TDR Targets

Basic information

Technical information

TDR Targets ID: 264474
Name: pyridin-4-ylmethyl 8-chloro-5-oxidopyrazolo[5 ,1-c][1,2,4]benzotriazin-5-ium-3-carboxylate
MW: 355.735 | Formula: C16H10ClN5O3
H donors: 0 H acceptors: 5 LogP: 1.23 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)n1ncc(c1n[n+]2[O-])C(=O)OCc1ccncc1
InChi: 1S/C16H10ClN5O3/c17-11-1-2-13-14(7-11)21-15(20-22(13)24)12(8-19-21)16(23)25-9-10-3-5-18-6-4-10/h1-8H,9H2
InChiKey: BMIKDIWICOAHJN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-pyridylmethyl 8-chloro-5-oxido-pyrazolo[5,1-c][1,2,4]benzotriazin-5-ium-3-carboxylate
8-chloro-5-oxido-3-pyrazolo[5,1-c][1,2,4]benzotriazin-5-iumcarboxylic acid 4-pyridylmethyl ester
pyridin-4-ylmethyl 8-chloro-5-oxidanidyl-pyrazolo[5,1-c][1,2,4]benzotriazin-5-ium-3-carboxylate
8-chloro-5-oxido-pyrazolo[5,1-c][1,2,4]benzotriazin-5-ium-3-carboxylic acid 4-pyridylmethyl ester
pyridin-4-ylmethyl 8-chloro-5-oxido-pyrazolo[5,1-c][1,2,4]benzotriazin-5-ium-3-carboxylate

