Detailed view for TP0104

Basic information

TDR Targets ID: 595739
Treponema pallidum, 5'-nucleotidase (ushA)
Source Database / ID:  KEGG  

pI: 6.241 | Length (AA): 593 | MW (Da): 64871 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase
PF02872   5'-nucleotidase, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016788   hydrolase activity, acting on ester bonds  
GO:0008253   5'-nucleotidase activity  
GO:0000166   nucleotide binding  
GO:0046872   metal ion binding  
GO:0016787   hydrolase activity  
GO:0009166   nucleotide catabolic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 591 3ztv (A) 35 594 50.00 0 1 1.62735 -1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127246)

Species Accession Gene Product
Cryptosporidium hominis Chro.50026   RIKEN cDNA 4933425L06
Cryptosporidium parvum cgd5_3460   nucleotidase (5-nucleotidase/2-cyclic phosphodiesterase) of the calcineurin superfamily
Drosophila melanogaster Dmel_CG30103   CG30103 gene product from transcript CG30103-RA
Drosophila melanogaster Dmel_CG42249   CG42249 gene product from transcript CG42249-RC
Drosophila melanogaster Dmel_CG11883   CG11883 gene product from transcript CG11883-RD
Drosophila melanogaster Dmel_CG30104   Ecto-5'-nucleotidase 2
Drosophila melanogaster Dmel_CG4827   CG4827 gene product from transcript CG4827-RB
Escherichia coli b0480   bifunctional UDP-sugar hydrolase/5'-nucleotidase
Homo sapiens ENSG00000135318   5'-nucleotidase, ecto (CD73)
Mus musculus ENSMUSG00000021718   RIKEN cDNA 4933425L06 gene
Mus musculus ENSMUSG00000032420   5' nucleotidase, ecto
Neospora caninum NCLIV_016240   5-Nucleotidase domain protein (Precursor), related
Schistosoma japonicum Sjp_0301080   ko:K01081 5'-nucleotidase [EC3.1.3.5], putative
Schistosoma mansoni Smp_194100   23-cyclic-nucleotide 2-phosphodiesterase
Schistosoma mansoni Smp_136060   23-cyclic-nucleotide 2-phosphodiesterase
Schmidtea mediterranea mk4.040187.01   Putative 2,3-cyclic-nucleotide 2-phosphodiesterase
Schmidtea mediterranea mk4.007833.04   Putative 2,3-cyclic-nucleotide 2-phosphodiesterase
Schmidtea mediterranea mk4.045113.00  
Toxoplasma gondii TGME49_239620   5'-nucleotidase, C-terminal domain-containing protein
Treponema pallidum TP0104   5'-nucleotidase (ushA)

