TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.458 | Formula: C17H23N5O9S
H donors: 7 H acceptors: 9 LogP: -2.82 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CNC(=O)c1ccc(cc1)S(=O)(=O)N)NCC(=O)NCC(=O)NC(C(=O)O)C(O)C
InChi: 1S/C17H23N5O9S/c1-9(23)15(17(28)29)22-14(26)8-20-12(24)6-19-13(25)7-21-16(27)10-2-4-11(5-3-10)32(18,30)31/h2-5,9,15,23H,6-8H2,1H3,(H,19,25)(H,20,24)(H,21,27)(H,22,26)(H,28,29)(H2,18,30,31)
InChiKey: GEIKPXQNWOWHFG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	neuropeptide F receptor	0.0302	0.0208	0.0199
Loa Loa (eye worm)	carbonic anhydrase 3	0.0147	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Schistosoma mansoni	myosin xvIII	0.0302	0.0208	0.0187
Echinococcus granulosus	dro:myosuppressin receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	casein kinase I delta	0.0167	0.0046	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0302	0.0208	0.0187
Echinococcus granulosus	glycyl tRNA synthetase	0.0209	0.0096	0.0075
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Brugia malayi	G protein-coupled receptor	0.0302	0.0208	0.0187
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1906	0.2135	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	ORL1-like opioid receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	neuropeptide receptor A26	0.0302	0.0208	0.0187
Schistosoma mansoni	hypothetical protein	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0302	0.0208	0.0187
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0302	0.0208	0.0187
Echinococcus granulosus	tm gpcr rhodopsin	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Echinococcus granulosus	g protein coupled receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	casein kinase I alpha	0.0167	0.0046	0.0024
Echinococcus granulosus	neuropeptide receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	hypothetical protein	0.0302	0.0208	0.0187
Loa Loa (eye worm)	melatonin receptor type 1A	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0197	0.0081	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0167	0.0046	0.0037
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Echinococcus multilocularis	fmrfamide receptor	0.0302	0.0208	0.0187
Trypanosoma cruzi	casein kinase, putative	0.0167	0.0046	1
Onchocerca volvulus		0.0302	0.0208	1
Echinococcus multilocularis	g protein coupled receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide Y receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	GnHR receptor homolog	0.0302	0.0208	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0302	0.0208	0.0187
Schistosoma mansoni	histamine h1 receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptides capa receptor	0.0302	0.0208	0.0187
Brugia malayi	AKH receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	opsin-like receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	g-protein coupled receptor	0.0302	0.0208	0.0187
Trypanosoma cruzi	casein kinase, putative	0.0167	0.0046	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0302	0.0208	1
Echinococcus granulosus	casein kinase I delta	0.0167	0.0046	0.0024
Brugia malayi	sulfakinin receptor protein	0.0302	0.0208	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Plasmodium vivax	casein kinase 1, putative	0.0167	0.0046	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0302	0.0208	0.0187
Echinococcus granulosus	orexin receptor type 2	0.0302	0.0208	0.0187
Schistosoma mansoni	biogenic amine receptor	0.0302	0.0208	0.0187
Trypanosoma cruzi	casein kinase, putative	0.0167	0.0046	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	neuropeptides capa receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	orexin receptor type 2	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.8446	1	1
Echinococcus granulosus	serotonin receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	casein kinase 1, delta	0.0167	0.0046	0.0024
Schistosoma mansoni	protein kinase	0.8446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.8446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	adenoreceptor	0.0302	0.0208	0.0187
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1906	0.2135	0.2119
Echinococcus granulosus	biogenic amine 5HT receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	dual specificity mitogen activated protein	0.8446	1	1
Trichomonas vaginalis	CK1 family protein kinase	0.0167	0.0046	0.5
Brugia malayi	methionyl-tRNA synthetase	0.0269	0.0168	0.0147
Brugia malayi	Melatonin receptor type 1A	0.0302	0.0208	0.0187
Echinococcus granulosus	fmrfamide receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1906	0.2135	0.2119
Echinococcus granulosus	casein kinase I gamma	0.0175	0.0054	0.0033
Trypanosoma cruzi	casein kinase, putative	0.0167	0.0046	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	opsin-like receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	casein kinase I	0.0167	0.0046	0.0024
Brugia malayi	RE15519p	0.0302	0.0208	0.0187
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0302	0.0208	0.0187
Schistosoma mansoni	hypothetical protein	0.0302	0.0208	0.0187
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0302	0.0208	0.0187
Schistosoma mansoni	amine GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0269	0.0168	0.0159
Brugia malayi	Serine/threonine-protein kinase F42G10.2	0.0197	0.0081	0.006
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	casein kinase I gamma	0.0175	0.0054	0.0033
Brugia malayi	larval opioid receptor	0.0302	0.0208	0.0187
Giardia lamblia	Kinase, CK1 Casein kinase	0.0167	0.0046	0.5
