Detailed information for compound 254401

Basic information

Technical information
  • TDR Targets ID: 254401
  • Name: triethyl-[12-(triethylazaniumyl)dodecyl]azani um dibromide
  • MW: 530.507 | Formula: C24H54Br2N2
  • H donors: 0 H acceptors: 0 LogP: 9.15 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[N+](CCCCCCCCCCCC[N+](CC)(CC)CC)(CC)CC.[Br-].[Br-]
  • InChi: 1S/C24H54N2.2BrH/c1-7-25(8-2,9-3)23-21-19-17-15-13-14-16-18-20-22-24-26(10-4,11-5)12-6;;/h7-24H2,1-6H3;2*1H/q+2;;/p-2
  • InChiKey: ZPGQJMZSOYWJQD-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • triethyl-[12-(triethylammonio)dodecyl]ammonium dibromide
  • triethyl-(12-triethylazaniumyldodecyl)azanium dibromide
  • triethyl-(12-triethylammoniododecyl)ammonium dibromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni steroid hormone receptor ad4bp 0.147164 0.86651 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Trichomonas vaginalis aldo/keto reductase, putative 0.0122131 0.0631495 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.00189866 0.00174773 0.00201698
Entamoeba histolytica alcohol dehydrogenase, putative 0.00385811 0.0134123 0.205285
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00189866 0.00174773 0.00201698
Brugia malayi hypothetical protein 0.00424724 0.0157288 0.0157288
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.147164 0.86651 0.86651
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Schistosoma mansoni cytochrome P450 reductase 0.00248466 0.00523617 0.00604282
Brugia malayi Peroxidasin 0.00280235 0.00712739 0.00712739
Echinococcus granulosus Dipeptidyl peptidase 9 0.00539695 0.022573 0.0260505
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.00385811 0.0134123 0.205285
Schistosoma mansoni hypothetical protein 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis sex peptide receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus voltage gated potassium channel subunit 0.00385811 0.0134123 0.0154785
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis G protein coupled receptor 139 0.0129889 0.0677678 0.0782077
Trypanosoma cruzi p450 reductase, putative 0.00248466 0.00523617 0.0617269
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.016369 0.0878893 0.101429
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00189866 0.00174773 0.00201698
Toxoplasma gondii hypothetical protein 0.00428096 0.0159295 0.245506
Schistosoma mansoni neuropeptide receptor 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear hormone receptor 0.0694195 0.403698 0.403698
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Trypanosoma brucei aldo/keto reductase, putative 0.00385811 0.0134123 0.16976
Loa Loa (eye worm) latrophilin receptor protein 2 0.013164 0.0688101 0.0688101
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00189866 0.00174773 0.00174773
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.00539695 0.022573 0.290803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.147164 0.86651 1
Echinococcus granulosus allatostatin A receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.00248466 0.00523617 0.00604282
Brugia malayi Dopamine receptor protein 1 0.00189866 0.00174773 0.00174773
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear receptor RXR 0.0777445 0.453257 0.453257
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Echinococcus granulosus Nuclear hormone receptor HR96 0.0694195 0.403698 0.46589
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.147164 0.86651 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear hormone receptor family member nhr-6 0.0694195 0.403698 0.403698
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0122131 0.0631495 0.0631495
Loa Loa (eye worm) FAD binding domain-containing protein 0.00248466 0.00523617 0.00523617
Onchocerca volvulus 0.00280235 0.00712739 0.00622097
Echinococcus granulosus biogenic amine 5HT receptor 0.00189866 0.00174773 0.00201698
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0122131 0.0631495 0.0631495
Brugia malayi neuropeptide F receptor 0.00189866 0.00174773 0.00174773
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Brugia malayi Melatonin receptor type 1A 0.00189866 0.00174773 0.00174773
Brugia malayi tailless protein 0.0694195 0.403698 0.403698
Schistosoma mansoni hypothetical protein 0.00189866 0.00174773 0.00201698
Echinococcus granulosus thyroid hormone receptor alpha 0.0694195 0.403698 0.46589
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.016369 0.0878893 0.101429
Schistosoma mansoni peroxidasin 0.00280235 0.00712739 0.0082254
Echinococcus granulosus nuclear receptor nhr 48 0.0694195 0.403698 0.46589
Trichomonas vaginalis aldo/keto reductase, putative 0.0122131 0.0631495 1
Loa Loa (eye worm) oxidoreductase 0.0122131 0.0631495 0.0631495
Mycobacterium ulcerans hypothetical protein 0.00385811 0.0134123 0.141179
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0235199 0.130459 0.150556
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0122131 0.0631495 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00189866 0.00174773 0.00174773
Leishmania major prostaglandin f synthase, putative 0.0122131 0.0631495 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0235199 0.130459 0.150556
