Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0783 | 0.1339 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0275 | 0.2791 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0872 | 0.1491 |
Schistosoma mansoni | ryanodine receptor related | 0.0764 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.1507 | 0.1483 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 0.8589 | 0.8585 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0275 | 0.2791 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0187 | 0.149 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0618 | 0.7855 | 0.9102 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0618 | 0.7855 | 0.9102 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.041 | 0.0701 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0233 | 0.2173 | 0.2151 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0668 | 0.8589 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 0.8589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.041 | 0.0701 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.041 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.5847 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0093 | 0.01 | 0.0072 |
Loa Loa (eye worm) | ryanodine receptor | 0.0285 | 0.2938 | 0.5025 |
Echinococcus multilocularis | expressed protein | 0.0361 | 0.4061 | 0.4464 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.01 | 0.017 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0482 | 0.5847 | 0.6647 |
Brugia malayi | cation channel family protein | 0.0326 | 0.3546 | 0.327 |
Loa Loa (eye worm) | ryanodine receptor | 0.018 | 0.1387 | 0.2372 |
Echinococcus granulosus | expressed protein | 0.0361 | 0.4061 | 0.4464 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.041 | 0.0383 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0482 | 0.5847 | 0.6647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.