Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.4172 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.1528 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.1528 | 0.3662 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.0672 | 0.4398 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.029 | 0.1896 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1528 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0135 | 0.0885 | 0.2488 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.0977 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1528 | 0.4953 |
Leishmania major | farnesyltransferase beta subunit | 0.0135 | 0.0885 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1325 | 0.339 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0135 | 0.0885 | 0.2002 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.1528 | 0.3461 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.1528 | 1 |
Brugia malayi | hypothetical protein | 0.0433 | 0.4172 | 0.9465 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0135 | 0.0885 | 0.2121 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.1528 | 0.4953 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0135 | 0.0885 | 0.5791 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0135 | 0.0885 | 0.3849 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1528 | 0.4953 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0961 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.1325 | 0.339 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0135 | 0.0885 | 0.5791 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0135 | 0.0885 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.1528 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.1528 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1528 | 0.3662 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0003 | 0.0008 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.1227 | 0.2633 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.1528 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.0977 | 0.0707 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0461 | 0.4489 | 0.5 |
Onchocerca volvulus | 0.0433 | 0.4172 | 1 | |
Brugia malayi | Serotonin receptor | 0.0454 | 0.4408 | 1 |
Trypanosoma brucei | beta lactamase | 0.0461 | 0.4489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.4172 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.2183 | 0.4949 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.0672 | 0.4398 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.2183 | 1 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0135 | 0.0885 | 0.5 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.1528 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.2183 | 0.5233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | ND 0 nM | Inhibition of anchorage-independent growth of NIH-H tumor cell lines in soft agar. | ChEMBL. | 9822558 |
IC50 (binding) | > 95 nM | Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransferase to H-Ras-CVLS, a process that is mediated by FPT | ChEMBL. | 9822558 |
IC50 (binding) | > 95 nM | Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransferase to H-Ras-CVLS, a process that is mediated by FPT | ChEMBL. | 9822558 |
IC50 (functional) | = 2250 nM | Inhibiting the farnesylation of H-ras proteins in COS-7 monkey cells transiently expressing H-ras[Val12]-CVLS in the whole cell assay. | ChEMBL. | 9822558 |
IC50 (functional) | = 2250 nM | Inhibiting the farnesylation of H-ras proteins in COS-7 monkey cells transiently expressing H-ras[Val12]-CVLS in the whole cell assay. | ChEMBL. | 9822558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.