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Onchocerca volvulus Chorion peroxidase homolog 0.00280235 0.00712739 0.00622097
Loa Loa (eye worm) TYRA-2 protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Brugia malayi Nuclear hormone receptor-like 1 0.147164 0.86651 0.86651
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00189866 0.00174773 0.00174773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.147164 0.86651 0.86651
Trichomonas vaginalis conserved hypothetical protein 0.00198481 0.00226059 0.0270994
Toxoplasma gondii transporter, cation channel family protein 0.00513771 0.0210297 0.326998
Echinococcus multilocularis aldehyde reductase 0.00835501 0.0401823 0.0463726
Brugia malayi Nuclear hormone receptor-like 1 0.0777445 0.453257 0.453257
Brugia malayi Dynamin 0.00182998 0.00133886 0.00133886
Echinococcus multilocularis voltage dependent calcium channel 0.0235199 0.130459 0.150556
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus granulosus GPCR family 2 0.013164 0.0688101 0.0794107
Trichomonas vaginalis aldo/keto reductase, putative 0.0122131 0.0631495 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.147164 0.86651 0.86651
Brugia malayi Dynamin central region family protein 0.00169991 0.000564578 0.000564578
Echinococcus granulosus neuropeptide receptor A26 0.00189866 0.00174773 0.00201698
Schistosoma mansoni peroxidasin 0.00280235 0.00712739 0.0082254
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Brugia malayi G-protein coupled receptor 0.00189866 0.00174773 0.00174773
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) hypothetical protein 0.0235199 0.130459 0.130459
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus ecdysone induced protein 78C 0.147164 0.86651 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus 7tm_1 domain containing protein 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trypanosoma cruzi aldo/keto reductase, putative 0.00385811 0.0134123 0.16976
Echinococcus multilocularis Dipeptidyl peptidase 9 0.00539695 0.022573 0.0260505
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) nuclear hormone receptor 0.0694195 0.403698 0.403698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni biogenic amine receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Giardia lamblia Aldose reductase 0.0122131 0.0631495 1
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.0777445 0.453257 0.453257
Loa Loa (eye worm) prolyl oligopeptidase 0.016369 0.0878893 0.0878893
Brugia malayi AKH receptor 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Brugia malayi Serine carboxypeptidase S28 family protein 0.00198481 0.00226059 0.00226059
Echinococcus granulosus sodium channel protein 0.00475392 0.0187451 0.0216329
Onchocerca volvulus Peroxidase homolog 0.00280235 0.00712739 0.00622097
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Brugia malayi follicle stimulating hormone receptor 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis sodium channel protein 0.0140293 0.0739615 0.0853556
Loa Loa (eye worm) G-protein coupled receptor 0.00189866 0.00174773 0.00174773
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0235199 0.130459 0.150556
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) melatonin receptor type 1A 0.00189866 0.00174773 0.00174773
Schistosoma mansoni opsin-like receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus Nuclear hormone receptor HR96 0.0694195 0.403698 0.46589
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Schistosoma mansoni retinoid-x-receptor (RXR) 0.147164 0.86651 1
Echinococcus granulosus neuropeptide receptor 0.0129889 0.0677678 0.0782077
Brugia malayi Tachykinin-like peptides receptor 99D 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis neuropeptide s receptor 0.00189866 0.00174773 0.00201698
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni aldo-keto reductase 0.0122131 0.0631495 0.072878
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0122131 0.0631495 0.0631495
Loa Loa (eye worm) hypothetical protein 0.0777445 0.453257 0.453257
Onchocerca volvulus Peroxidasin homolog 0.00280235 0.00712739 0.00622097
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis neuropeptide Y receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear receptor NHR-67 0.0694195 0.403698 0.403698
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.00198481 0.00226059 0.0224099
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0235199 0.130459 0.150556
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.147164 0.86651 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013164 0.0688101 0.0794107
Brugia malayi G protein-coupled receptor 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.147164 0.86651 0.86651
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi larval opioid receptor 0.00189866 0.00174773 0.00174773
Schistosoma mansoni coup transcription factor 0.147164 0.86651 1
Schistosoma mansoni neuropeptide receptor 0.0129889 0.0677678 0.0782077
Onchocerca volvulus 0.00280235 0.00712739 0.00622097
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis aldo keto reductase 0.0122131 0.0631495 0.072878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni nuclear hormone receptor 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Brugia malayi Nuclear hormone receptor family member nhr-49 0.147164 0.86651 0.86651
