Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0105 | 0.0704 | 0.0704 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0065 | 0.0237 | 0.0237 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3935 | 0.3788 |
Brugia malayi | Thioredoxin reductase | 0.0126 | 0.0946 | 0.0726 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0065 | 0.0237 | 0.0237 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0384 | 0.3935 | 0.3788 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0105 | 0.0704 | 0.0704 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0065 | 0.0237 | 0.0237 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0065 | 0.0237 | 0.0237 |
Trypanosoma brucei | trypanothione reductase | 0.0126 | 0.0946 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0105 | 0.0704 | 0.0704 |
Schistosoma mansoni | Hyaluronidase | 0.0907 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0076 | 0.036 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0907 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0126 | 0.0946 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0126 | 0.0946 | 0.0946 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0065 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | glutathione reductase | 0.0126 | 0.0946 | 0.0726 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0126 | 0.0946 | 0.0726 |
Toxoplasma gondii | thioredoxin reductase | 0.0126 | 0.0946 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0065 | 0.0237 | 0.0237 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0384 | 0.3935 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0065 | 0.0237 | 0.0237 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0907 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | hyaluronidase | 0.0907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.395 | 0.3803 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0384 | 0.3935 | 0.3935 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3935 | 0.3788 |
Echinococcus multilocularis | serotonin transporter | 0.0384 | 0.3935 | 0.3935 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0065 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | serotonin transporter b | 0.0384 | 0.3935 | 0.3788 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0065 | 0.0237 | 0.0237 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0126 | 0.0946 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0076 | 0.036 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0384 | 0.3935 | 0.3788 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0126 | 0.0946 | 0.3333 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0126 | 0.0946 | 0.0946 |
Echinococcus granulosus | serotonin transporter | 0.0384 | 0.3935 | 0.3935 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3935 | 0.3788 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0126 | 0.0946 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0065 | 0.0237 | 0.0237 |
Plasmodium vivax | glutathione reductase, putative | 0.0126 | 0.0946 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0384 | 0.3935 | 0.3935 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0065 | 0.0237 | 0.0237 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0065 | 0.0237 | 0.0237 |
Plasmodium falciparum | glutathione reductase | 0.0126 | 0.0946 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2116 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0076 | 0.036 | 0.5 |
Leishmania major | trypanothione reductase | 0.0126 | 0.0946 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0065 | 0.0237 | 0.0237 |
Brugia malayi | glutathione reductase | 0.0126 | 0.0946 | 0.0726 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0384 | 0.3935 | 0.3788 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0065 | 0.0237 | 0.0237 |
Onchocerca volvulus | 0.0384 | 0.3935 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0065 | 0.0237 | 0.0237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 3.3 uM | In vitro activity expressed as EC50 for inhibition of collagen induced platelet aggregation. | ChEMBL. | 10197967 |
EC50 (functional) | = 3.3 uM | In vitro activity expressed as EC50 for inhibition of collagen induced platelet aggregation. | ChEMBL. | 10197967 |
IC50 (binding) | = 0.003 uM | In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (binding) | = 0.003 uM | In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (functional) | = 0.055 uM | In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets. | ChEMBL. | 10197967 |
IC50 (functional) | = 0.055 uM | In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets. | ChEMBL. | 10197967 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10197967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.