Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adam | 0.0264 | 0.0145 | 0.0131 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0284 | 0.0168 | 0.0242 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.029 | 0.0176 | 0.0264 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.5201 | 0.5982 | 0.9548 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0203 | 0.0073 | 0.0164 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.283 | 0.3178 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.577 | 0.6654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.0458 | 0.0677 |
Onchocerca volvulus | Matrilysin homolog | 0.5438 | 0.6263 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Brugia malayi | angiogenesis inhibito | 0.0152 | 0.0012 | 0.0019 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.2291 | 0.2542 | 0.7108 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.024 | 0.0117 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0101 | 0.0141 |
Echinococcus granulosus | adam | 0.0264 | 0.0145 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.2636 | 0.3955 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.283 | 0.3178 | 0.4776 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0227 | 0.0102 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0176 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.2636 | 0.3955 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0307 | 0.0196 | 0.0182 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0179 | 0.0044 | 0.0085 |
Brugia malayi | Disintegrin family protein | 0.0153 | 0.0014 | 0.0021 |
Onchocerca volvulus | 0.3161 | 0.357 | 0.5664 | |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.132 | 0.1394 | 0.388 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0282 | 0.0166 | 0.0427 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.0065 | 0.1027 |
Brugia malayi | hypothetical protein | 0.0264 | 0.0145 | 0.0218 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0229 | 0.0104 | 0.009 |
Brugia malayi | Hemopexin family protein | 0.3161 | 0.357 | 0.5365 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0264 | 0.0145 | 0.0367 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2609 | 0.2917 | 0.8163 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0229 | 0.0104 | 0.009 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0179 | 0.0044 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.283 | 0.3178 | 0.477 |
Onchocerca volvulus | 0.2371 | 0.2636 | 0.416 | |
Brugia malayi | Matrixin family protein | 0.577 | 0.6654 | 1 |
Brugia malayi | Matrixin family protein | 0.2371 | 0.2636 | 0.3962 |
Brugia malayi | Matrixin family protein | 0.2371 | 0.2636 | 0.3962 |
Loa Loa (eye worm) | hypothetical protein | 0.2609 | 0.2917 | 0.4377 |
Loa Loa (eye worm) | reprolysin | 0.0227 | 0.0102 | 0.0141 |
Brugia malayi | ADAMTS-like protease | 0.0152 | 0.0012 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.3161 | 0.357 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0284 | 0.0168 | 0.0253 |
Echinococcus granulosus | adam 17 protease | 0.0289 | 0.0174 | 0.016 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.2371 | 0.2636 | 0.3955 |
Onchocerca volvulus | Matrilysin homolog | 0.2371 | 0.2636 | 0.416 |
Brugia malayi | Matrixin family protein | 0.2371 | 0.2636 | 0.3962 |
Echinococcus multilocularis | adam 17 protease | 0.0203 | 0.0073 | 0.0058 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0227 | 0.0102 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0034 | 0.0039 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.283 | 0.3178 | 0.5 |
Brugia malayi | hypothetical protein | 0.0227 | 0.0101 | 0.0152 |
Brugia malayi | Matrixin family protein | 0.2371 | 0.2636 | 0.3962 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0227 | 0.0102 | 0.0246 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.0065 | 0.1027 |
Loa Loa (eye worm) | matrixin family protein | 0.5201 | 0.5982 | 0.8988 |
Brugia malayi | sulfakinin receptor protein | 0.0227 | 0.0101 | 0.0152 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.8599 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.0168 | 1 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0227 | 0.0102 | 0.0246 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0179 | 0.0044 | 0.003 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0282 | 0.0166 | 0.0427 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0307 | 0.0196 | 0.0182 |
Mycobacterium ulcerans | hydrolase | 0.283 | 0.3178 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 32 mg kg-1 | This is the dose at which optimal activity was observed against P-388 leukemia cells | ChEMBL. | 7381856 |
Dose (functional) | = 32 mg kg-1 | This is the dose at which optimal activity was observed against P-388 leukemia cells | ChEMBL. | 7381856 |
Dose range (functional) | = 32 mg kg-1 | Antileukemic activity against P-388 leukemia cells was measured at given dose range | ChEMBL. | 7381856 |
Dose range (functional) | = 32 mg kg-1 | Antileukemic activity against P-388 leukemia cells was measured at given dose range | ChEMBL. | 7381856 |
ED50 (functional) | > 10000000000 ug ml-1 | In vitro cytotoxicity of compound was tested against 9KB cells. | ChEMBL. | 7381856 |
T/C (functional) | = 175 % | Optimal activity expressed as percentage treated to that of control was measured in vivo against P-388 leukemia cells | ChEMBL. | 7381856 |
T/C (functional) | = 175 % | Optimal activity expressed as percentage treated to that of control was measured in vivo against P-388 leukemia cells | ChEMBL. | 7381856 |
Therapeutic index (ADMET) | = 2 | Therapeutic index was measured on P-388 leukemia cells against P-388 leukemia cells | ChEMBL. | 7381856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.