Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0177 | 0.0264 | 0.0695 | |
Loa Loa (eye worm) | DPY-31 protein | 0.0177 | 0.0264 | 0.0011 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0353 | 0.1625 | 0.6037 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1436 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0269 | 0.0974 | 0.0739 |
Echinococcus multilocularis | Tolloid protein 1 | 0.1436 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0269 | 0.0974 | 0.3433 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0435 | 0.2262 | 0.8584 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1105 | 0.0874 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0177 | 0.0264 | 0.0597 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0248 | 0.0814 | 0.2793 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0404 | 0.202 | 0.1588 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.2262 | 0.2061 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0248 | 0.0814 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.2262 | 0.2061 |
Loa Loa (eye worm) | AStacin protease | 0.0881 | 0.571 | 0.5599 |
Brugia malayi | Trypsin family protein | 0.0286 | 0.1105 | 0.3958 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0248 | 0.0814 | 0.0316 |
Loa Loa (eye worm) | matrixin family protein | 0.0246 | 0.0802 | 0.0563 |
Schistosoma mansoni | egf-like domain protein | 0.0435 | 0.2262 | 0.2262 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.2617 | 0.2425 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0248 | 0.0814 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1105 | 0.0874 |
Onchocerca volvulus | Arrow homolog | 0.0435 | 0.2262 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0209 | 0.0514 | 0.0514 |
Echinococcus granulosus | laminin | 0.0481 | 0.2617 | 0.2217 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0481 | 0.2617 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0481 | 0.2617 | 0.2425 |
Onchocerca volvulus | Putative cubilin | 0.0175 | 0.0253 | 0.0645 |
Echinococcus multilocularis | laminin | 0.0481 | 0.2617 | 0.2217 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0177 | 0.0264 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.0887 | 0.065 |
Echinococcus multilocularis | integrin alpha 3 | 0.0358 | 0.1662 | 0.121 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0177 | 0.0264 | 0.0011 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0481 | 0.2617 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1436 | 1 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0719 | 0.4457 | 0.4313 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.0115 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.1379 | 0.9557 | 0.9545 |
Onchocerca volvulus | 0.0286 | 0.1105 | 0.4611 | |
Brugia malayi | Fibulin-1 precursor | 0.0481 | 0.2617 | 1 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0177 | 0.0264 | 0.0597 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0246 | 0.0802 | 0.32 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0286 | 0.1105 | 0.1105 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0175 | 0.0253 | 0.0554 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0467 | 0.2504 | 0.9549 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1625 | 0.1408 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0264 | 0.0011 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0405 | 0.2029 | 0.2029 |
Loa Loa (eye worm) | hypothetical protein | 0.0601 | 0.3541 | 0.3373 |
Echinococcus multilocularis | fibrillin 1 | 0.0481 | 0.2617 | 0.2217 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0404 | 0.202 | 0.1588 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0177 | 0.0264 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.1729 | 0.1514 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0481 | 0.2617 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0248 | 0.0814 | 0.0316 |
Schistosoma mansoni | integrin alpha | 0.0467 | 0.2504 | 0.2504 |
Brugia malayi | astacin protease protein 30 | 0.0177 | 0.0264 | 0.0597 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0435 | 0.2262 | 0.2061 |
Onchocerca volvulus | 0.0262 | 0.0926 | 0.3776 | |
Echinococcus granulosus | integrin alpha 3 | 0.0358 | 0.1662 | 0.121 |
Onchocerca volvulus | Matrilysin homolog | 0.0246 | 0.0802 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 25 mg kg-1 | Analgesic activity of intraperitoneally administered compound was determined by the inflamed rat-paw reversal of abnormal (three-legged) gait | ChEMBL. | 6325691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.