Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1306 | 0.8015 | 0.7481 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.1731 | 0.1731 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0797 | 0.433 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0509 | 0.225 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1164 | 0.1164 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0437 | 0.1731 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.2253 | 0.2253 |
Brugia malayi | Matrixin family protein | 0.0359 | 0.1164 | 0.2401 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.158 | 1 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0437 | 0.1731 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0458 | 0.1882 | 0.0812 |
Brugia malayi | Hemopexin family protein | 0.0509 | 0.225 | 0.4641 |
Mycobacterium ulcerans | hydrolase | 0.0437 | 0.1731 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.158 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0437 | 0.1731 | 0.3569 |
Onchocerca volvulus | 0.0359 | 0.1164 | 0.2689 | |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.051 | 0.2253 | 0.2253 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0491 | 0.2118 | 0.108 |
Brugia malayi | Matrixin family protein | 0.0359 | 0.1164 | 0.2401 |
Brugia malayi | Fibulin-1 precursor | 0.051 | 0.2253 | 0.4646 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.158 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0868 | 0.4849 | 0.4849 |
Loa Loa (eye worm) | hypothetical protein | 0.1516 | 0.9535 | 0.9535 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1306 | 0.8015 | 0.7481 |
Brugia malayi | Matrixin family protein | 0.0868 | 0.4849 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.051 | 0.2253 | 0.4646 |
Loa Loa (eye worm) | hypothetical protein | 0.0644 | 0.3223 | 0.3223 |
Echinococcus multilocularis | fibrillin 1 | 0.051 | 0.2253 | 0.0171 |
Brugia malayi | Matrixin family protein | 0.0359 | 0.1164 | 0.2401 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0458 | 0.1882 | 0.1882 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.051 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.1882 | 0.1882 |
Loa Loa (eye worm) | AStacin protease | 0.0988 | 0.5714 | 0.5714 |
Onchocerca volvulus | 0.0509 | 0.225 | 0.5198 | |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0491 | 0.2118 | 0.2118 |
Echinococcus granulosus | laminin | 0.051 | 0.2253 | 0.0171 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0458 | 0.1882 | 0.388 |
Onchocerca volvulus | Matrilysin homolog | 0.0797 | 0.433 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0458 | 0.1882 | 0.4346 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1164 | 0.1164 |
Echinococcus multilocularis | laminin | 0.051 | 0.2253 | 0.0171 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0359 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.1882 | 0.1882 |
Onchocerca volvulus | Matrilysin homolog | 0.0359 | 0.1164 | 0.2689 |
Brugia malayi | Matrixin family protein | 0.0359 | 0.1164 | 0.2401 |
Loa Loa (eye worm) | matrixin family protein | 0.0797 | 0.433 | 0.433 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0491 | 0.2118 | 0.4368 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.051 | 0.2253 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.257 nM | In Vitro neurotrophic effect was measured in cultured chick DRG sensory neurons. | ChEMBL. | 9857082 |
Ki (binding) | = 194 nM | Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity | ChEMBL. | 9857082 |
Ki (binding) | = 194 nM | Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity | ChEMBL. | 9857082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.