Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0247 | 0.1061 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0338 | 0.0338 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0031 | 0.027 | 0.1158 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0031 | 0.027 | 0.1046 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2328 | 0.9035 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0338 | 0.131 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.0668 | 0.1617 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.017 | 0.2328 | 0.2328 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0247 | 0.0247 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0031 | 0.027 | 0.1158 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Onchocerca volvulus | 0.0187 | 0.2577 | 1 | |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0554 | 0.2152 |
Trypanosoma brucei | phosphoglycerate kinase | 0.017 | 0.2328 | 1 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0031 | 0.027 | 0.027 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.1226 | 0.1226 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0247 | 0.0959 |
Schistosoma mansoni | phosphoglycerate kinase | 0.017 | 0.2328 | 0.2328 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0031 | 0.027 | 0.1158 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0062 | 0.0739 | 0.3173 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 0.5638 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0247 | 0.0598 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.069 | 1 | 1 |
Giardia lamblia | Phosphoglycerate kinase | 0.017 | 0.2328 | 0.5638 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0143 | 0.1924 | 0.328 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0705 | 0.2736 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0031 | 0.027 | 0.027 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.017 | 0.2328 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0338 | 0.0338 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0187 | 0.2577 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0062 | 0.0739 | 0.2867 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.017 | 0.2328 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0187 | 0.2577 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.0668 | 0.2868 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0247 | 0.0247 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.017 | 0.2328 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.0062 | 0.0739 | 0.3173 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0936 | 0.0936 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.017 | 0.2328 | 1 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0247 | 0.0247 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Loa Loa (eye worm) | SMO-1 protein | 0.0031 | 0.027 | 0.1046 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.017 | 0.2328 | 0.6193 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0338 | 0.0338 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0247 | 0.0247 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.1226 | 0.4757 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.0668 | 0.2868 |
Plasmodium falciparum | phosphoglycerate kinase | 0.017 | 0.2328 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.017 | 0.2328 | 0.9035 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0247 | 0.1061 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0247 | 0.1061 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.027 | 0.0653 |
Trypanosoma brucei | phosphoglycerate kinase | 0.017 | 0.2328 | 1 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.017 | 0.2328 | 0.2328 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0247 | 0.0959 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0338 | 0.131 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0031 | 0.027 | 0.1158 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.0668 | 0.2868 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0338 | 0.0338 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.0668 | 0.1617 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 0.5638 |
Leishmania major | small ubiquitin protein, putative | 0.0031 | 0.027 | 0.1158 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Giardia lamblia | Sentrin | 0.0031 | 0.027 | 0.0653 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0187 | 0.2577 | 0.624 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.017 | 0.2328 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.017 | 0.2328 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0416 | 0.0416 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0247 | 0.0959 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0292 | 0.413 | 1 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.017 | 0.2328 | 0.5638 |
Entamoeba histolytica | ubiquitin like protein | 0.0031 | 0.027 | 0.0653 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0031 | 0.027 | 0.027 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0247 | 0.0247 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.017 | 0.2328 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.017 | 0.2328 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0187 | 0.2577 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0292 | 0.413 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0247 | 0.1061 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0187 | 0.2577 | 0.624 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0247 | 0.0959 |
Schistosoma mansoni | phosphoglycerate kinase | 0.017 | 0.2328 | 0.2328 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.1226 | 0.1226 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.069 | 1 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0062 | 0.0739 | 0.3173 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0292 | 0.413 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0668 | 0.2868 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.4 ug ml-1 | Cytotoxicity in human embryonic lung flbroblast Wl-38 cells using WST-1 viability assay | ChEMBL. | 10098663 |
IC50 (binding) | = 15.1 ug ml-1 | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 15.1 ug ml-1 | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 40.5 ug ml-1 | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 40.5 ug ml-1 | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (functional) | = 3.4 uM | Cytotoxicity in human embryonic lung flbroblast Wl-38 cells using WST-1 viability assay | ChEMBL. | 10098663 |
IC50 (binding) | = 36.7 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 36.7 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 98.4 uM | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 98.4 uM | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.