Brugia malayi Latrophilin receptor protein 2 0.013164 0.0688101 0.0688101
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0235199 0.130459 0.150556
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.147164 0.86651 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0416047 0.238117 0.238117
Plasmodium falciparum aldo-keto reductase, putative 0.00385811 0.0134123 1
Entamoeba histolytica aldose reductase, putative 0.0122131 0.0631495 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) steroid hormone receptor 0.147164 0.86651 0.86651
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.147164 0.86651 0.86651
Echinococcus granulosus neuropeptide s receptor 0.00189866 0.00174773 0.00201698
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013164 0.0688101 0.0688101
Schistosoma mansoni pol-related 0.0122131 0.0631495 0.072878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0694195 0.403698 0.403698
Echinococcus granulosus neuropeptide receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni opsin-like receptor 0.00189866 0.00174773 0.00201698
Mycobacterium leprae Conserved hypothetical protein 0.00835501 0.0401823 0.538228
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00189866 0.00174773 0.00174773
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.00539695 0.022573 0.290803
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) animal heme peroxidase 0.00280235 0.00712739 0.00712739
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus g-protein coupled receptor 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis aldo-keto reductase, putative 0.00385811 0.0134123 0.205285
Echinococcus multilocularis aldo keto reductase 0.0122131 0.0631495 0.072878
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.00198481 0.00226059 0.0224099
Schistosoma mansoni biogenic amine receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Loa Loa (eye worm) voltage-dependent calcium channel 0.00513771 0.0210297 0.0210297
Echinococcus multilocularis G-protein coupled receptor, putative 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis aldo keto reductase 0.0122131 0.0631495 0.072878
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0694195 0.403698 0.46589
Schistosoma mansoni neuropeptide receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.00385811 0.0134123 0.0134123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.147164 0.86651 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0777445 0.453257 0.523083
Loa Loa (eye worm) neuropeptide F receptor 0.00189866 0.00174773 0.00174773
Echinococcus granulosus dro:myosuppressin receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0235199 0.130459 0.150556
Brugia malayi Nuclear hormone receptor family member nhr-31 0.147164 0.86651 0.86651
Brugia malayi ecdysone receptor 0.0694195 0.403698 0.403698
Echinococcus granulosus fmrfamide receptor 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0694195 0.403698 0.403698
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Nuclear hormone receptor E75 0.0694195 0.403698 0.403698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni dynamin 0.00182998 0.00133886 0.00154512
Brugia malayi steroid hormone receptor 0.147164 0.86651 0.86651
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.00198481 0.00226059 0.00260885
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus tm gpcr rhodopsin 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear receptor NHR-88 0.147164 0.86651 0.86651
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.147164 0.86651 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis g protein coupled receptor 0.00189866 0.00174773 0.00201698
Onchocerca volvulus 0.00385811 0.0134123 0.0134888
Schistosoma mansoni neuropeptide f receptor 76f 0.00189866 0.00174773 0.00201698
Echinococcus granulosus neuropeptides capa receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus aldehyde reductase 0.00835501 0.0401823 0.0463726
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00189866 0.00174773 0.00201698
Brugia malayi Calcitonin receptor-like protein seb-1 0.0416047 0.238117 0.238117
Schistosoma mansoni potassium channel beta 0.00385811 0.0134123 0.0154785
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00189866 0.00174773 0.00201698
Brugia malayi FAD binding domain containing protein 0.00248466 0.00523617 0.00523617
Brugia malayi Serotonin receptor 0.00189866 0.00174773 0.00174773
Schistosoma mansoni voltage-gated cation channel 0.0235199 0.130459 0.150556
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0235199 0.130459 0.150556
Loa Loa (eye worm) oxidoreductase 0.0122131 0.0631495 0.0631495
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Brugia malayi Nuclear hormone receptor family member nhr-19 0.147164 0.86651 0.86651
Echinococcus granulosus 7TM GPCR rhodopsin 0.00189866 0.00174773 0.00201698
Onchocerca volvulus Peroxidase homolog 0.00280235 0.00712739 0.00622097
Echinococcus granulosus hypothetical protein 0.00189866 0.00174773 0.00201698
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni nuclear receptor nhr-48 0.0694195 0.403698 0.46589