Essentiality

TP0104 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0480 Escherichia coli non-essential goodall
TGME49_239620 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus 5'-nucleotidase Compounds References
Homo sapiens 5'-nucleotidase, ecto (CD73) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.3172 0.6597 1
0.0985 0.7448 1
0.014 0.577 0.5
0.3663 0.625 1
0.2279 0.4583 0.5
0.0167 0.4483 0.5
0.1849 0.2536 1
0.0143 1 0.5
0.141 0.2549 1
0.1891 0.2596 1
0.0284 0.3379 1
0.3663 0.625 1
0.0167 0.7728 0.5
0.014 1 0.5
0.3663 0.625 1
0.0135 0.3495 1
0.0335 1 0.5
0.3172 0.6597 1
0.3663 0.625 1
0.0159 0.3302 1
0.0287 0.4566 0
0.1874 0.2568 1
0.3172 0.6597 1
0.0168 0.504 0.5
0.208 0.4723 1
0.0335 1 0.5
0.1675 0.2731 1
0.0303 0.6033 0.5
0.0561 0.3358 1
0.0135 0.3147 0.5
0.1827 0.2521 1
0.0139 0.3277 1
0.1244 0.3192 1
0.3172 0.6597 1
0.0138 0.4483 0.5
0.0168 1 0.5
0.3786 0.6715 1
0.208 0.4723 1
0.0065 1 0.5
0.208 0.4723 1
0.208 0.4723 1
0.0167 0.7728 0.5
0.2368 0.6757 0.5
0.208 0.4723 1
0.0152 0.2606 0.5
0.3663 0.625 1
0.0094 0.3431 1
0.0335 1 0.5
0.1391 0.289 1
0.3663 0.625 1
0.1025 1 0.5
0.0556 0.4004 0.5
0.3186 0.5149 0.5
0.016 0.6777 0.5
0.1903 0.2569 1
0.3663 0.625 1
0.0985 0.7448 1
0.3645 0.5669 0.5
0.0541 0.2812 1
0.3958 0.5147 0.5
0.0146 0.2574 0.5
0.3663 0.625 1
0.0143 0.7728 0.5
0.0141 0.7476 0.5
0.1849 0.2536 1
0.0449 0.2595 0.5
0.3663 0.625 1
0.169 0.2731 1
0.208 0.4723 1
0.208 0.4723 1
0.208 0.4723 1
0.0152 0.2606 0.5
0.3353 0.5846 0.5
0.3663 0.625 1
0.3663 0.625 1
0.0167 0.3322 1
0.3513 0.5987 0.5
0.3663 0.625 1
0.208 0.4723 1
0.2797 0.6338 0.5
0.0134 0.3482 1
0.0138 1 0.5
0.0272 0.295 1
0.0449 0.2595 0.5
0.1245 0.2585 1
0.1874 0.2572 1
0.0139 0.3495 1
0.3048 0.4895 0.5
0.2303 0.5191 0.5
0.1849 0.2536 1
0.0287 0.2525 1
0.3663 0.625 1
0.0143 0.4146 0.5
0.0143 0.4685 0.5
0.1708 0.5065 0.5
0.3663 0.625 1
0.1119 0.2529 1
0.3663 0.625 1
0.3385 0.6221 0.5
0.1123 0.2737 1
0.3786 0.6715 1
0.3172 0.6597 1
0.3172 0.6597 1
0.076 0.2503 0.5
0.3335 0.5548 0.5
0.0335 0.7728 0.5
0.3663 0.625 1
0.0335 1 0.5
0.0968 0.265 1
0.1903 0.2569 1
0.0162 0.3764 0.5
0.0311 0.4362 1
0.208 0.4723 1
0.0136 0.323 0.5
0.0294 0.3538 0
0.3663 0.625 1
0.3663 0.625 1
0.0138 0.2859 1
0.208 0.4723 1
0.1834 0.251 1
0.0143 0.6908 0.5
0.0313 0.3593 0.3367
0.0146 0.4544 0.5
0.3663 0.625 1
0.102 0.2525 1
0.014 0.577 0.5
0.0335 0.6033 0.5
0.0065 0.2963 0.9689
0.3663 0.625 1
0.1267 0.2887 1
0.0167 0.336 0.5
0.3663 0.625 1
0.0335 1 0.5
0.0268 0.6145 0.5
0.0272 0.295 1
0.083 0.2993 1
0.0137 0.3495 1
0.3663 0.625 1
0.0335 1 0.5
0.1726 0.6002 1
0.208 0.4723 1
0.0166 0.3764 0.5
0.0461 0.2705 0.5
0.1112 0.3286 1
0.0137 0.3522 1
0.0318 0.6033 0.5
0.208 0.4723 1
0.0335 0.7728 0.5
0.2775 0.8539 0.5
0.3663 0.625 1
0.1131 0.4826 0.5
0.0161 0.3764 0.5
0.0335 0.7728 0.5
0.3663 0.625 1
0.3172 0.6597 1
0.3663 0.625 1
0.029 0.4553 0
0.3663 0.625 1
0.0277 0.2939 0.6539
0.0549 0.6615 1
0.3188 0.7217 0.5
0.2278 0.4519 0.5
0.0335 0.7728 0.5
0.077 0.2572 1
0.0142 1 0.5
0.3663 0.625 1
0.3172 0.6597 1
0.0167 0.4483 0.5
0.076 0.2503 0.5
0.0299 0.4772 0
0.3663 0.625 1
0.0167 0.3764 0.5
0.0167 1 1
0.208 0.4723 1
0.0288 0.4995 0
0.3663 0.625 1
0.0167 0.4679 0.5
0.0985 0.7448 1
0.1123 0.2737 1
0.0136 0.3482 1
0.0167 0.474 0.5
0.0148 0.3764 0.5
0.3663 0.625 1
0.0851 0.5897 1
0.208 0.4723 1
0.0411 0.8075 0.5
0.2141 0.4982 0.5
0.3172 0.6597 1
0.2453 0.5637 0.5
0.0167 0.2521 0.5
0.0335 0.7728 0.5
0.1891 0.257 1
0.1726 0.6002 1
0.3958 0.5147 0.5
0.0137 0.2857 1
0.0449 0.2595 0.5
0.0335 0.7728 0.5
0.0316 0.6033 0.5
0.0167 0.7728 0.5
0.3663 0.625 1
0.1694 0.2638 1
0.0137 0.2513 0.5
0.0134 0.2595 0.3517
0.168 0.2687 1
0.0088 0.3653 0.5
0.0143 0.7728 0.5
0.0136 0.3495 1
0.3663 0.625 1
0.0985 0.7448 1
0.0269 0.6033 0.5
0.3172 0.6597 1
0.2717 0.6418 1
0.1998 0.382 0.5
0.0403 0.2862 1
0.0143 0.4146 0.5
0.0138 0.3495 1
0.0726 1 0.5
0.0137 0.3593 0.5
0.1406 0.3112 1
0.0134 0.3495 1
0.3172 0.6597 1
0.0134 0.3646 1
0.1891 0.257 1
0.2303 0.5191 0.5
0.2303 0.5191 0.5
0.1123 0.2737 1
0.0751 0.4964 1
0.3663 0.625 1
0.0135 0.3147 0.5
0.0547291 1 1
0.3663 0.625 1
0.0143 0.5268 0.5
0.0152 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TP0104 (Treponema pallidum), 5'-nucleotidase (ushA)
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