Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.4075 | 0.3759 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.3965 | 0.3965 |
Brugia malayi | peptidase family M13 containing protein | 0.0056 | 0.0953 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3213 | 0.3213 |
Schistosoma mansoni | neprilysin | 0.006 | 0.1161 | 0.0691 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.015 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.006 | 0.1161 | 0.0691 |
Onchocerca volvulus | 0.0113 | 0.3965 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.6879 | 0.6879 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0228 | 1 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0099 | 0.3213 | 0.3213 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.6879 | 0.6879 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.6879 | 0.6879 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.015 | 0.5 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0056 | 0.0953 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3213 | 0.3213 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0953 | 0.0471 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0115 | 0.4075 | 0.3759 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.6879 | 0.6879 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0115 | 0.4075 | 0.3759 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0228 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0953 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3213 | 0.3213 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0115 | 0.4075 | 0.3759 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.4075 | 0.3759 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.6879 | 0.6879 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.6879 | 0.6879 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0056 | 0.0953 | 0.0953 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0953 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7087 | 0.7087 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0056 | 0.0953 | 0.0471 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0228 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1161 | 0.0691 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0056 | 0.0953 | 0.0471 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65 nM | In Vitro inhibition of recombinant human endothelin converting enzyme-1 | ChEMBL. | 10669576 |
IC50 (binding) | = 65 nM | In Vitro inhibition of recombinant human endothelin converting enzyme-1 | ChEMBL. | 10669576 |
IC50 (binding) | > 16000 nM | In vitro inhibition of rat neutral endopeptidase | ChEMBL. | 10669576 |
IC50 (binding) | > 16000 nM | In vitro inhibition of rat neutral endopeptidase | ChEMBL. | 10669576 |
Inhibition (binding) | = 89 % | Inhibition of Endothelin-converting enzyme 1 activity at a concentration of 1 uM | ChEMBL. | 10669576 |
Inhibition (binding) | = 89 % | Inhibition of Endothelin-converting enzyme 1 activity at a concentration of 1 uM | ChEMBL. | 10669576 |
Selectivity (binding) | ND 0 | Selectivity ratio of IC50 NEP (rat kidney cortex membranes) /IC50 ECE (human recombinant ECE-1a) | ChEMBL. | 10669576 |
Selectivity (binding) | > 286 | Selectivity ratio of IC50 NEP/IC50 ECE | ChEMBL. | 10669576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.