | > 10 uM | Effect on the formation of protein-DNA complex in P388 cells K+/SDS method | ChEMBL. | 10340602 |
EC50 (functional) | = 0.58 uM | In vitro activity against topoisomerase-I mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | = 0.58 uM | In vitro activity against topoisomerase-I mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | > 50 uM | In vitro activity against topoisomerase-II mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
EC50 (functional) | > 50 uM | In vitro activity against topoisomerase-II mediated cleavage of supercoiled pBR322 plasmid DNA | ChEMBL. | 10340602 |
IC50 (functional) | = 0.06 uM | In vitro cytotoxicity (CTX) against murine leukemia cells (P388) using colorimeric tetrazolium-formazan method | ChEMBL. | 10340602 |
IC50 (functional) | = 0.06 uM | In vitro cytotoxicity (CTX) against murine leukemia cells (P388) using colorimeric tetrazolium-formazan method | ChEMBL. | 10340602 |
IC50 (functional) | = 0.27 uM | In vitro cytotoxicity (CTX) against human stomach cancer cells (MKN-45) using sulforhodamine B dye-staining method | ChEMBL. | 10340602 |
IC50 (functional) | = 0.27 uM | In vitro cytotoxicity (CTX) against human stomach cancer cells (MKN-45) using sulforhodamine B dye-staining method | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity against Epidermal growth factor receptor (using poly(Glu4Tyr1) as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity evaluated against protein kinase C (using histone II-As as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity against Epidermal growth factor receptor (using poly(Glu4Tyr1) as a substrate) | ChEMBL. | 10340602 |
IC50 (binding) | > 200 uM | In vitro activity evaluated against protein kinase C (using histone II-As as a substrate) | ChEMBL. | 10340602 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10340602 | |
Mus musculus | ChEMBL23 | 10340602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.