Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Mus musculus | phosphodiesterase 4A, cAMP specific | Starlite/ChEMBL | References |
Mus musculus | phosphodiesterase 4D, cAMP specific | Starlite/ChEMBL | References |
Mus musculus | phosphodiesterase 4C, cAMP specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 1.4745 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1391 | 0.0518 | 0.0303 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0662 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.4745 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.4745 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.4745 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.4745 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.4745 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.4745 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.4745 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Onchocerca volvulus | 0.1391 | 0.0518 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7379 | 0.477 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1391 | 0.0518 | 0.0518 |
Echinococcus multilocularis | dihydrofolate reductase | 1.4745 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1391 | 0.0518 | 0.0518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Displacement of [3H]-rolipram from mouse brain homogenates | ChEMBL. | 8568798 |
IC50 (binding) | = 0.003 uM | Displacement of [3H]-rolipram from mouse brain homogenates | ChEMBL. | 8568798 |
IC50 (binding) | = 0.11 uM | Inhibition of Phosphodiesterase 4 | ChEMBL. | 8568798 |
IC50 (binding) | = 0.11 uM | Inhibition of Phosphodiesterase 4 | ChEMBL. | 8568798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.