Schistosoma mansoni amine GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi Animal haem peroxidase family protein 0.00280235 0.00712739 0.00712739
Brugia malayi Dopamine receptor 0.00189866 0.00174773 0.00174773
Entamoeba histolytica aldose reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis g-protein coupled receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0777445 0.453257 0.523083
Schistosoma mansoni myosin xvIII 0.00189866 0.00174773 0.00201698
Schistosoma mansoni Tr4/Tr2 (homologue) 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Loa Loa (eye worm) neuropeptide F receptor 0.00189866 0.00174773 0.00174773
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.00385811 0.0134123 0.0154785
Brugia malayi orphan nuclear receptor NR2E1 0.0694195 0.403698 0.403698
Brugia malayi nuclear receptor NHR-88 0.0694195 0.403698 0.403698
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) blistered cuticle protein 3 0.00280235 0.00712739 0.00712739
Schistosoma mansoni alpha-1 adrenergic receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Schistosoma mansoni dynamin 0.00169991 0.000564578 0.000651554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.147164 0.86651 0.86651
Schistosoma mansoni aldo-keto reductase 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.00182998 0.00133886 0.00133886
Loa Loa (eye worm) animal heme peroxidase 0.00280235 0.00712739 0.00712739
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Schistosoma mansoni hypothetical protein 0.013164 0.0688101 0.0794107
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00189866 0.00174773 0.00201698
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Plasmodium vivax flavodoxin domain containing protein 0.00227952 0.00401499 0.268562
Echinococcus multilocularis FTZ F1 alpha 0.147164 0.86651 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122131 0.0631495 1
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.00198481 0.00226059 0.00260885
Echinococcus granulosus alpha 1A adrenergic receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.169588 1 1
Echinococcus multilocularis dynamin 1 0.00182998 0.00133886 0.00154512
Loa Loa (eye worm) oxidoreductase 0.0122131 0.0631495 0.0631495
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Echinococcus multilocularis neuropeptides capa receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0694195 0.403698 0.46589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00189866 0.00174773 0.00201698
Brugia malayi GnHR receptor homolog 0.00189866 0.00174773 0.00174773
Echinococcus granulosus neuropeptides capa receptor 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear hormone receptor family member odr-7 0.0694195 0.403698 0.403698
Schistosoma mansoni amine GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi nuclear receptor RXR 0.0694195 0.403698 0.403698
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00189866 0.00174773 0.00201698
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00248466 0.00523617 0.0617269
Brugia malayi Serine protease Z688.6 precursor 0.00198481 0.00226059 0.00226059
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus aldo keto reductase family 1, member B4 0.00385811 0.0134123 0.0154785
Schistosoma mansoni hypothetical protein 0.0284407 0.159752 0.184363
Plasmodium falciparum aldehyde reductase, putative 0.00385811 0.0134123 1
Brugia malayi G protein-coupled receptor F59B2.13 0.00189866 0.00174773 0.00174773
Onchocerca volvulus 0.147164 0.86651 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0694195 0.403698 0.46481
Echinococcus granulosus FTZ F1 alpha 0.147164 0.86651 1
Schistosoma mansoni RAR-like nuclear receptor 0.147164 0.86651 1
Giardia lamblia Thymus-specific serine protease precursor 0.00198481 0.00226059 0.0270994
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.00539695 0.022573 0.351657
Echinococcus multilocularis fmrfamide receptor 0.00189866 0.00174773 0.00201698
Leishmania major aldo-keto reductase-like protein 0.0122131 0.0631495 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0122131 0.0631495 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Brugia malayi flavodoxin family protein 0.00248466 0.00523617 0.00523617
Brugia malayi hypothetical protein 0.0694195 0.403698 0.403698
Trichomonas vaginalis alcohol dehydrogenase, putative 0.00385811 0.0134123 0.205285
Loa Loa (eye worm) hypothetical protein 0.00248466 0.00523617 0.00523617
Giardia lamblia Nitric oxide synthase, inducible 0.00227952 0.00401499 0.0551317
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.147164 0.86651 0.86651
Loa Loa (eye worm) hypothetical protein 0.0122131 0.0631495 0.0631495
Brugia malayi sulfakinin receptor protein 0.00189866 0.00174773 0.00174773
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00198481 0.00226059 0.0270994
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis ecdysone induced protein 78C 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.00428096 0.0159295 0.0159295
Trichomonas vaginalis aldo-keto reductase, putative 0.00385811 0.0134123 0.205285
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Loa Loa (eye worm) hypothetical protein 0.0777445 0.453257 0.453257
Onchocerca volvulus 0.00280235 0.00712739 0.00622097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Brugia malayi Nuclear hormone receptor-like 1 0.0777445 0.453257 0.453257