Echinococcus multilocularis	casein kinase i	0.0167	0.0046	0.0024
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0302	0.0208	0.0187
Echinococcus multilocularis	sex peptide receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0302	0.0208	0.0187
Trichomonas vaginalis	CK1 family protein kinase	0.0167	0.0046	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0269	0.0168	0.0147
Echinococcus granulosus	allatostatin A receptor	0.0302	0.0208	0.0187
Brugia malayi	Serotonin receptor	0.0302	0.0208	0.0187
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Echinococcus multilocularis	somatostatin receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	glycyl tRNA synthetase	0.0209	0.0096	0.0075
Echinococcus granulosus	neuropeptides capa receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	G-protein coupled receptor	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0302	0.0208	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Trypanosoma brucei	casein kinase I, isoform 2	0.0167	0.0046	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0302	0.0208	0.0187
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1906	0.2135	0.2129
Echinococcus multilocularis	casein kinase I alpha	0.0167	0.0046	0.0024
Schistosoma mansoni	kinase	0.0197	0.0081	0.006
Echinococcus multilocularis	neuropeptide s receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	g protein coupled receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	tm gpcr rhodopsin	0.0302	0.0208	0.0187
Echinococcus granulosus	somatostatin receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	g-protein coupled receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0209	0.0096	0.0087
Onchocerca volvulus		0.0302	0.0208	1
Schistosoma mansoni	amine GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0302	0.0208	0.0187
Toxoplasma gondii	casein kinase I	0.0167	0.0046	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0302	0.0208	0.0199
Schistosoma mansoni	biogenic amine receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0147	0.0021	0.0013
Schistosoma mansoni	neuropeptide f receptor 76f	0.0302	0.0208	0.0187
Echinococcus multilocularis	serotonin receptor	0.0302	0.0208	0.0187
Plasmodium falciparum	casein kinase 1	0.0167	0.0046	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0302	0.0208	0.0187
Schistosoma mansoni	neuropeptide receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	protein kinase	0.0167	0.0046	0.0024
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0302	0.0208	0.0187
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0302	0.0208	0.0199
Schistosoma mansoni	opsin-like receptor	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Brugia malayi	neuropeptide F receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	g protein coupled receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	neuropeptide receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Leishmania major	casein kinase, putative	0.0167	0.0046	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0302	0.0208	0.0187
Brugia malayi	G-protein coupled receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0302	0.0208	0.0199
Onchocerca volvulus		0.0302	0.0208	1
Onchocerca volvulus		0.0302	0.0208	1
Schistosoma mansoni	methionine-tRNA synthetase	0.0269	0.0168	0.0147
Onchocerca volvulus		0.0302	0.0208	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0302	0.0208	0.0187
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0021	0.4659
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0302	0.0208	0.0187
Echinococcus multilocularis	dro:myosuppressin receptor	0.0302	0.0208	0.0187
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide receptor	0.0302	0.0208	0.0187
Brugia malayi	Dopamine receptor protein 2	0.0302	0.0208	0.0187
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0302	0.0208	0.0187
Echinococcus granulosus	G protein coupled receptor 139	0.0302	0.0208	0.0187
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	follicle stimulating hormone receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	G protein coupled receptor 139	0.0302	0.0208	0.0187
Schistosoma mansoni	growth hormone secretagogue receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.1372	0.1493	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Echinococcus multilocularis	allatostatin A receptor	0.0302	0.0208	0.0187
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0302	0.0208	1
Loa Loa (eye worm)	TYRA-2 protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	g protein coupled receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	neuropeptide F-like receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	serine/threonine protein kinase	0.0175	0.0054	0.0033
Echinococcus multilocularis	casein kinase I delta	0.0167	0.0046	0.0024
Loa Loa (eye worm)	multisynthetase complex auxiliary component p43	0.0226	0.0116	0.0108
Onchocerca volvulus		0.0302	0.0208	1
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.1363	0.1483	0.1475
Loa Loa (eye worm)	neuropeptide F receptor	0.0302	0.0208	0.0199
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0167	0.0046	0.0037
Schistosoma mansoni	neuropeptide receptor	0.0302	0.0208	0.0187
Brugia malayi	putative neuropeptide receptor NPR1	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Schistosoma mansoni	amine GPCR	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Onchocerca volvulus		0.0302	0.0208	1
Trypanosoma cruzi	casein kinase, putative	0.0167	0.0046	1
Onchocerca volvulus		0.0167	0.0046	0.2193
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.1363	0.1483	0.1465
