Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0239 | 0.7701 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.2347 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0094 | 0.2299 | 0.2762 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.2347 | 0.4452 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0215 | 0.6806 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0094 | 0.2299 | 0.9796 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0033 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0094 | 0.2299 | 1 |
Brugia malayi | glutathione reductase | 0.0094 | 0.2299 | 0.2762 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.2347 | 0.4452 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0094 | 0.2299 | 0.4361 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0134 | 0.3809 | 0.3809 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0266 | 0.8728 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0033 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0239 | 0.7701 | 1 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.2347 | 0.2819 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0033 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0215 | 0.6806 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.004 | 0.027 | 0.0513 |
Mycobacterium tuberculosis | Probable reductase | 0.0215 | 0.6806 | 0.8837 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.5271 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.1865 | 0.1865 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0134 | 0.3809 | 0.7226 |
Loa Loa (eye worm) | glutathione reductase | 0.0094 | 0.2299 | 0.1375 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0124 | 0.3405 | 0.6459 |
Plasmodium falciparum | thioredoxin reductase | 0.0094 | 0.2299 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.5271 | 1 |
Treponema pallidum | NADH oxidase | 0.0033 | 0 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.5271 | 0.6333 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.7963 | 0.9483 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.5525 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0033 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0094 | 0.2299 | 0.9796 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0239 | 0.7701 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0094 | 0.2299 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.2347 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0239 | 0.7701 | 1 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.0797 | 0.1512 |
Toxoplasma gondii | thioredoxin reductase | 0.0094 | 0.2299 | 0.4161 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.2347 | 0.2347 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3721 | 0.3411 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0255 | 0.8324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2347 | 0.1443 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.2347 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.5271 | 0.5271 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0215 | 0.6806 | 0.8837 |
Brugia malayi | nuclear hormone receptor | 0.0255 | 0.8324 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0215 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0094 | 0.2299 | 0.2985 |
Plasmodium falciparum | glutathione reductase | 0.0094 | 0.2299 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0094 | 0.2299 | 0.1375 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0094 | 0.2299 | 0.4361 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.5271 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.0797 | 0.1512 |
Leishmania major | trypanothione reductase | 0.0094 | 0.2299 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0215 | 0.6806 | 0.8837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.23 uM | In vitro inhibitory activity towards human poly(ADP-ribose) polymerase 1 (PARP-1). | ChEMBL. | 12408707 |
Ki (binding) | = 0.23 uM | In vitro inhibitory activity towards human poly(ADP-ribose) polymerase 1 (PARP-1). | ChEMBL. | 12408707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.