Brugia malayi Animal haem peroxidase family protein 0.00280235 0.00712739 0.00712739
Echinococcus granulosus voltage dependent calcium channel 0.0235199 0.130459 0.150556
Brugia malayi Nuclear hormone receptor family member nhr-14 0.147164 0.86651 0.86651
Echinococcus multilocularis neuropeptide FF receptor 2 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0694195 0.403698 0.46589
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00424724 0.0157288 0.0157288
Loa Loa (eye worm) hypothetical protein 0.00198481 0.00226059 0.00226059
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Toxoplasma gondii serine carboxypeptidase s28 protein 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) hypothetical protein 0.00198481 0.00226059 0.00226059
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0290533 0.163399 0.188571
Echinococcus granulosus dynamin 1 protein 0.00169991 0.000564578 0.000651554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.147164 0.86651 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis dro:myosuppressin receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0144131 0.0762462 1
Brugia malayi Animal haem peroxidase family protein 0.00280235 0.00712739 0.00712739
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Echinococcus granulosus dynamin 1 0.00182998 0.00133886 0.00154512
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.147164 0.86651 1
Echinococcus granulosus voltage dependent calcium channel 0.00513771 0.0210297 0.0242695
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Schistosoma mansoni nuclear hormone receptor 0.0694195 0.403698 0.46589
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Giardia lamblia Hypothetical protein 0.00227952 0.00401499 0.0551317
Brugia malayi G-protein coupled receptor 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.016369 0.0878893 0.101429
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.169588 1 1
Onchocerca volvulus Bile acid receptor homolog 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) animal heme peroxidase 0.00280235 0.00712739 0.00712739
Brugia malayi putative neuropeptide receptor 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.00539695 0.022573 0.290803
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00189866 0.00174773 0.00174773
Brugia malayi putative neuropeptide receptor NPR1 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.013164 0.0688101 0.0688101
Loa Loa (eye worm) hypothetical protein 0.00198481 0.00226059 0.00226059
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Brugia malayi Blistered cuticle protein 3 0.00280235 0.00712739 0.00712739
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis orexin receptor type 2 0.00189866 0.00174773 0.00201698
Brugia malayi prolyl oligopeptidase family protein 0.00539695 0.022573 0.022573
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.00385811 0.0134123 1
Schistosoma mansoni nuclear hormone receptor 0.0694195 0.403698 0.46589
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.00248466 0.00523617 0.00604282
Loa Loa (eye worm) DR-78 0.0694195 0.403698 0.403698
Schistosoma mansoni histamine h1 receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0235199 0.130459 0.150556
Brugia malayi photoreceptor-specific nuclear receptor 0.147164 0.86651 0.86651
Toxoplasma gondii aldose reductase, putative 0.0122131 0.0631495 1
Schistosoma mansoni amine GPCR 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.00248466 0.00523617 0.0617269
Leishmania major p450 reductase, putative 0.00248466 0.00523617 0.074644
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.147164 0.86651 0.86651
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis nuclear receptor nhr 48 0.0694195 0.403698 0.46589
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.00385811 0.0134123 0.205285
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00189866 0.00174773 0.00174773
Brugia malayi Nuclear hormone receptor family member nhr-40 0.147164 0.86651 0.86651
Brugia malayi nuclear hormone receptor 0.147164 0.86651 0.86651
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0694195 0.403698 0.46589
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Trichomonas vaginalis conserved hypothetical protein 0.00385811 0.0134123 0.205285
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.00539695 0.022573 0.351657
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Loa Loa (eye worm) DRP-1 protein 0.00169991 0.000564578 0.000564578
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0694195 0.403698 0.46589
Echinococcus multilocularis neuropeptide receptor 0.0129889 0.0677678 0.0782077
Echinococcus multilocularis fmrfamide receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni zinc finger protein 0.0694195 0.403698 0.46589
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Echinococcus granulosus sex peptide receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Nuclear hormone receptor E75 0.0694195 0.403698 0.403698
Echinococcus granulosus rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Brugia malayi latrophilin 2 splice variant baaae 0.0284407 0.159752 0.159752
