Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hexokinase | 0.0152 | 0.3828 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0562 | 0.0562 |
Entamoeba histolytica | hexokinase 2 | 0.0152 | 0.3828 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Echinococcus multilocularis | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Echinococcus granulosus | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Leishmania major | carbonic anhydrase-like protein | 0.0243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.336 | 0.336 |
Plasmodium vivax | hexokinase, putative | 0.0152 | 0.3828 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0243 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0145 | 0.336 | 0.336 |
Loa Loa (eye worm) | hexokinase | 0.0152 | 0.3828 | 0.3828 |
Onchocerca volvulus | 0.0152 | 0.3828 | 1 | |
Echinococcus granulosus | carbonic anhydrase II | 0.0243 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0152 | 0.3828 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0243 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0243 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0152 | 0.3828 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.336 | 0.336 |
Echinococcus granulosus | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Onchocerca volvulus | 0.0152 | 0.3828 | 1 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.0243 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0145 | 0.336 | 0.336 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0145 | 0.336 | 0.336 |
Echinococcus granulosus | hexokinase type 2 | 0.0152 | 0.3828 | 0.0706 |
Loa Loa (eye worm) | hexokinase | 0.0152 | 0.3828 | 0.3828 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0145 | 0.336 | 0.336 |
Schistosoma mansoni | hexokinase | 0.0152 | 0.3828 | 0.0706 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.336 | 0.336 |
Toxoplasma gondii | hexokinase | 0.0152 | 0.3828 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0145 | 0.336 | 0.336 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0243 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0243 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0152 | 0.3828 | 0.3828 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0145 | 0.336 | 0.336 |
Onchocerca volvulus | 0.0152 | 0.3828 | 1 | |
Echinococcus multilocularis | hexokinase type 2 | 0.0152 | 0.3828 | 0.0706 |
Loa Loa (eye worm) | hexokinase type II | 0.0152 | 0.3828 | 0.3828 |
Brugia malayi | hexokinase | 0.0152 | 0.3828 | 0.3828 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0243 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1400 nM | Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1 | ChEMBL. | 8496939 |
IC50 (binding) | = 1400 nM | Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1 | ChEMBL. | 8496939 |
IC50 (binding) | = 1400 nM | Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.