Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | unspecified product | 0.0229 | 0.2157 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.2303 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0229 | 0.2157 | 0.2157 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0428 | 0.5321 | 0.5321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0292 | 0.3164 | 0.5946 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0682 | 0.9368 | 1 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0229 | 0.2157 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0428 | 0.5321 | 0.5321 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0229 | 0.2157 | 0.2157 |
Toxoplasma gondii | cathepsin B | 0.0276 | 0.2897 | 0.5445 |
Echinococcus granulosus | cathepsin l1 | 0.0428 | 0.5321 | 0.5321 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.2303 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0276 | 0.2897 | 0.2897 |
Echinococcus multilocularis | cysteine protease | 0.0428 | 0.5321 | 0.5321 |
Echinococcus multilocularis | cathepsin L | 0.0229 | 0.2157 | 0.2157 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0276 | 0.2897 | 0.5445 |
Onchocerca volvulus | 0.0292 | 0.3164 | 0.5946 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0276 | 0.2897 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0292 | 0.3164 | 0.3164 |
Loa Loa (eye worm) | fibroinase | 0.0428 | 0.5321 | 0.5321 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Plasmodium vivax | vivapain-2 | 0.0428 | 0.5321 | 1 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0428 | 0.5321 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0682 | 0.9368 | 0.9368 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.3164 | 0.5946 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0276 | 0.2897 | 0.234 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0229 | 0.2157 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.4054 |
Toxoplasma gondii | cathepsin CPL | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0292 | 0.3164 | 0.3377 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0428 | 0.5321 | 0.5321 |
Echinococcus granulosus | cathepsin b | 0.0682 | 0.9368 | 0.9368 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0722 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0428 | 0.5321 | 0.568 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0292 | 0.3164 | 0.3164 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.3164 | 0.3164 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0428 | 0.5321 | 0.568 |
Brugia malayi | cathepsin L-like precursor | 0.0292 | 0.3164 | 0.3164 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0229 | 0.2157 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0428 | 0.5321 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0428 | 0.5321 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0682 | 0.9368 | 0.9368 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0428 | 0.5321 | 0.5321 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0135 | 0.0663 | 0.0663 |
Plasmodium vivax | unspecified product | 0.0135 | 0.0663 | 0.1247 |
Brugia malayi | Cathepsin L-like precursor | 0.0135 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0663 | 0.0663 |
Echinococcus granulosus | cathepsin L | 0.0229 | 0.2157 | 0.2157 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0229 | 0.2157 | 0.2157 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0428 | 0.5321 | 0.568 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0428 | 0.5321 | 0.5321 |
Echinococcus granulosus | cysteine protease | 0.0229 | 0.2157 | 0.2157 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0281 | 0.2985 | 0.3186 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0276 | 0.2897 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Echinococcus multilocularis | cathepsin b | 0.0682 | 0.9368 | 0.9368 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0428 | 0.5321 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0428 | 0.5321 | 0.5321 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0229 | 0.2157 | 0.2157 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0682 | 0.9368 | 0.9368 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0229 | 0.2157 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0722 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0682 | 0.9368 | 0.9368 |
Brugia malayi | Cathepsin L-like precursor | 0.0292 | 0.3164 | 0.3164 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0276 | 0.2897 | 0.2897 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0281 | 0.2985 | 0.2616 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0428 | 0.5321 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0428 | 0.5321 | 0.5321 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0428 | 0.5321 | 0.5321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.3164 | 0.3164 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0229 | 0.2157 | 0.4054 |
Echinococcus granulosus | cathepsin l1 | 0.0292 | 0.3164 | 0.3164 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0663 | 0.0663 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0682 | 0.9368 | 0.9368 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.3164 | 0.3164 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Plasmodium vivax | vivapain-1 | 0.0229 | 0.2157 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0292 | 0.3164 | 0.3164 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0722 | 1 | 1 |
Schistosoma mansoni | cathepsin s | 0.0135 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 0.9368 | 0.9368 |
Loa Loa (eye worm) | ctsf protein | 0.0428 | 0.5321 | 0.5321 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0276 | 0.2897 | 1 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0663 | 0.0663 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0229 | 0.2157 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0428 | 0.5321 | 0.5321 |
Brugia malayi | Cathepsin L-like precursor | 0.0428 | 0.5321 | 0.5321 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0229 | 0.2157 | 0.2303 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0428 | 0.5321 | 0.5321 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0135 | 0.0663 | 0.0708 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.5321 | 0.5321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0135 | 0.0663 | 0.0663 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0722 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0229 | 0.2157 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0229 | 0.2157 | 0.2157 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0682 | 0.9368 | 0.9368 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0428 | 0.5321 | 0.568 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0292 | 0.3164 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0276 | 0.2897 | 0.3093 |
Onchocerca volvulus | 0.0428 | 0.5321 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0428 | 0.5321 | 0.5321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0229 | 0.2157 | 0.2157 |
Loa Loa (eye worm) | cysteine protease | 0.0428 | 0.5321 | 0.5321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0428 | 0.5321 | 0.568 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0428 | 0.5321 | 0.5321 |
Entamoeba histolytica | cysteine protease, putative | 0.0229 | 0.2157 | 0.4054 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0281 | 0.2985 | 0.3186 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0135 | 0.0663 | 0.0663 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0229 | 0.2157 | 0.2303 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0135 | 0.0663 | 0.0708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0428 | 0.5321 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0428 | 0.5321 | 1 |
Echinococcus granulosus | cathepsin b | 0.0682 | 0.9368 | 0.9368 |
Trypanosoma cruzi | cysteine protease, putative | 0.0229 | 0.2157 | 0.2303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (functional) | = 0.321 mM kg-1 | Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. | ChEMBL. | 2913310 |
LD50 (functional) | = 0.321 mM kg-1 | Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. | ChEMBL. | 2913310 |
logD (ADMET) | = -0.86 | Partition coefficient (logD7.6) | ChEMBL. | 2913310 |
pKa | = 7.97 | Dissociation constant (pKa) (in 0.1 M phosphate buffer) | ChEMBL. | 2913310 |
Survivors (functional) | = 0 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/8 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Survivors (functional) | = 0 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/16 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Survivors (functional) | = 3 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/4 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.