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Brugia malayi Nuclear hormone receptor family member nhr-41 0.147164 0.86651 0.86651
Echinococcus multilocularis allatostatin A receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.00198481 0.00226059 0.00260885
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.00248466 0.00523617 0.0617269
Brugia malayi ORL1-like opioid receptor 0.00189866 0.00174773 0.00174773
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.016369 0.0878893 0.0996131
Echinococcus granulosus NADPH cytochrome P450 reductase 0.00248466 0.00523617 0.00604282
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.147164 0.86651 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.147164 0.86651 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.00198481 0.00226059 0.0270994
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) oxidoreductase 0.0122131 0.0631495 0.0631495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus orexin receptor type 2 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus granulosus tachykinin peptides receptor 99D 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.147164 0.86651 1
Trichomonas vaginalis sulfite reductase, putative 0.00248466 0.00523617 0.074644
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00189866 0.00174773 0.00201698
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0122131 0.0631495 0.0631495
Echinococcus granulosus neuropeptide Y receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni hypothetical protein 0.013164 0.0688101 0.0794107
Giardia lamblia Aldose reductase 0.0122131 0.0631495 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Trichomonas vaginalis conserved hypothetical protein 0.00198481 0.00226059 0.0270994
Brugia malayi Dopamine receptor protein 2 0.00189866 0.00174773 0.00174773
Echinococcus granulosus g protein coupled receptor 0.00189866 0.00174773 0.00201698
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Echinococcus multilocularis somatostatin receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis neuropeptide receptor A26 0.00189866 0.00174773 0.00201698
Schistosoma mansoni biogenic amine (5HT) receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni neuropeptide receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus G protein coupled receptor 139 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Brugia malayi prolyl oligopeptidase family protein 0.016369 0.0878893 0.0878893
Echinococcus multilocularis serotonin receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.00428096 0.0159295 0.0159295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.147164 0.86651 0.86651
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00189866 0.00174773 0.00174773
Schistosoma mansoni neuropeptide F-like receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0777445 0.453257 0.523083
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.00539695 0.022573 0.0260505
Brugia malayi Serine protease Z688.6 precursor 0.00198481 0.00226059 0.00226059
Leishmania major cytochrome P450 reductase, putative 0.00227952 0.00401499 0.0551317
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Entamoeba histolytica alcohol dehydrogenase, putative 0.00385811 0.0134123 0.205285
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Loa Loa (eye worm) nuclear receptor NHR-67 0.0694195 0.403698 0.403698
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.00248466 0.00523617 0.363612
Echinococcus multilocularis serotonin receptor 0.00189866 0.00174773 0.00201698
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00189866 0.00174773 0.00174773
Echinococcus granulosus peptide allatostatin:somatostatin 0.00189866 0.00174773 0.00201698
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis dynamin 1 protein 0.00169991 0.000564578 0.000651554
Onchocerca volvulus Dual oxidase homolog 0.00280235 0.00712739 0.00622097
Echinococcus granulosus somatostatin receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0694195 0.403698 0.46589
Echinococcus multilocularis neuropeptide Y receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus tm gpcr rhodopsin 0.00189866 0.00174773 0.00201698
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.00248466 0.00523617 0.0617269
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Animal haem peroxidase family protein 0.00280235 0.00712739 0.00712739
Schistosoma mansoni adenoreceptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus peroxidasin 0.00280235 0.00712739 0.0082254
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013164 0.0688101 0.0794107
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0235199 0.130459 0.150556
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0777445 0.453257 0.523083
Leishmania major calcium channel protein, putative,ion transporter, putative 0.00475392 0.0187451 0.290493
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.00198481 0.00226059 0.0270994
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.00227952 0.00401499 0.0551317
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.00248466 0.00523617 0.0617269
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0694195 0.403698 0.46589
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00248466 0.00523617 0.0617269
