Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0066 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0109 | 0.0739 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0223 | 0.1514 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0066 | 0.0144 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0294 | 0.0407 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0421 | 0.2631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0066 | 0.0446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0294 | 0.0644 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0294 | 0.0407 |
Onchocerca volvulus | 0.0055 | 0.0221 | 0.0221 | |
Echinococcus granulosus | tumor protein p63 | 0.0373 | 0.2312 | 0.5056 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0294 | 0.0644 |
Onchocerca volvulus | 0.0246 | 0.1479 | 0.1479 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0058 | 0.0127 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0055 | 0.0221 | 0.0482 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0066 | 0.0144 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0066 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1476 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0421 | 0.2631 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0294 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0221 | 0.1494 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0066 | 0.0144 |
Echinococcus multilocularis | tumor protein p63 | 0.0373 | 0.2312 | 0.5056 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0223 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0191 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0034 | 0.0231 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.1283 | 0.1774 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0294 | 0.0644 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0421 | 0.2631 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0294 | 0.1995 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0109 | 0.0239 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0294 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0223 | 0.1514 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0421 | 0.2631 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0066 | 0.0122 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0294 | 0.1995 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0294 | 0.0644 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0066 | 0.0144 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.1476 | 0.3228 |
Onchocerca volvulus | 0.0031 | 0.0066 | 0.0066 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0109 | 0.0151 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0066 | 0.0144 |
Brugia malayi | hypothetical protein | 0.0245 | 0.1476 | 0.2041 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0191 | 0.0418 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0191 | 0.0264 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.1476 | 0.3228 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0421 | 0.2631 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0294 | 0.1995 |
Onchocerca volvulus | 0.005 | 0.0191 | 0.0191 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0223 | 0.0309 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0066 | 0.0122 |
Giardia lamblia | Telomerase catalytic subunit | 0.0421 | 0.2631 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0716 | 0.4572 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0716 | 0.4572 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0421 | 0.2631 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0421 | 0.2631 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0294 | 0.0644 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0716 | 0.4572 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0066 | 0.0091 |
Brugia malayi | Telomerase reverse transcriptase | 0.1121 | 0.7231 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0034 | 0.0047 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.1283 | 0.8689 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0294 | 0.0644 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.1479 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (functional) | = 8.44 | Antagonistic activity against (5-hydroxytryptamine 2 receptor) serotonin-induced contractions in the rat jugular vein | ChEMBL. | 2299630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.