Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cyclin | 0.0116 | 0.0883 | 1 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0117 | 0.0117 |
Schistosoma mansoni | cyclin B3 | 0.022 | 0.3548 | 0.3548 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.0883 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.0883 | 0.2488 |
Trypanosoma cruzi | cyclin, putative | 0.0116 | 0.0883 | 1 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0086 | 0.0117 | 0.1324 |
Echinococcus multilocularis | cyclin b3 | 0.0086 | 0.0117 | 0.0117 |
Trypanosoma cruzi | cyclin, putative | 0.0116 | 0.0883 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0116 | 0.0883 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0086 | 0.0117 | 0.1324 |
Plasmodium vivax | hypothetical protein, conserved | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.0883 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.0883 | 1 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Echinococcus multilocularis | cyclin B | 0.0116 | 0.0883 | 0.0883 |
Giardia lamblia | Cyclin A | 0.0086 | 0.0117 | 0.1324 |
Onchocerca volvulus | 0.0473 | 1 | 1 | |
Echinococcus granulosus | cyclin B | 0.0116 | 0.0883 | 0.0883 |
Toxoplasma gondii | flagellar/basal body protein | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.0883 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.022 | 0.3548 | 0.3548 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.0883 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0086 | 0.0117 | 0.1324 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0117 | 0.0117 |
Trichomonas vaginalis | cyclins, putative | 0.0086 | 0.0117 | 0.1324 |
Giardia lamblia | Hypothetical protein | 0.0086 | 0.0117 | 0.1324 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.022 | 0.3548 | 0.3548 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0473 | 1 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0086 | 0.0117 | 0.0117 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Trypanosoma cruzi | cyclin 6, putative | 0.0116 | 0.0883 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.0117 | 0.1324 |
Trichomonas vaginalis | cyclin D, putative | 0.0086 | 0.0117 | 0.1324 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.0883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0883 | 0.1113 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0473 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0116 | 0.0883 | 1 |
Onchocerca volvulus | 0.0116 | 0.0883 | 0.0883 | |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.022 | 0.3548 | 0.4475 |
Echinococcus granulosus | cyclin b3 | 0.0086 | 0.0117 | 0.0117 |
Trichomonas vaginalis | cyclin A, putative | 0.0116 | 0.0883 | 1 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Onchocerca volvulus | 0.0473 | 1 | 1 | |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0116 | 0.0883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0883 | 0.1113 |
Echinococcus multilocularis | cyclin B3 1 | 0.0086 | 0.0117 | 0.0117 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0081 | 0 | 0.5 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0117 | 0.0117 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.0883 | 0.2488 |
Schistosoma mansoni | cyclins | 0.0086 | 0.0117 | 0.0117 |
Schistosoma mansoni | cyclin B | 0.0116 | 0.0883 | 0.0883 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0116 | 0.0883 | 1 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0117 | 0.0117 |
Onchocerca volvulus | 0.0473 | 1 | 1 | |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.0883 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0116 | 0.0883 | 1 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0117 | 0.0117 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.022 | 0.3548 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.0883 | 1 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.7928 | 1 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0473 | 1 | 1 |
Onchocerca volvulus | 0.0473 | 1 | 1 | |
Plasmodium falciparum | cyclin | 0.0086 | 0.0117 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Inhibition of cyclic dependent kinase 2 (CDK2)/cyclin E | ChEMBL. | 11170642 |
IC50 (binding) | = 50 nM | Inhibition of cyclic dependent kinase 2 (CDK2)/cyclin E | ChEMBL. | 11170642 |
IC50 (binding) | = 226 nM | Inhibition of human cyclic dependent kinase 1 (CDK1)/cyclin B | ChEMBL. | 11170642 |
IC50 (binding) | = 226 nM | Inhibition of human cyclic dependent kinase 1 (CDK1)/cyclin B | ChEMBL. | 11170642 |
IC50 (binding) | = 2000 nM | Inhibition of cyclic dependent kinase 4 (CDK4)/cyclin D1 | ChEMBL. | 11170642 |
IC50 (binding) | = 2000 nM | Inhibition of cyclic dependent kinase 4 (CDK4)/cyclin D1 | ChEMBL. | 11170642 |
IC50 (functional) | = 0.6 uM | Inhibition of MCF-7 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 0.6 uM | Inhibition of MCF-7 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of MDA-MB-231 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of A549 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of DMS-114 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of MDA-MB-231 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of A549 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1 uM | Inhibition of DMS-114 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.2 uM | Inhibition of HT-29 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.2 uM | Inhibition of HT-29 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.4 uM | Inhibition of PC-3 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.4 uM | Inhibition of PC-3 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.6 uM | Inhibition of DU-145 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.6 uM | Inhibition of DU-145 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 2.1 uM | Inhibition of HCT-15 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 2.1 uM | Inhibition of HCT-15 human colon tumor cell proliferation | ChEMBL. | 11170642 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11170642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.