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0694195 0.403698 0.46589
Onchocerca volvulus Protein ultraspiracle homolog 0.147164 0.86651 1
Onchocerca volvulus 0.0694195 0.403698 0.46481
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.147164 0.86651 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.00198481 0.00226059 0.0270994
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0290533 0.163399 0.188571
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Schistosoma mansoni hypothetical protein 0.00189866 0.00174773 0.00201698
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis voltage dependent calcium channel 0.0235199 0.130459 0.150556
Loa Loa (eye worm) hypothetical protein 0.0777445 0.453257 0.453257
Loa Loa (eye worm) hypothetical protein 0.0777445 0.453257 0.453257
Schistosoma mansoni amine GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni nuclear receptor 0.0694195 0.403698 0.46589
Loa Loa (eye worm) hypothetical protein 0.00513771 0.0210297 0.0210297
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Echinococcus multilocularis neuropeptide receptor 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.147164 0.86651 0.86651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) oxidoreductase 0.0122131 0.0631495 0.0631495
Brugia malayi Dynamin 0.00182998 0.00133886 0.00133886
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0290533 0.163399 0.188571
Schistosoma mansoni hypothetical protein 0.013164 0.0688101 0.0794107
Mycobacterium ulcerans oxidoreductase 0.0122131 0.0631495 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0122131 0.0631495 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00189866 0.00174773 0.00201698
Trypanosoma brucei aldo-keto reductase, putative 0.0122131 0.0631495 0.826951
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0144131 0.0762462 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0777445 0.453257 0.453257
Brugia malayi hypothetical protein 0.0694195 0.403698 0.403698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.147164 0.86651 0.86651
Trypanosoma cruzi cytochrome P450 reductase, putative 0.00248466 0.00523617 0.0617269
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.141147 0.830693 0.958665
Onchocerca volvulus 0.00198481 0.00226059 0.000593066
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Toxoplasma gondii aldo-keto reductase 0.00385811 0.0134123 0.205285
Echinococcus multilocularis g protein coupled receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Nuclear hormone receptor family member nhr-19 0.147164 0.86651 0.86651
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Brugia malayi ecdysteroid receptor 0.147164 0.86651 0.86651
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Echinococcus granulosus g protein coupled receptor 0.00189866 0.00174773 0.00201698
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni amine GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis dynamin 0.00169991 0.000564578 0.000651554
Plasmodium falciparum nitric oxide synthase, putative 0.00248466 0.00523617 0.363612
Echinococcus granulosus neuropeptide Y receptor 0.00189866 0.00174773 0.00201698
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0235199 0.130459 0.130459
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0694195 0.403698 0.46589
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0140293 0.0739615 0.0853556
Trypanosoma brucei prostaglandin f synthase 0.0122131 0.0631495 0.826951
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.00198481 0.00226059 0.00226059
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.147164 0.86651 1
Brugia malayi hypothetical protein 0.00280235 0.00712739 0.00712739
Echinococcus multilocularis neuropeptides capa receptor 0.00189866 0.00174773 0.00201698
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus dynamin 0.00169991 0.000564578 0.000651554
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Brugia malayi Nuclear hormone receptor family member nhr-1 0.147164 0.86651 0.86651
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.00539695 0.022573 0.290803
Echinococcus granulosus biogenic amine 5HT receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Echinococcus multilocularis GPCR, family 2 0.013164 0.0688101 0.0794107
Brugia malayi Serotonin receptor 0.00189866 0.00174773 0.00174773
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.00248466 0.00523617 0.00604282
Echinococcus granulosus serotonin receptor 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis aldo-keto reductase, putative 0.00385811 0.0134123 0.205285
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.00198481 0.00226059 0.0270994
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0122131 0.0631495 0.072878
Schistosoma mansoni dynamin 0.00182998 0.00133886 0.00154512
Echinococcus granulosus aldo keto reductase 0.0122131 0.0631495 0.072878
Echinococcus granulosus neuropeptide FF receptor 2 0.00189866 0.00174773 0.00201698
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.00198481 0.00226059 0.0224099
Brugia malayi Animal haem peroxidase family protein 0.00280235 0.00712739 0.00712739
Echinococcus multilocularis rhodopsin orphan GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.147164 0.86651 1
