Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.655 | 0.655 |
Onchocerca volvulus | 0.0113 | 0.3329 | 1 | |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0115 | 0.345 | 0.345 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0228 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.655 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.345 | 0.345 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1458 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.345 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0081 | 0.1458 | 0.1458 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0081 | 0.1458 | 0.1458 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0228 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0228 | 1 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Toxoplasma gondii | peptidase family M13 protein | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Schistosoma mansoni | neprilysin | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.3329 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.678 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1135 | 0.1135 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.655 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.655 | 0.655 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1458 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.655 | 0.655 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.655 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0115 | 0.345 | 0.345 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.006 | 0.023 | 0.023 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0115 | 0.345 | 0.345 |
Brugia malayi | Cation transporter family protein | 0.0081 | 0.1458 | 0.1458 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140 nM | In vitro inhibition of rat neutral endopeptidase | ChEMBL. | 10669576 |
IC50 (binding) | = 140 nM | In vitro inhibition of rat neutral endopeptidase | ChEMBL. | 10669576 |
IC50 (binding) | > 4000 nM | In Vitro inhibition of recombinant human endothelin converting enzyme-1 | ChEMBL. | 10669576 |
IC50 (binding) | > 4000 nM | In Vitro inhibition of recombinant human endothelin converting enzyme-1 | ChEMBL. | 10669576 |
Selectivity (binding) | < 0.03 | Selectivity ratio of IC50 NEP/IC50 ECE | ChEMBL. | 10669576 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.