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.1039	0.2874	0.2728
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0142	0.0341
Brugia malayi	hypothetical protein	0.0081	0.02	0.0755
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.0534	0.7522
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0015	0.0015
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0015	0.0208
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0015	0.0056
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Brugia malayi	Pre-SET motif family protein	0.0029	0.0053	0.0201
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0035	0.007	0.0264
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0015	0.0056
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0015	0.0056
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0142	0.0536
Brugia malayi	reverse transcriptase	0.0081	0.02	0.0755
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0015	0.0208
Brugia malayi	RNase H family protein	0.0957	0.2647	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0053
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0015	0.0056
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.007	0.0264
Treponema pallidum	ribonuclease H (rnhA)	0.0957	0.2647	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.1039	0.2874	0.2728
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0081	0.02	0.02
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0015	0.0056
Trypanosoma brucei	ingi protein (ORF1)	0.1039	0.2874	0.2728
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.007	0.0264
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0081	0.02	0.0755
Echinococcus granulosus	nAChR subunit	0.0015	0.0015	0.0056
Schistosoma mansoni	hypothetical protein	0.0081	0.02	0.02
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.5
Brugia malayi	Pre-SET motif family protein	0.0201	0.0534	0.2019
Brugia malayi	hypothetical protein	0.0228	0.0611	0.2308
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0015	0.0056
Trypanosoma brucei	ingi protein (ORF1)	0.1039	0.2874	0.2728
Echinococcus multilocularis	nAChR subunit	0.0015	0.0015	0.0056
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0015	0.0056
Brugia malayi	Cation transporter family protein	0.0015	0.0015	0.0056
Onchocerca volvulus		0.0229	0.0612	0.2312
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Brugia malayi	hypothetical protein	0.0081	0.02	0.0755
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0015	0.0015
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0015	0.0056
Toxoplasma gondii	ribonuclease HI protein	0.0957	0.2647	1
Brugia malayi	RNase H family protein	0.0957	0.2647	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0015	0.0208
Brugia malayi	reverse transcriptase	0.0081	0.02	0.0755
Loa Loa (eye worm)	glutaminase 2	0.0264	0.071	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0015	0.0056
Echinococcus granulosus	KRAB A domain containing protein	0.0081	0.02	0.0755
Trichomonas vaginalis	ribonuclease H1, putative	0.0957	0.2647	1
Onchocerca volvulus		0.0029	0.0053	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0081	0.02	0.0755
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.2161	0.8163
Onchocerca volvulus		0.0047	0.0103	0.0389
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0015	0.0056
Onchocerca volvulus		0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Giardia lamblia	Ribonuclease H	0.0957	0.2647	1
Brugia malayi	glutaminase DH11.1	0.0264	0.071	0.2684
Leishmania major	ribonuclease H1, putative	0.0957	0.2647	1
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.5
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0015	0.0056
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0015	0.0056
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Plasmodium vivax	SET domain protein, putative	0.0029	0.0053	0.5
Onchocerca volvulus		0.0081	0.02	0.0755
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Trypanosoma brucei	RNA helicase, putative	0.359	1	1
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0611	0.8599
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0015	0.0056
Schistosoma mansoni	hypothetical protein	0.0081	0.02	0.02
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0081	0.02	0.0755
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0015	0.0015
Onchocerca volvulus	Ribonuclease H1 homolog	0.0957	0.2647	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.5
Trichomonas vaginalis	glutaminase, putative	0.0264	0.071	0.2086
Schistosoma mansoni	protein kinase	0.0081	0.02	0.02
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Mycobacterium ulcerans	glutaminase	0.0264	0.071	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0053
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0081	0.02	0.0755
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0053	0.0201
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Echinococcus granulosus	RNA directed DNA polymerase	0.0081	0.02	0.0755
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0015	0.0056
Loa Loa (eye worm)	glutaminase	0.0264	0.071	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0015	0.0015
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.0611	0.2308
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Onchocerca volvulus		0.0015	0.0015	0.0056
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0081	0.02	0.0755
Schistosoma mansoni	phosphoglucomutase	0.0957	0.2647	0.2647
Brugia malayi	Cation transporter family protein	0.0015	0.0015	0.0056
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0015	0.0056
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Onchocerca volvulus		0.0015	0.0015	0.0056
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0015	0.0208
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0957	0.2647	0.5
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0081	0.02	0.0755
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0015	0.0208
Schistosoma mansoni	phosphoglucomutase	0.0957	0.2647	0.2647
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.02	0.02
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0015	0.0056
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0015	0.0056
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.005	0.019
Trypanosoma brucei	unspecified product	0.1039	0.2874	0.2728
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Echinococcus multilocularis	ribonuclease H1	0.0957	0.2647	1
Brugia malayi	Cation transporter family protein	0.0015	0.0015	0.0056
Brugia malayi	RNase H family protein	0.0957	0.2647	1
Onchocerca volvulus	Putative nachr subunit	0.0015	0.0015	0.0056
Schistosoma mansoni	nAChR subunit	0.0015	0.0015	0.0015
Brugia malayi	Pao retrotransposon peptidase family protein	0.0081	0.02	0.0755
Brugia malayi	Zinc knuckle family protein	0.0081	0.02	0.0755
Schistosoma mansoni	hypothetical protein	0.0035	0.007	0.007
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0015	0.0056
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0015	0.0056
Schistosoma mansoni	phosphoglucomutase	0.0957	0.2647	0.2647
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0053	0.0201
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0103	0.0103
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0015	0.0208
Onchocerca volvulus		0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0015	0.0056
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0015	0.0056
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0015	0.0056
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0053	0.0201
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0053	0.0053
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0142	0.0142
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0015	0.0056
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.007	0.007
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0053	0.075
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.0612	0.1684
Brugia malayi	Zinc knuckle family protein	0.0081	0.02	0.0755
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0015	0.0056
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0015	0.0015
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0015	0.0208
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0103	0.0389
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0015	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0015	0.0208
Trypanosoma cruzi	ribonuclease H1, putative	0.0957	0.2647	1
Onchocerca volvulus		0.0081	0.02	0.0755
Onchocerca volvulus		0.0015	0.0015	0.0056
Echinococcus multilocularis	RNA directed DNA polymerase	0.0081	0.02	0.0755
Brugia malayi	hypothetical protein	0.0081	0.02	0.0755
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0081	0.02	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.0611	0.2308
Echinococcus granulosus	ribonuclease H1	0.0957	0.2647	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0081	0.02	0.0755
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0053	0.0053
Mycobacterium tuberculosis	Possible maturase	0.0081	0.02	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0015	0.0056
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0015	0.0056
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0015	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0208
Trypanosoma cruzi	ribonuclease H1, putative	0.0957	0.2647	1
Schistosoma mansoni	glutaminase	0.0264	0.071	0.071
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0015	0.0056
Onchocerca volvulus		0.0015	0.0015	0.0056
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0142	0.0536
Trypanosoma brucei	ribonuclease H1	0.0957	0.2647	0.2497
Brugia malayi	reverse transcriptase	0.0081	0.02	0.0755
Schistosoma mansoni	hypothetical protein	0.0047	0.0103	0.0103
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0142	0.0142

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 100 %	Percent inhibition [3H]-Ro-15-1788 binding to Benzodiazepine receptor from bovine brain membrane at 10 uM	ChEMBL.	12477354
Inhibition (binding)	= 100 %	Percent inhibition [3H]-Ro-15-1788 binding to Benzodiazepine receptor from bovine brain membrane at 10 uM	ChEMBL.	12477354
Ki (binding)	= 44 nM	Binding affinity of the compound towards Benzodiazepine receptor from bovine brain membrane using [3H]-Ro-15-1788 as radioligand	ChEMBL.	12477354
Ki (binding)	= 44 nM	Binding affinity of the compound towards Benzodiazepine receptor from bovine brain membrane using [3H]-Ro-15-1788 as radioligand	ChEMBL.	12477354
Ratio (binding)	= 1.62	GABA ratio, relative binding in the presence and absence of 10 uM GABA (IC50-GABA/IC50+GABA)	ChEMBL.	12477354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11132021

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 264474