Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0009 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.517 | 0.6401 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0132 | 0.787 | 0.787 |
Brugia malayi | leucyl aminopeptidase | 0.0009 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Brugia malayi | FXNA | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.7309 | 0.905 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.8076 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0086 | 0.4964 | 0.4964 |
Leishmania major | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0009 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0012 | 0.0206 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0012 | 0.0206 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 uM | Agonist activity towards vanilloid receptor was tested in [Ca2+] influx assay by using neonatal rat culture spinal sensory neurons (NE=Not effective at 30 uM) | ChEMBL. | 12639539 |
IC50 (functional) | 0 uM | Antagonistic activity against vanilloid receptor, reduced capsaicin-induced [Ca2+] influx in neonatal rat spinal sensory neuronal cultures (ineffective at 30 uM) | ChEMBL. | 12639539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.