Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2995 | 0.4765 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Leishmania major | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.024 | 0.6285 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.0246 | 0.6454 | 0.6454 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.092 | 0.1464 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0134 | 0.3277 | 0.5214 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.024 | 0.6285 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Echinococcus granulosus | thymidine kinase | 0.024 | 0.6285 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2995 | 0.4765 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0134 | 0.3277 | 0.5214 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2995 | 0.4765 |
Echinococcus multilocularis | transfer RNA-Ile | 0.024 | 0.6285 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0246 | 0.6454 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0246 | 0.6454 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 6 % | Percent inhibition of SRS-A induced contraction minus percent inhibition of 25 mM KCl induced contractions at a conc of 5(microM); Percent enhancement of tissue contraction compared to control | ChEMBL. | 7143363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.