Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 9 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Schistosoma mansoni | protein phosphatase 2C | 0.0014 | 0.0042 | 0.0041 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0768 | 0.0817 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.005 | 0.0521 | 0.0554 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.002 | 0.0127 | 0.0127 |
Brugia malayi | jmjC domain containing protein | 0.0051 | 0.0543 | 0.0543 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0759 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0759 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0296 | 0.3819 | 0.8286 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0296 | 0.3819 | 0.8286 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0051 | 0.0543 | 0.1178 |
Toxoplasma gondii | 5'-nucleotidase, C-terminal domain-containing protein | 0.0026 | 0.0204 | 0.0204 |
Brugia malayi | jmjC domain containing protein | 0.0014 | 0.0042 | 0.0042 |
Schistosoma mansoni | integrin beta subunit | 0.0192 | 0.2425 | 0.2424 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0014 | 0.0042 | 0.0091 |
Brugia malayi | Histone deacetylase family protein | 0.0075 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0042 | 0.0044 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0014 | 0.005 | 0.0108 |
Trypanosoma brucei | histone deacetylase 4 | 0.0075 | 0.0866 | 0.0828 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0075 | 0.0866 | 0.0828 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0326 | 0.4216 | 0.4216 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0759 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0759 | 1 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0011 | 0.0009 | 0.0019 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0014 | 0.0042 | 0.0091 |
Schistosoma mansoni | cpg binding protein | 0.0011 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0075 | 0.0866 | 0.092 |
Echinococcus granulosus | integrin alpha ps | 0.0208 | 0.2637 | 0.5722 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0075 | 0.0866 | 0.0866 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 0.3793 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0014 | 0.0042 | 0.0041 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.008 | 0.0932 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0768 | 0.0817 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0042 | 0.0044 |
Schistosoma mansoni | ATP-diphosphohydrolase 1 | 0.008 | 0.0932 | 0.0932 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0296 | 0.3819 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0014 | 0.0042 | 0.0041 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0052 | 0.0551 | 0.0551 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0052 | 0.0551 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0042 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.4546 | 0.4831 |
Plasmodium falciparum | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0759 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0075 | 0.0866 | 0.0866 |
Echinococcus multilocularis | integrin alpha ps | 0.01 | 0.1191 | 0.2584 |
Brugia malayi | jmjC domain containing protein | 0.0052 | 0.0551 | 0.0551 |
Brugia malayi | Kelch motif family protein | 0.005 | 0.0521 | 0.0521 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0075 | 0.0866 | 0.0866 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.008 | 0.0932 | 0.2022 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0014 | 0.0042 | 0.0044 |
Echinococcus multilocularis | phd:f box containing protein | 0.0014 | 0.0042 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1191 | 0.1266 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0075 | 0.0866 | 0.0866 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0063 | 0.0697 | 0.0696 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0075 | 0.0866 | 0.0866 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0014 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0521 | 0.0554 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0296 | 0.3819 | 0.8286 |
Echinococcus granulosus | integrin beta 2 | 0.0241 | 0.3087 | 0.6696 |
Schistosoma mansoni | phd/f-box containing protein | 0.0014 | 0.0042 | 0.0041 |
Loa Loa (eye worm) | histone deacetylase | 0.0075 | 0.0866 | 0.092 |
Giardia lamblia | Hypothetical protein | 0.0026 | 0.0202 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Brugia malayi | jmjC domain containing protein | 0.0014 | 0.0042 | 0.0042 |
Schistosoma mansoni | integrin alpha-ps | 0.0208 | 0.2637 | 0.2637 |
Onchocerca volvulus | 0.0011 | 0 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.0011 | 0.0009 | 0.0008 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0296 | 0.3819 | 0.3819 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0759 | 1 | 1 |
