Detailed information for compound 261852

Basic information

Technical information
  • TDR Targets ID: 261852
  • Name: 7-methoxy-2-(4-methylphenyl)-6-(1,3-oxazol-5- yl)-1H-quinolin-4-one
  • MW: 332.353 | Formula: C20H16N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nc(cc(c2cc1c1cnco1)O)c1ccc(cc1)C
  • InChi: 1S/C20H16N2O3/c1-12-3-5-13(6-4-12)16-8-18(23)14-7-15(20-10-21-11-25-20)19(24-2)9-17(14)22-16/h3-11H,1-2H3,(H,22,23)
  • InChiKey: NDACTGITQVDOGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methoxy-6-oxazol-5-yl-2-(p-tolyl)-1H-quinolin-4-one
  • 7-methoxy-6-(5-oxazolyl)-2-(p-tolyl)-1H-quinolin-4-one
  • 7-methoxy-6-oxazol-5-yl-2-(p-tolyl)-4-quinolone
  • 7-methoxy-2-(4-methylphenyl)-6-oxazol-5-yl-1H-quinolin-4-one
  • 7-methoxy-2-(4-methylphenyl)-6-(5-oxazolyl)-1H-quinolin-4-one
  • 7-methoxy-2-(4-methylphenyl)-6-oxazol-5-yl-4-quinolone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 1 Starlite/ChEMBL References
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.6359 0.6209
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.683 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0396 0.1123
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.019 0.683 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.019 0.683 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.2606 0.3435
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0396 0.1123
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.3525 0.3457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.283 0.2535
Plasmodium falciparum thioredoxin reductase 0.0048 0.0746 0.1176
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0746 0.1176
Echinococcus granulosus geminin 0.0186 0.6666 0.9744
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.3525 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.2076 0.1749
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.019 0.683 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.1778 0.2149
Toxoplasma gondii thioredoxin reductase 0.0048 0.0746 0.1092
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0396 0.1123
Toxoplasma gondii IMP dehydrogenas 0.019 0.683 1
Loa Loa (eye worm) hypothetical protein 0.0263 1 1
Brugia malayi 6-phosphofructokinase 0.0113 0.3525 0.3258
Onchocerca volvulus Huntingtin homolog 0.0263 1 1
Trypanosoma cruzi GMP reductase 0.019 0.683 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0746 0.1176
Onchocerca volvulus 0.0091 0.2606 0.0669
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.6359 0.9267
Loa Loa (eye worm) phosphofructokinase 0.0113 0.3525 0.3258
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.3525 0.4863
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0178 0.6347 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.2606 0.2301
Schistosoma mansoni hypothetical protein 0.0186 0.6666 0.9744
Loa Loa (eye worm) hypothetical protein 0.0263 1 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.2606 0.2301
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.019 0.683 1
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.3525 0.4863
Schistosoma mansoni alpha-glucosidase 0.0154 0.5291 0.7609
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.3525 0.4567
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1778 0.2149
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.3525 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.01 0.2966 0.3649
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.1778 0.2149
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0746 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.283 0.3784
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0746 0.0365
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.6359 0.6209
Brugia malayi glutathione reductase 0.0048 0.0746 0.0365
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.1682 0.1998
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0178 0.6347 0.9044
Plasmodium falciparum glutathione reductase 0.0048 0.0746 0.1176
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.283 0.3784
Mycobacterium tuberculosis Probable reductase 0.0109 0.3373 0.4318
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0396 0.1123
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.3373 0.4318
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0746 0.0545
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.3525 0.4863
Brugia malayi 6-phosphofructokinase 0.0113 0.3525 0.3258
Brugia malayi phosphofructokinase 0.0113 0.3525 0.3258
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.683 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0396 0.1123
Echinococcus granulosus transcription factor Dp 1 0.004 0.0424 0.0044
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0396 0.1123
Onchocerca volvulus Huntingtin homolog 0.0263 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.3525 0.4863
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0 0.5
Trypanosoma brucei GMP reductase 0.019 0.683 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.019 0.683 1
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.3525 0.4863
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.3373 0.4318
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3896 0.3129
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.3525 0.2261
Trypanosoma cruzi GMP reductase 0.019 0.683 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.3525 0.3258
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.3373 0.4318
Loa Loa (eye worm) IMP dehydrogenase 1 0.019 0.683 0.6699
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.3525 1
Brugia malayi GMP reductase 0.0079 0.2076 0.1749
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.1682 0.1339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.283 0.3784
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3896 0.5177
Onchocerca volvulus 0.0103 0.3128 0.1327
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1682 0.1998
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0396 0.1123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.283 0.3784
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0178 0.6347 1
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.3525 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.3373 0.4318
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.3525 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.683 1
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.1778 0.2149
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.1778 0.2604
Leishmania major guanosine monophosphate reductase 0.019 0.683 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.3525 0.3258
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.019 0.683 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0424 0.0044
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.3525 1
Leishmania major trypanothione reductase 0.0048 0.0746 0.0545
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.6359 0.9267
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.1682 0.1998
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.3525 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.3373 0.1907
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0396 0.1123
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0396 0.1123
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.3373 0.4318
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.1682 0.1998
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0396 0.1123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.283 0.2535
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.009 0.2559 0.1545
Schistosoma mansoni alpha-glucosidase 0.0154 0.5291 0.7609
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.01 0.2966 0.0954
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.3525 0.4863
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1682 0.1998
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.019 0.683 1
Loa Loa (eye worm) GMP reductase 0.0079 0.2076 0.1749
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.2606 0.3435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.283 0.3784
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.3525 0.4863
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.6359 0.9267
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.1682 0.4771
Loa Loa (eye worm) glutathione reductase 0.0048 0.0746 0.0365
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.1778 0.1697
Schistosoma mansoni hypothetical protein 0.0186 0.6666 0.9744
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.1778 0.2149
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.019 0.683 0.6699
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.019 0.683 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0396 0.1123
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3896 0.5177
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0079 0.2076 0.1749
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.283 0.3784
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.1682 0.1339
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1682 0.1998
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3896 0.5177
Trypanosoma brucei trypanothione reductase 0.0048 0.0746 0.0545
Echinococcus multilocularis geminin 0.0186 0.6666 0.9744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.283 0.3784
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.3525 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.2606 0.3435
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0746 0.0545
Brugia malayi Thioredoxin reductase 0.0048 0.0746 0.0365
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.1682 0.1998
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0396 0.0579
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.019 0.683 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 0.005 uM Inhibition of human inosine monophosphate dehydrogenase IMPDH II ChEMBL. 12565968
IC50 (binding) < 0.005 uM Inhibition of human inosine monophosphate dehydrogenase IMPDH II ChEMBL. 12565968
IC50 (binding) = 0.046 uM Inhibitory activity of the compound against inosine monophosphate dehydrogenase IMPDH type I ChEMBL. 12565968
IC50 (binding) = 0.046 uM Inhibitory activity of the compound against inosine monophosphate dehydrogenase IMPDH type I ChEMBL. 12565968
IC50 (functional) = 0.56 uM Inhibitory activity of the compound against CEM cell proliferation ChEMBL. 12565968
IC50 (functional) = 0.56 uM Inhibitory activity of the compound against CEM cell proliferation ChEMBL. 12565968
Ratio (binding) > 9 Ratio of IC50(Type I) to IC50(Type II) ChEMBL. 12565968
Ratio (binding) > 9 Ratio of IC50(Type I) to IC50(Type II) ChEMBL. 12565968

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12565968

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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