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	Protein kinase domain containing protein	0.1363	0.1483	0.1465
Schistosoma mansoni	neuropeptide receptor	0.0302	0.0208	0.0187
Brugia malayi	neuropeptide F receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Echinococcus multilocularis	casein kinase I delta	0.0167	0.0046	0.0024
Echinococcus multilocularis	casein kinase I alpha	0.0167	0.0046	0.0024
Echinococcus granulosus	neuropeptide FF receptor 2	0.0302	0.0208	0.0187
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Brugia malayi	Protein kinase domain containing protein	0.0175	0.0054	0.0033
Schistosoma mansoni	amine GPCR	0.0302	0.0208	0.0187
Schistosoma mansoni	serine/threonine protein kinase	0.0167	0.0046	0.0024
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0302	0.0208	0.0187
Echinococcus granulosus	dual specificity mitogen activated protein	0.0197	0.0081	0.006
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0302	0.0208	0.0199
Brugia malayi	Serotonin receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	hypothetical protein	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide Y receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	neuropeptide receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	biogenic amine 5HT receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0302	0.0208	0.0187
Onchocerca volvulus	Kinase homolog	0.0197	0.0081	0.3879
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0167	0.0046	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	g protein coupled receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0302	0.0208	0.0187
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0197	0.0081	0.006
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Treponema pallidum	methionyl-tRNA synthetase	0.0269	0.0168	0.5
Chlamydia trachomatis	methionine--tRNA ligase	0.0269	0.0168	0.5
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	G protein-coupled receptor F59B2.13	0.0302	0.0208	0.0187
Echinococcus granulosus	casein kinase I alpha	0.0167	0.0046	0.0024
Echinococcus granulosus	neuropeptide Y receptor	0.0302	0.0208	0.0187
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0302	0.0208	0.0187
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0302	0.0208	0.0187
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0269	0.0168	1
Brugia malayi	hypothetical protein	0.0302	0.0208	0.0187
Brugia malayi	Dopamine receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	biogenic amine receptor	0.0302	0.0208	0.0187
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.0021	0.4659
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0269	0.0168	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	casein kinase I alpha	0.0167	0.0046	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1906	0.2135	0.2119
Echinococcus granulosus	7tm_1 domain containing protein	0.0302	0.0208	0.0187
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0302	0.0208	0.0187
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	glycyl-tRNA synthetase	0.0209	0.0096	0.0075
Schistosoma mansoni	hypothetical protein	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	dual specificity mitogen activated protein	0.8446	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	casein kinase i	0.0167	0.0046	0.0024
Schistosoma mansoni	neuropeptide F-like receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0302	0.0208	0.0199
Echinococcus multilocularis	fmrfamide receptor	0.0302	0.0208	0.0187
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0209	0.0096	0.0075
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0209	0.0096	0.0087
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	amine GPCR	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Echinococcus granulosus	casein kinase I alpha	0.0167	0.0046	0.0024
Brugia malayi	Dopamine receptor protein 1	0.0302	0.0208	0.0187
Echinococcus multilocularis	serotonin receptor	0.0302	0.0208	0.0187
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0302	0.0208	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Echinococcus granulosus	sex peptide receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0302	0.0208	0.0187
Brugia malayi	G-protein coupled receptor	0.0302	0.0208	0.0187
Echinococcus granulosus	neuropeptide Y receptor	0.0302	0.0208	0.0187
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0302	0.0208	0.0199
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0302	0.0208	0.0187
Schistosoma mansoni	glycyl-tRNA synthetase	0.0209	0.0096	0.0075
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0302	0.0208	0.0187
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0302	0.0208	0.0187
Echinococcus multilocularis	neuropeptide receptor A26	0.0302	0.0208	0.0187
Onchocerca volvulus		0.0302	0.0208	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0175	0.0054	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Trichomonas vaginalis	CK1 family protein kinase	0.0167	0.0046	0.5
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0167	0.0046	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0208	0.0199
Brugia malayi	putative neuropeptide receptor	0.0302	0.0208	0.0187

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 330 nM	Dissociation constant against human carbonic anhydrase II at 37 degree centigrade	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 355167

Bibliographic References

No literature references available for this target.

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Detailed information for compound 263613