Plasmodium falciparum | apyrase, putative | 0.008 | 0.0932 | 0.0894 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Loa Loa (eye worm) | integrin beta-2 | 0.0326 | 0.4216 | 0.4479 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0759 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0208 | 0.2637 | 0.5722 |
Schistosoma mansoni | integrin alpha | 0.0464 | 0.6056 | 0.6055 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0052 | 0.0551 | 0.0586 |
Schistosoma mansoni | integrin alpha-ps | 0.0108 | 0.1306 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.4724 | 0.502 |
Leishmania major | dihydroorotate dehydrogenase | 0.0759 | 1 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.01 | 0.1191 | 0.2584 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0051 | 0.0543 | 0.1178 |
Schistosoma mansoni | jumonji domain containing protein | 0.0051 | 0.0543 | 0.0543 |
Plasmodium falciparum | histone deacetylase 2 | 0.0075 | 0.0866 | 0.0828 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0014 | 0.0042 | 0.0041 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0296 | 0.3819 | 0.8286 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0014 | 0.0042 | 0.0091 |
Echinococcus granulosus | histone deacetylase 7 | 0.0075 | 0.0866 | 0.1879 |
Trypanosoma brucei | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Toxoplasma gondii | 5'-nucleotidase, C-terminal domain-containing protein | 0.0063 | 0.0697 | 0.0697 |
Echinococcus multilocularis | integrin beta 2 | 0.0241 | 0.3087 | 0.6696 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.008 | 0.0932 | 0.2022 |
Echinococcus multilocularis | dnaJ subfamily B | 0.015 | 0.1866 | 0.4049 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.3278 | 0.3483 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0075 | 0.0866 | 0.1879 |
Echinococcus multilocularis | integrin alpha ps | 0.0208 | 0.2637 | 0.5722 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0464 | 0.6056 | 0.6056 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0022 | 0.0158 | 0.0158 |
Brugia malayi | jmjC domain containing protein | 0.0014 | 0.0042 | 0.0042 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0052 | 0.0551 | 0.0551 |
Echinococcus granulosus | integrin alpha 3 | 0.0355 | 0.4609 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0759 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0014 | 0.0042 | 0.0042 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0347 | 0.4493 | 0.4493 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0759 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0347 | 0.4493 | 0.9748 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0014 | 0.0042 | 0.0042 |
Echinococcus granulosus | dnaJ subfamily B | 0.015 | 0.1866 | 0.4049 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0014 | 0.0042 | 0.0091 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.008 | 0.0932 | 0.2022 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0759 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0715 | 0.9411 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0014 | 0.005 | 0.0108 |
Echinococcus multilocularis | integrin alpha 3 | 0.0355 | 0.4609 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0347 | 0.4493 | 0.9748 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0014 | 0.0042 | 0.0091 |
Echinococcus multilocularis | histone deacetylase | 0.0075 | 0.0866 | 0.1879 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0075 | 0.0866 | 0.0828 |
Echinococcus granulosus | histone deacetylase | 0.0075 | 0.0866 | 0.1879 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0051 | 0.0543 | 0.1178 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0011 | 0 | 0.0001 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0014 | 0.0042 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.1866 | 0.1866 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Plasmodium vivax | histone deacetylase, putative | 0.0075 | 0.0866 | 0.0828 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.1191 | 0.1191 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0759 | 1 | 1 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0062 | 0.0694 | 0.0694 |
Echinococcus multilocularis | cpg binding protein | 0.0011 | 0.0009 | 0.0019 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0014 | 0.0042 | 0.0044 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0759 | 1 | 0.5 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0351 | 0.4546 | 0.4546 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0014 | 0.0042 | 0.0091 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1306 | 0.1388 |
Echinococcus granulosus | phd:f box containing protein | 0.0014 | 0.0042 | 0.0091 |
Echinococcus granulosus | histone deacetylase 6 | 0.0075 | 0.0866 | 0.1879 |
Treponema pallidum | 5'-nucleotidase (ushA) | 0.0063 | 0.0697 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0296 | 0.3819 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0759 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.