Schistosoma mansoni growth hormone secretagogue receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus retinoic acid receptor rxr beta a 0.147164 0.86651 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0122131 0.0631495 1
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Loa Loa (eye worm) G-protein coupled receptor 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Onchocerca volvulus 0.0122131 0.0631495 0.0710042
Trichomonas vaginalis aldo-keto reductase, putative 0.0122131 0.0631495 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Echinococcus granulosus g protein coupled receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00189866 0.00174773 0.00201698
Brugia malayi glutamate-cysteine ligase modifier subunit 0.00385811 0.0134123 0.0134123
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00189866 0.00174773 0.00201698
Schistosoma mansoni thyroid hormone receptor 0.147164 0.86651 1
Brugia malayi hypothetical protein 0.00189866 0.00174773 0.00174773
Trypanosoma cruzi aldo-keto reductase 0.0122131 0.0631495 0.826951
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Onchocerca volvulus 0.0694195 0.403698 0.46481
Echinococcus multilocularis peroxidasin 0.00280235 0.00712739 0.0082254
Entamoeba histolytica aldose reductase, putative 0.0122131 0.0631495 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) calcium channel 0.0235199 0.130459 0.130459
Schistosoma mansoni biogenic amine receptor 0.00189866 0.00174773 0.00201698
Brugia malayi neuropeptide F receptor 0.00189866 0.00174773 0.00174773
Schistosoma mansoni retinoic acid receptor RXR 0.147164 0.86651 1
Echinococcus multilocularis aldo keto reductase 0.0122131 0.0631495 0.072878
Brugia malayi Steroid receptor seven-up type 2 0.147164 0.86651 0.86651
Echinococcus multilocularis g protein coupled receptor 0.00189866 0.00174773 0.00201698
Echinococcus granulosus aldo keto reductase 0.0122131 0.0631495 0.072878
Plasmodium vivax aldehyde reductase, putative 0.00385811 0.0134123 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.147164 0.86651 1
Schistosoma mansoni nuclear receptor 0.0694195 0.403698 0.46589
Echinococcus granulosus hypothetical protein 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.0694195 0.403698 0.403698
Brugia malayi NADH-dependent xylose reductase 0.00385811 0.0134123 0.0134123
Brugia malayi conserved hypotetical protein 0.0694195 0.403698 0.403698
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00189866 0.00174773 0.00201698
Schistosoma mansoni hypothetical protein 0.00189866 0.00174773 0.00201698
Schistosoma mansoni neuropeptide F-like receptor 0.00189866 0.00174773 0.00201698
Onchocerca volvulus Peroxidasin homolog 0.00280235 0.00712739 0.00622097
Loa Loa (eye worm) hypothetical protein 0.00280235 0.00712739 0.00712739
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.00248466 0.00523617 0.074644
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00189866 0.00174773 0.00201698
Schistosoma mansoni thyroid hormone receptor 0.147164 0.86651 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0122131 0.0631495 0.826951
Brugia malayi RE15519p 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.0284407 0.159752 0.159752
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00189866 0.00174773 0.00201698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.147164 0.86651 0.86651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.147164 0.86651 0.86651
Loa Loa (eye worm) animal heme peroxidase 0.00280235 0.00712739 0.00712739
Brugia malayi hypothetical protein 0.0777445 0.453257 0.453257
Brugia malayi hypothetical protein 0.0777445 0.453257 0.453257
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0122131 0.0631495 0.072878
Schistosoma mansoni opsin-like receptor 0.00189866 0.00174773 0.00201698
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.00198481 0.00226059 0.0270994
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.00385811 0.0134123 0.205285
Giardia lamblia Serine peptidase, putative 0.00198481 0.00226059 0.0270994
Echinococcus multilocularis thyroid hormone receptor alpha 0.147164 0.86651 1
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Echinococcus granulosus aldo keto reductase 0.0122131 0.0631495 0.072878
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Loa Loa (eye worm) hypothetical protein 0.00189866 0.00174773 0.00174773
Schistosoma mansoni hypothetical protein 0.013164 0.0688101 0.0794107
Echinococcus granulosus tm gpcr rhodopsin 0.00189866 0.00174773 0.00201698
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0694195 0.403698 0.46481
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.141147 0.830693 0.958665
Chlamydia trachomatis sulfite reductase 0.00160507 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.045 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.045 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
MIC (functional) = 11 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 11 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 22 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066
MIC (functional) = 22 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 10669577

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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