Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 alpha | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.5086 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.0116 | 0.5086 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.5086 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0116 | 0.5086 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0.5086 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0116 | 0.5086 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0.5086 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.5086 | 0.5086 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0116 | 0.5086 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0.5086 | 0.5086 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0.5086 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0116 | 0.5086 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0116 | 0.5086 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0.5086 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0.5086 | 0.5 |
Brugia malayi | intracellular kinase | 0.0116 | 0.5086 | 0.5086 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0.5086 | 0.5 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0116 | 0.5086 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0116 | 0.5086 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0.5086 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.5086 | 0.5086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 850 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 850 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 1590 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 1590 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 4.65 uM | Effective concentration in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
IC50 (binding) | > 5 uM | Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha | ChEMBL. | 11266159 |
IC50 (binding) | > 5 uM | Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha | ChEMBL. | 11266159 |
RE (binding) | = 0.3 | Relative efficacy in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.5 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.6 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.